Eric Sibley, M.D., Ph.D.

Publications

• Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice. Chen C, Sibley E. Am J Physiol Gastrointest Liver Physiol. 2012; 302 (4): G407-19
• Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice. Chen C, Leavitt T, Sibley E. Biochem Biophys Res Commun. 2012; 424 (3): 549-53
• PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. Chen C, Fang R, Chou LC, Lowe AW, Sibley E. Biochem Biophys Res Commun. 2012; 423 (1): 183-7
• The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression. Fang L, Ahn JK, Wodziak D, Sibley E. Hum Genet. 2012; 131 (7): 1153-9
• 13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1. Olds LC, Ahn JK, Sibley E. Hum Genet. 2011; 129 (1): 111-3
• The Western transition. Sibley E, J Pediatr Gastroenterol Nutr. 2011; 52 (1): 2
• Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture. Sibley E, Ahn JK. Trans Am Clin Climatol Assoc. 2011: 122 155-65
• Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. Fu YY, Lu CH, Lin CW, Juang JH, Enikolopov G, Sibley E, Chiang AS, Tang SC. J Biomed Opt. 2010 Jul-Aug; 15 (4): 046018
• Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. Huang JJ, Joh JW, Fuentebella J, Patel A, Nguyen T, Seki S, Hoyte L, Reshamwala N, Nguyen C, Quiros A, Bass D, Sibley E, Berquist W, Cox K, Kerner J, Nadeau KC. Allergy Asthma Clin Immunol. 2010; 6 (1): 25
• Increased HLA-DR expression on tissue eosinophils in eosinophilic esophagitis. Patel AJ, Fuentebella J, Gernez Y, Nguyen T, Bass D, Berquist W, Cox K, Sibley E, Kerner J, Nadeau K. J Pediatr Gastroenterol Nutr. 2010; 51 (3): 290-4
• Ciao and Shalom. Sibley E, J Pediatr Gastroenterol Nutr. 2009
• Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution. Fu YY, Lin CW, Enikolopov G, Sibley E, Chiang AS, Tang SC. Gastroenterology. 2009; 137 (2): 453-65
• Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells. Chen C, Fang R, Davis C, Maravelias C, Sibley E. Am J Physiol Gastrointest Liver Physiol. 2009; 297 (6): G1126-37
• Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. Chen CA, Lo CK, Lin BL, Sibley E, Tang SC. Cancer Biol Ther. 2008; 7 (2): 303-9
• Transient cytochalasin-D treatment induces apically administered rAAV2 across tight junctions for transduction of enterocytes. Fu YY, Sibley E, Tang SC. J Gen Virol. 2008; 89 (Pt 12): 3004-8
• Genetic modification of somatic gut mucosa: an adeno-associated virus approach. Tang SC, Sibley E. J Pediatr Gastroenterol Nutr. 2006; 43 (2): 158-9
• Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice. Wang Z, Maravelias C, Sibley E. DNA Cell Biol. 2006; 25 (4): 215-22
• Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development. Fang R, Olds LC, Sibley E. Gene Expr Patterns. 2006; 6 (4): 426-32
• Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells. Tang SC, Sambanis A, Sibley E. Biochem Biophys Res Commun. 2005; 331 (4): 1392-400
• Carbohydrate intolerance. Sibley E, Curr Opin Gastroenterol. 2004; 20 (2): 162-7
• Genetic variation and lactose intolerance: detection methods and clinical implications. Sibley E, Am J Pharmacogenomics. 2004; 4 (4): 239-45
• PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene. Chao CK, Sibley E. Genet Test. 2004; 8 (2): 190-3
• Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. Wang Z, Fang R, Olds LC, Sibley E. Am J Physiol Gastrointest Liver Physiol. 2004; 287 (3): G555-61
• Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Olds LC, Sibley E. Hum Mol Genet. 2003; 12 (18): 2333-40
• Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. Lee SY, Madan A, Furuta GT, Colgan SP, Sibley E. Mol Genet Metab. 2002; 75 (1): 65-9
• Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. Lee SY, Wang Z, Lin CK, Contag CH, Olds LC, Cooper AD, Sibley E. J Biol Chem. 2002; 277 (15): 13099-105
• Subarachnoid hemorrhage and isolated atresia of the aortic arch. Sibley E, Doroshow RW, Milliken JC, Anand SK. J Emerg Med. 2002; 22 (2): 179-83
• Thyroid hormone and the d-type cyclins interact in regulating enterocyte gene transcription. Meng S, Badrinarain J, Sibley E, Fang R, Hodin R. J Gastrointest Surg. 2001 Jan-Feb; 5 (1): 49-55
• GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Fang R, Olds LC, Santiago NA, Sibley E. Am J Physiol Gastrointest Liver Physiol. 2001; 280 (1): G58-67
• The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Fang R, Santiago NA, Olds LC, Sibley E. Gastroenterology. 2000; 118 (1): 115-27
• Evolving asymmetric hypertrophic pyloric stenosis associated with histologic evidence of eosinophilic gastroenteritis. Blankenberg FG, Parker BR, Sibley E, Kerner JA. Pediatr Radiol. 1995; 25 (4): 310-1
• Characterization of the mouse insulin receptor gene promoter. Sibley E, Kastelic T, Kelly TJ, Lane MD. Proc Natl Acad Sci U S A. 1989; 86 (24): 9732-6
• Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit. Flores-Riveros JR, Sibley E, Kastelic T, Lane MD. J Biol Chem. 1989; 264 (36): 21557-72
• Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. Ntambi JM, Buhrow SA, Kaestner KH, Christy RJ, Sibley E, Kelly TJ, Lane MD. J Biol Chem. 1988; 263 (33): 17291-300
• Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. Cook JS, Lucas JJ, Sibley E, Bolanowski MA, Christy RJ, Kelly TJ, Lane MD. Proc Natl Acad Sci U S A. 1988; 85 (9): 2949-53
• High-level expression of a cloned HLA heavy chain gene introduced into mouse cells on a bovine papillomavirus vector. DiMaio D, Corbin V, Sibley E, Maniatis T. Mol Cell Biol. 1984; 4 (2): 340-50