{"result":[{"lastName":"de Jesus Perez","clinicalFocus":[{"focus":"Pulmonary Disease"},{"focus":"Pulmonary Hypertension"}],"appointments":[{"appointment":"Instructor,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Instructor,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7827&type=small&showNoImage","displayName":"Vinicio de Jesus Perez MD","firstName":"Vinicio","href":"http://med.stanford.edu/profiles/Vinicio_de Jesus Perez","researchInterest":"My work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH).   I am interested in understanding the role that the BMP  and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease."},{"lastName":"Alvira","clinicalFocus":[{"focus":"Intensive Care, Pediatric"},{"focus":"Pediatric Critical Care Medicine"}],"appointments":[{"appointment":"Instructor,Pediatrics - Intensive Care"}],"primaryAppointment":"Instructor,Pediatrics - Intensive Care","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6787&type=small&showNoImage","displayName":"Cristina M. Alvira","firstName":"Cristina","href":"http://med.stanford.edu/profiles/Cristina_Alvira","researchInterest":""},{"lastName":"Rabinovitch","clinicalFocus":[{"focus":"Cardiology (Heart), Pediatric"},{"focus":"Pediatric Cardiology"}],"appointments":[{"appointment":"Professor,Pediatrics - Cardiology"},{"appointment":"Professor (By courtesy),Developmental Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3897&type=small&showNoImage","displayName":"Marlene Rabinovitch","firstName":"Marlene","href":"http://med.stanford.edu/profiles/Marlene_Rabinovitch","researchInterest":"Our research focuses on understanding the regulation of genes associated with cardiovascular development and disease, through the use of cultured cells and tissues and genetically modified mouse models.   A variety of different aberrant pathways are being characterized, including those related to signaling through the bone morphogenetic proteins, serotonin and the S100 family of calcium binding proteins, and those defining how a microtubule associated protein regulates mRNA translation."},{"lastName":"Spiekerkoetter","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Instructor,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14775&type=small&showNoImage","displayName":"Edda Spiekerkoetter","firstName":"Edda","href":"http://med.stanford.edu/profiles/Edda_Spiekerkoetter","researchInterest":""},{"lastName":"Basina","clinicalFocus":[{"focus":"Endocrinology"},{"focus":"Endocrinology and Metabolism"},{"focus":"Type 1 Diabetes Mellitus"},{"focus":"Type 2 Diabetes Mellitus"},{"focus":"Thyroid Diseases"}],"appointments":[{"appointment":"Clinical Assistant Professor,Medicine - Endocrinology/Gerontology/Metab"}],"primaryAppointment":"Clinical Assistant Professor,Medicine - Endocrinology/Gerontology/Metab","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8519&type=small&showNoImage","displayName":"Marina Basina","firstName":"Marina","href":"http://med.stanford.edu/profiles/Marina_Basina","researchInterest":"Type I and type II diabetes, insulin pump therapy, glucose sensor technology, insulin resistance, PCOS, thyroid disorders"},{"lastName":"Cornfield","clinicalFocus":[{"focus":"Pediatric Pulmonary"},{"focus":"Pulmonary Medicine/Cystic Fibrosis, Pediatric"}],"appointments":[{"appointment":"Professor,Pediatrics - Pulmonary Medicine"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pediatrics - Pulmonary Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7127&type=small&showNoImage","displayName":"David Cornfield","firstName":"David","href":"http://med.stanford.edu/profiles/David_Cornfield","researchInterest":""},{"lastName":"Agalliu","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9742&type=small&showNoImage","displayName":"Dritan Agalliu PhD","firstName":"Dritan","href":"http://med.stanford.edu/profiles/Dritan_Agalliu","researchInterest":"I am interested in understanding the signaling pathways that regulate the development of specialized tight junctions in brain endothelial cells responsible for forming the blood-brain barrier. The identification of these signals is important for elucidating the mechanisms that regulate the entry of distinct compounds or drugs into the Central Nervous System (CNS) and the etiology of pathological CNS conditions associated with blood-brain barrier breakdown."},{"lastName":"Maduke","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3812&type=small&showNoImage","displayName":"Merritt Maduke","firstName":"Merritt","href":"http://med.stanford.edu/profiles/Merritt_Maduke","researchInterest":"Molecular mechanisms of chloride channels & transporters studied by integration of structural and electrophysiological methods."},{"lastName":"van Amerongen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9613&type=small&showNoImage","displayName":"Renee van Amerongen","firstName":"Renee","href":"http://med.stanford.edu/profiles/Renee_van Amerongen","researchInterest":"Alternative modes of Wnt-signal transduction"},{"lastName":"Axelrod","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","displayName":"Jeffrey Axelrod","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization."},{"lastName":"Zamanian","clinicalFocus":[{"focus":"Pulmonary Hypertension"},{"focus":"Pulmonology (Lung) and Critical Care "},{"focus":"Pulmonary Medicine"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7572&type=small&showNoImage","displayName":"Roham Zamanian","firstName":"Roham","href":"http://med.stanford.edu/profiles/Roham_Zamanian","researchInterest":"1. The Utility of S100A4/Mts1 as a Biomarker in Pulmonary Arterial Hypertension (PAH).\r\n\r\n2. Prevalence and Treatment of Insulin Resistance in PAH.\r\n\r\n3. The Effect of EGF-Receptor Blockade and Elastase Inhibitor on Pulmonary Arteries of Patients with PAH.\r\n\r\n4. Characterization of Pulmonary Arteries in Patients with Idiopathic and Secondary PAH by Wedge Angiography.\r\n\r\n5. The Optimal Angle for Angiographic Evaluation of the Left Pulmonary Artery in Patients with PAH."},{"lastName":"Spin","clinicalFocus":[{"focus":"Aortic Disease"},{"focus":"Marfan Syndrome and Aortic Disorders"},{"focus":"Cardiovascular Disease"}],"appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6448&type=small&showNoImage","displayName":"Joshua M. Spin","firstName":"Joshua","href":"http://med.stanford.edu/profiles/Joshua_Spin","researchInterest":"Dr. Spin began his research career studying the structural biology of low density lipoprotein, and has been augmenting his skills with intensive training in molecular biology techniques, particularly those involving high-throughput genetic expression profiling. He is especially interested in vascular smooth muscle cells, and the role of smooth muscle differentiation and phenotypic switching in development and vascular disease."},{"lastName":"Pearl","clinicalFocus":[{"focus":"Anesthesia"},{"focus":"Critical Care Medicine"}],"appointments":[{"appointment":"Professor,Anesthesia"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4680&type=small&showNoImage","displayName":"Ronald Pearl","firstName":"Ronald","href":"http://med.stanford.edu/profiles/Ronald_Pearl","researchInterest":"Mechanims (molecular and cellular) of pulmonary hypertension, treatment of pulmonary hypertension, treatment of respiratory failure, treatment of septic shock, hemodynamic monitoring"},{"lastName":"Holgado-Madruga","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Neurosurgery"}],"primaryAppointment":"Instructor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7072&type=small&showNoImage","displayName":"Marina Holgado-Madruga","firstName":"Maria","href":"http://med.stanford.edu/profiles/Maria_Holgado-Madruga","researchInterest":""},{"lastName":"Park","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8769&type=small&showNoImage","displayName":"Hyokeun Park","firstName":"Hyokeun","href":"http://med.stanford.edu/profiles/Hyokeun_Park","researchInterest":""},{"lastName":"Kim","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, School of Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9340&type=small&showNoImage","displayName":"Yu-Mee Kim","firstName":"Yu-Mee","href":"http://med.stanford.edu/profiles/Yu-Mee_Kim","researchInterest":""},{"lastName":"Stankunas","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","displayName":"Kryn Stankunas","firstName":"Kryn","href":"http://med.stanford.edu/profiles/Kryn_Stankunas","researchInterest":""},{"lastName":"Feinstein","clinicalFocus":[{"focus":"Pediatric Cardiology"},{"focus":"Congenital Heart Defects"},{"focus":"Pulmonary Hypertension"},{"focus":"Pulmonary Vascular Disease"},{"focus":"Pulmonary Vascular Abnormalities"},{"focus":"Cardiac Catheterization"},{"focus":"Biomechanical Engineering / Bioengineering"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pediatrics - Cardiology"},{"appointment":"Associate Professor - Med Center Line (By courtesy),Bioengineering"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4396&type=small&showNoImage","displayName":"Jeffrey A. Feinstein, MD, MPH","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/Jeffrey_Feinstein","researchInterest":"Research interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) development and testing of transcatheter therapies for the treatment of congenital heart disease, and (3) the evaluation and treatment of pulmonary hypertension/pulmonary vascular disease."},{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration."},{"lastName":"Sivaramakrishnan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biochemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10127&type=small&showNoImage","displayName":"Sivaraj Sivaramakrishnan","firstName":"Sivaraj","href":"http://med.stanford.edu/profiles/Sivaraj_Sivaramakrishnan","researchInterest":""},{"lastName":"Tsao","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Medicine - Cardiovascular Medicine"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4070&type=small&showNoImage","displayName":"Philip S. Tsao, PhD","firstName":"Philip","href":"http://med.stanford.edu/profiles/Philip_Tsao","researchInterest":""},{"lastName":"Gurtner","clinicalFocus":[{"focus":"Plastic Surgery"}],"appointments":[{"appointment":"Professor - Med Center Line,Surgery - Plastic/Recon Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Surgery - Plastic/Recon Surgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6890&type=small&showNoImage","displayName":"Geoffrey Gurtner","firstName":"Geoffrey","href":"http://med.stanford.edu/profiles/Geoffrey_Gurtner","researchInterest":"Geoffrey Gurtner's Lab is interested in understanding the mecahnism of new blood vessel growth following injury and how pathways of tissue regeneration and fibrosis interact in wound healing."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Kao","clinicalFocus":[{"focus":"Pulmonary Disease"},{"focus":"Pulmonology (Lung) and Critical Care "}],"appointments":[{"appointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med"}],"primaryAppointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5961&type=small&showNoImage","displayName":"Peter Kao","firstName":"Peter","href":"http://med.stanford.edu/profiles/Peter_Kao","researchInterest":"Our research program has several active projects:\r\n1.) Pulmonary Vascular Disease \u0096 Simvastatin reversed experimental pulmonary hypertension, and is safe for treatment of patients. Blinded clinical trials of efficacy are in progress.\r\n2.) Lung inflammation and regeneration (stem cells)\r\n3.) Lung surfactant rheology and oxidative stress\r\n4.) Gene regulation by RNA binding proteins, NF45 and NF90 through transcriptional and posttranscriptional mechanisms"}]}