{"result":[{"lastName":"Das","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biochemistry"}],"primaryAppointment":"Assistant Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10421&type=small&showNoImage","displayName":"Rhiju Das","firstName":"Rhiju","href":"http://med.stanford.edu/profiles/Rhiju_Das","researchInterest":"Rhiju Das strives to predict how sequence codes for structure in proteins, nucleic acids, and heteropolymers whose folds have yet to be explored. The Das group uses new computational and experimental tools to tackle the de novo modeling of protein and RNA folds, the high-throughput structure mapping of riboswitches and random RNAs, and the design of self-knotting and self-crystallizing nucleic acids."},{"lastName":"Garcia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4370&type=small&showNoImage","displayName":"Chris Garcia","firstName":"Chris","href":"http://med.stanford.edu/profiles/Chris_Garcia","researchInterest":"Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology.  We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches."},{"lastName":"Levitt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","displayName":"Michael Levitt","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Levitt","researchInterest":"Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling."},{"lastName":"Cooke","clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiology (Heart), Preventive"},{"focus":"Cardiovascular Disease"},{"focus":"Vascular Medicine"}],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4115&type=small&showNoImage","displayName":"John Cooke, MD, PhD","firstName":"John","href":"http://med.stanford.edu/profiles/John_Cooke","researchInterest":"Our translational research program involves molecular, cellular, animal and human studies of endothelial biology. We are focused on the role of nitric oxide synthase (NOS) in atherosclerosis and angiogenesis.  A new focus of investigation has resulted from our discovery of a novel angiogenic pathway mediated by endothelial nicotinic cholinergic receptors (nAChR). We use a wide variety of tools and approaches to investigate the role of NOS and nAChR pathways in cardiovascular biology and disease."},{"lastName":"Weis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","displayName":"William Weis","firstName":"William","href":"http://med.stanford.edu/profiles/William_Weis","researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion."},{"lastName":"Harbury","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4433&type=small&showNoImage","displayName":"Pehr Harbury","firstName":"Pehr","href":"http://med.stanford.edu/profiles/Pehr_Harbury","researchInterest":"Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides."},{"lastName":"Solomon","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8081&type=small&showNoImage","displayName":"Edward Solomon","firstName":"Edward","href":"http://med.stanford.edu/profiles/Edward_Solomon","researchInterest":""},{"lastName":"McKay","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","displayName":"David B. McKay","firstName":"David","href":"http://med.stanford.edu/profiles/David_McKay","researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules."},{"lastName":"Kaiser","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10008&type=small&showNoImage","displayName":"Stephen Kaiser","firstName":"Stephen","href":"http://med.stanford.edu/profiles/Stephen_Kaiser","researchInterest":""},{"lastName":"Jardetzky","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4190&type=small&showNoImage","displayName":"Oleg Jardetzky","firstName":"Oleg","href":"http://med.stanford.edu/profiles/Oleg_Jardetzky","researchInterest":"Structure, dynamics and function of proteins involved in transport and regulatory processes; high resolution nuclear magnetic resonance studies of conformational transitions and protein folding; study of the mechanism of action of the trp-repressor, ankyrin-domain proteins and the development of programs to calculate protein solution structure"},{"lastName":"Wender","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemistry"},{"appointment":"Professor (By courtesy),Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Chemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6111&type=small&showNoImage","displayName":"Paul Wender","firstName":"Paul","href":"http://med.stanford.edu/profiles/Paul_Wender","researchInterest":""},{"lastName":"Tsao","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Medicine - Cardiovascular Medicine"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4070&type=small&showNoImage","displayName":"Philip S. Tsao, PhD","firstName":"Philip","href":"http://med.stanford.edu/profiles/Philip_Tsao","researchInterest":""},{"lastName":"Baldwin","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6816&type=small&showNoImage","displayName":"Robert Baldwin","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Baldwin","researchInterest":"I closed my laboratory when I retired in 1998.  I continue to do research, chiefly in collaboration with Franc Avbelj, on problems of protein folding energetics, especially peptide backbone solvation,  and to write reviews."},{"lastName":"Alhamadsheh","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"primaryAppointment":"Postdoctoral Research fellow, Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10033&type=small&showNoImage","displayName":"Mamoun Alhamadsheh","firstName":"Mamoun","href":"http://med.stanford.edu/profiles/Mamoun_Alhamadsheh","researchInterest":""},{"lastName":"LI","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9800&type=small&showNoImage","displayName":"QING LI","firstName":"QING","href":"http://med.stanford.edu/profiles/QING_LI","researchInterest":"In embryonic/neonatal life, there is a wave of developmentally programmed islet cell death (apoptosis) in the pancreas in mice, rats, and humans.  Using gene chips, we have found that the gene expression of a number of genes activated by type 1 interferon (interferon alpha) increases sharply between postnatal weeks 3 and 4.  This is coincident with the time when large amounts of cellular breakdown products are released in the islets of Langerhans by a wave of developmentally programmed cell dea"},{"lastName":"Bertaccini","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor - Med Center Line,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4079&type=small&showNoImage","displayName":"Edward Bertaccini","firstName":"Edward","href":"http://med.stanford.edu/profiles/Edward_Bertaccini","researchInterest":"molecular modeling of anesthetic-protein interactions, molecular modeling of the ligand-gated ion channels"},{"lastName":"Puglisi","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4431&type=small&showNoImage","displayName":"Joseph (Jody) Puglisi","firstName":"Joseph","href":"http://med.stanford.edu/profiles/Joseph_Puglisi","researchInterest":"The Puglisi group investigates the role of RNA in cellular processes and disease.  We investigate dynamics using single-molecule approaches.  Our goal is a unified picture of structure, dynamics and function.  We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections.  A long-term goal is to target processes involving RNA with novel therapeutic strategies."},{"lastName":"Jadzinsky","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9775&type=small&showNoImage","displayName":"Pablo Jadzinsky","firstName":"Pablo","href":"http://med.stanford.edu/profiles/Pablo_Jadzinsky","researchInterest":""},{"lastName":"Kasson","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Chemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9965&type=small&showNoImage","displayName":"Peter Kasson","firstName":"Peter","href":"http://med.stanford.edu/profiles/Peter_Kasson","researchInterest":""},{"lastName":"Schnieders","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Chemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9408&type=small&showNoImage","displayName":"Michael J. Schnieders","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Schnieders","researchInterest":"My research interest is focused on deriving, implementing and applying new computational methods to problems in molecular biophysics. Contributions include:\r\n\r\n *  Polarizable multipole force field based refinement of X-Ray diffraction data.\r\n\r\n *  Analytic Generalized Kirkwood (GK) continuum electrostatics.\r\n\r\n *  Numerical polarizable multipole Poisson-Boltzmann (PMPB) continuum electrostatics."},{"lastName":"Qvit","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8817&type=small&showNoImage","displayName":"Nir Qvit","firstName":"Nir","href":"http://med.stanford.edu/profiles/Nir_Qvit","researchInterest":""},{"lastName":"Liu","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10051&type=small&showNoImage","displayName":"Fengling Liu","firstName":"Fengling","href":"http://med.stanford.edu/profiles/Fengling_Liu","researchInterest":""},{"lastName":"Boxer","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8050&type=small&showNoImage","displayName":"Steven Boxer","firstName":"Steven","href":"http://med.stanford.edu/profiles/Steven_Boxer","researchInterest":""},{"lastName":"Riley","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9852&type=small&showNoImage","displayName":"Brigit Erin RILEY","firstName":"Brigit","href":"http://med.stanford.edu/profiles/Brigit_Riley","researchInterest":""},{"lastName":"Puglisi","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Structural Biology"}],"primaryAppointment":"Assistant Professor (Research),Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10456&type=small&showNoImage","displayName":"Elisabetta Viani Puglisi","firstName":"Elisabetta","href":"http://med.stanford.edu/profiles/Elisabetta_Puglisi","researchInterest":"Viral infections and subsequent host response depend on multiple RNA-protein interaction. My research focuses on the structural and functional characterization of RNA-protein complexes involved in viral infection. Current research aims to understand how the Human Immunodeficiency Virus (HIV) initiates its replication upon host infection. We use NMR spectroscopy and x-ray crystallography to study the structure of the initiation complex, formed by a host tRNA and HIV genomic RNA, coupled with bio"}]}