{"result":[{"lastName":"Lu","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","displayName":"Bingwei Lu","firstName":"Bingwei","href":"http://med.stanford.edu/profiles/Bingwei_Lu","researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions."},{"lastName":"Axelrod","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","displayName":"Jeffrey Axelrod","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization."},{"lastName":"Clandinin","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3885&type=small&showNoImage","displayName":"Thomas Clandinin","firstName":"Thomas","href":"http://med.stanford.edu/profiles/Thomas_Clandinin","researchInterest":"My lab addresses two distinct questions.  That is, how can precise patterns of neuronal connections be genetically programmed during development, and how, once formed, can such circuits be used to mediate complex visual behaviors?   Using the fruit fly visual system as a model, we employ genetic approaches to manipulate the functions of genes and neurons. From this, we infer specific developmental roles for particular molecules, and infer specific computational roles for individual neurons."},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration."},{"lastName":"Schneider","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Microbiology & Immunology"}],"primaryAppointment":"Associate Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4580&type=small&showNoImage","displayName":"David Schneider","firstName":"David","href":"http://med.stanford.edu/profiles/David_Schneider","researchInterest":"We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including:  Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, parasites and viruses."},{"lastName":"Scott","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","displayName":"Matthew Scott","firstName":"Matthew","href":"http://med.stanford.edu/profiles/Matthew_Scott","researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size."},{"lastName":"Krasnow","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","displayName":"Mark Krasnow","firstName":"Mark","href":"http://med.stanford.edu/profiles/Mark_Krasnow","researchInterest":"Genetic and molecular basis of respiratory system  development, maintenance, and disease in Drosophila, mouse, and human"},{"lastName":"Fuller","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4159&type=small&showNoImage","displayName":"Margaret T. Fuller","firstName":"Margaret","href":"http://med.stanford.edu/profiles/Margaret_Fuller","researchInterest":"Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis."},{"lastName":"Holgado-Madruga","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Neurosurgery"}],"primaryAppointment":"Instructor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7072&type=small&showNoImage","displayName":"Marina Holgado-Madruga","firstName":"Maria","href":"http://med.stanford.edu/profiles/Maria_Holgado-Madruga","researchInterest":""},{"lastName":"Baker","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","displayName":"Bruce Baker","firstName":"Bruce","href":"http://med.stanford.edu/profiles/Bruce_Baker","researchInterest":""},{"lastName":"Sen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Dermatology"}],"primaryAppointment":"Postdoctoral Research fellow, Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10169&type=small&showNoImage","displayName":"George Sen","firstName":"George","href":"http://med.stanford.edu/profiles/George_Sen","researchInterest":""},{"lastName":"Luo","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor (By courtesy),Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6229&type=small&showNoImage","displayName":"Liqun Luo","firstName":"Liqun","href":"http://med.stanford.edu/profiles/Liqun_Luo","researchInterest":"We are studying how neural circuits are assembled during development, and how they contribute to sensory perception.  We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior.  We are primarily using Drosophila as a model organism for our studies.  Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain."},{"lastName":"Rothenberg","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10397&type=small&showNoImage","displayName":"Michael Rothenberg","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Rothenberg","researchInterest":""},{"lastName":"Tran","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9649&type=small&showNoImage","displayName":"David Tran","firstName":"David","href":"http://med.stanford.edu/profiles/David_Tran","researchInterest":""},{"lastName":"Bronte-Stewart","clinicalFocus":[{"focus":"Neurology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Neurology & Neurological Sciences"},{"appointment":"Associate Professor - Med Center Line (By courtesy),Neurosurgery"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4377&type=small&showNoImage","displayName":"Helen Bronte-Stewart","firstName":"Helen","href":"http://med.stanford.edu/profiles/Helen_Bronte-Stewart","researchInterest":"My research focus is human motor control and brain pathophysiology in movement disorders.  Our overall goal is to understand the role of the basal ganglia electrical activity in the pathogenesis of movement disorders.  We have developed novel computerized technology to measure fine, limb and postural movement.  With these we are measuring local field potentials in basal ganglia nuclei in patients with Parkinson's disease and dystonian and correlating brain signalling with motor behavior."},{"lastName":"Olzmann","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9630&type=small&showNoImage","displayName":"James Olzmann","firstName":"James","href":"http://med.stanford.edu/profiles/James_Olzmann","researchInterest":""},{"lastName":"Tobin","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Sr Research Scholar (PI Waiver),Center for Biomedical Ethics"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6945&type=small&showNoImage","displayName":"Sara L. (Sally) Tobin","firstName":"Sara","href":"http://med.stanford.edu/profiles/Sara_Tobin","researchInterest":"Tobin is a Senior Research Scholar in the Program for Genomics, Ethics, and Society at the Stanford Center for Biomedical Ethics. She obtained her Ph.D. in Developmental Biology from the University of Washington and did postdoctoral research in Genetics at the University of California, Berkeley and in Biochemistry at the University of California, San Francisco. She became a faculty member at the University of Oklahoma College of Medicine in 1983, where she established her independent research l"},{"lastName":"Vogel","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"},{"appointment":"Professor - Med Center Line (By courtesy),Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3892&type=small&showNoImage","displayName":"Hannes Vogel","firstName":"Hannes","href":"http://med.stanford.edu/profiles/Hannes_Vogel","researchInterest":"My research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Chan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4423&type=small&showNoImage","displayName":"Pak H. Chan","firstName":"Pak","href":"http://med.stanford.edu/profiles/Pak_Chan","researchInterest":"Neuronal death after cerebral ischemia and neural injury using transgenic strategy"},{"lastName":"Kosek","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Pathology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4524&type=small&showNoImage","displayName":"Jon Kosek","firstName":"Jon","href":"http://med.stanford.edu/profiles/Jon_Kosek","researchInterest":"Methods of evaluation of biopsies; differentiation and, classification of neoplasms; immunohistochemistry; scanning and, transmission electron microscopy; cardiovascular pathology;, histologic assessment of bone biopsies; heart preservation and, restoration; myocardial biopsies; venous autograft coronary artery, bypass; cardial and heart valve transplantation."},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus (Active) Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Barreto","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Anesthesia"}],"primaryAppointment":"Postdoctoral Research fellow, Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=11191&type=small&showNoImage","displayName":"George Barreto","firstName":"George","href":"http://med.stanford.edu/profiles/George_Barreto","researchInterest":"My interests lie on the glia reactivity and proliferation with aging after focal ischemic injury. Some aims are proposed:\r\n* Role of astrocyte and microglia impairment in focal ischemia;\r\n\r\nand\r\n\r\n* Gene therapy for stroke with superoxide dismutase 2."}]}