{"result":[{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Chan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9968&type=small&showNoImage","displayName":"Denise Chan","firstName":"Denise","href":"http://med.stanford.edu/profiles/Denise_Chan","researchInterest":""},{"lastName":"Denko","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4577&type=small&showNoImage","displayName":"Nicholas Denko","firstName":"Nicholas","href":"http://med.stanford.edu/profiles/Nicholas_Denko","researchInterest":"We are interested in the biologic effect of gene expression changes that occur in the solid tumor.  Many of these expression changes are due to the micro-physiology within the tumor.  Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention.  We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes."},{"lastName":"Attardi","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3851&type=small&showNoImage","displayName":"Laura Attardi","firstName":"Laura","href":"http://med.stanford.edu/profiles/Laura_Attardi","researchInterest":"Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse."},{"lastName":"Razorenova","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9869&type=small&showNoImage","displayName":"Olga Razorenova","firstName":"Olga","href":"http://med.stanford.edu/profiles/Olga_Razorenova","researchInterest":""},{"lastName":"Ameri","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Surgery"}],"primaryAppointment":"Postdoctoral Research fellow, Surgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8979&type=small&showNoImage","displayName":"Kurosh Ameri","firstName":"Kurosh","href":"http://med.stanford.edu/profiles/Kurosh_Ameri","researchInterest":"My research interests include the influence of tumor microenvironment on generation of circulating tumor cells (CTCs), which circulate the body and metastasize to distant organs. Specific interests: 1. The role of tumor hypoxia and tumor anoxia in generation of CTCs; 2. The role of anoxia factors in determing resistance to anti-angiogensis therapy; 3. Exploiting anoxia pathways in cancer imaging and CTC imaging; 4. Exploiting anoxia induced nutritional pathways in cancer therapy and imaging."},{"lastName":"Leppert","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Urology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor - Med Center Line,Urology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10322&type=small&showNoImage","displayName":"John Leppert","firstName":"John","href":"http://med.stanford.edu/profiles/John_Leppert","researchInterest":"To improve the global quality of care for patients with kidney cancer. We are working to identify novel biomarkers to detect renal cell carcinoma and predict response to systemic therapy. Additionally, we are assembling large datasets of patients diagnosed with kidney cancer to improve patient staging and prognostic information. Finally, we are developing surgical technologies that are applicable to endoscopic, laparoscopic and robotic renal surgery."},{"lastName":"Harshman","clinicalFocus":[{"focus":"Oncology"},{"focus":"Genitourinary Cancer"}],"appointments":[{"appointment":"Acting Assistant Professor,Medicine - Oncology"}],"primaryAppointment":"Acting Assistant Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8928&type=small&showNoImage","displayName":"Lauren Harshman","firstName":"Lauren","href":"http://med.stanford.edu/profiles/Lauren_Harshman","researchInterest":""},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10527&type=small&showNoImage","displayName":"Dan Levy","firstName":"Dan","href":"http://med.stanford.edu/profiles/Dan_Levy","researchInterest":""},{"lastName":"Wong","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Instructor,Dermatology"},{"appointment":"Postdoctoral Research fellow, Dermatology"}],"primaryAppointment":"Instructor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7991&type=small&showNoImage","displayName":"David J. Wong, M.D., Ph.D.","firstName":"David","href":"http://med.stanford.edu/profiles/David_Wong","researchInterest":"My research interest is focused on investigating the molecular networks that underlie cancer stem cells and designing therapies that selectively target these cells, thereby eliminating a cancer's potential for regrowth."},{"lastName":"Choi","clinicalFocus":[{"focus":"Radiation Oncology"},{"focus":"Radiation Therapy"}],"appointments":[{"appointment":"Clinical Assistant Professor,Neurosurgery"}],"primaryAppointment":"Clinical Assistant Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8332&type=small&showNoImage","displayName":"Clara Y. Choi, M.D., Ph.D.","firstName":"Clara","href":"http://med.stanford.edu/profiles/Clara_Choi","researchInterest":""},{"lastName":"Pollack","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6066&type=small&showNoImage","displayName":"Jonathan Pollack","firstName":"Jonathan","href":"http://med.stanford.edu/profiles/Jonathan_Pollack","researchInterest":"Our laboratory uses genomics approaches to explore patterns of gene expression and gene copy number alteration in both human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies."},{"lastName":"Clarke","clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","displayName":"Michael F. Clarke, M.D.","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Clarke","researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa"},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to exploit tumor hypoxia with drugs activated by hypoxia and anaerobic bacteria as tumor-specific gene therapy vectors. We are also testing ways of inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Koong","clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Colorectal Cancer - Radiation Oncology"},{"focus":"Esophageal Cancer"},{"focus":"Esophageal Cancer - Radiation Oncology"},{"focus":"Liver Cancer"},{"focus":"Liver Cancer - Radiation Oncology"},{"focus":"Pancreatic Cancer "},{"focus":"Pancreatic Cancer - Radiation Oncology"},{"focus":"Radiation Oncology"},{"focus":"Rectal Cancer "},{"focus":"Rectal Cancer - Radiation Oncology"},{"focus":"Stomach Cancer "},{"focus":"Stomach Cancer - Radiation Oncology"}],"appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4729&type=small&showNoImage","displayName":"Albert Koong","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Koong","researchInterest":"The focus of my laboratory is to understand the role of hypoxia and the tumor microenvironment on malignant progression. My clinical area of interest is in the application of chemoradiotherapy and stereotactic radiosurgery for GI maligancies"},{"lastName":"Tibshirani","clinicalFocus":[],"appointments":[{"appointment":"Professor,Health Research & Policy - Biostatistics"},{"appointment":"Professor,Statistics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Health Research & Policy - Biostatistics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4688&type=small&showNoImage","displayName":"Robert Tibshirani","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Tibshirani","researchInterest":"My research is in applied statistics and biostatistics. I specialize in \u000bcomputer-intensive methods for regression and classification, bootstrap, cross-validation\u000band statistical inference, and signal and image analysis for medical diagnosis."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Srinivas","clinicalFocus":[{"focus":"Bladder Cancer"},{"focus":"Bladder Cancer - Medical Oncology"},{"focus":"Germ Cell Tumors"},{"focus":"Germ Cell Tumors - Medical Oncology"},{"focus":"Germ Cell Tumors - Urologic Oncology"},{"focus":"Kidney Cancer"},{"focus":"Kidney Cancer - Medical Oncology"},{"focus":"Male Cancers - Penile"},{"focus":"Male Cancers - Prostate "},{"focus":"Male Cancers - Testicular "},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"},{"focus":"Penile Cancer"},{"focus":"Prostate Cancer"},{"focus":"Prostate Cancer - Medical Oncology"},{"focus":"Testicular Tumors"},{"focus":"Testicular Tumors - Medical Oncology"},{"focus":"Ureteral Cancer"},{"focus":"Ureteral Cancer - Medical Oncology"},{"focus":"Urethral Cancer"},{"focus":"Urethral Cancer - Medical Oncology"},{"focus":"Urologic Cancers"},{"focus":"Urologic Cancers - Medical Oncology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Oncology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4350&type=small&showNoImage","displayName":"Sandhya Srinivas","firstName":"Sandhya","href":"http://med.stanford.edu/profiles/Sandhya_Srinivas","researchInterest":"Clinical interests: general oncology, genito-urinary malignancy Research interests: conducting clinical trials in advanced prostate cancer, bladder cancer and renal cell carcinoma"},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."},{"lastName":"Holgado-Madruga","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Neurosurgery"}],"primaryAppointment":"Instructor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7072&type=small&showNoImage","displayName":"Marina Holgado-Madruga","firstName":"Maria","href":"http://med.stanford.edu/profiles/Maria_Holgado-Madruga","researchInterest":""},{"lastName":"Noonan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10537&type=small&showNoImage","displayName":"Emily Noonan Ph.D.","firstName":"Emily","href":"http://med.stanford.edu/profiles/Emily_Noonan","researchInterest":"chemoprevetion, HDAC inhibitors, miRNAs, tumor suppressor genes"},{"lastName":"Dalerba","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Oncology"}],"primaryAppointment":"Instructor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9693&type=small&showNoImage","displayName":"Piero Dalerba","firstName":"Piero","href":"http://med.stanford.edu/profiles/Piero_Dalerba","researchInterest":"Cancer Stem Cells, Colon Cancer"},{"lastName":"Felsher","clinicalFocus":[{"focus":"Hodgkin's Disease"},{"focus":"Hodgkin's Disease - Hematology"},{"focus":"Hodgkin's Disease - Medical Oncology"},{"focus":"Lymphoma "},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5931&type=small&showNoImage","displayName":"Dean W. Felsher","firstName":"Dean","href":"http://med.stanford.edu/profiles/Dean_Felsher","researchInterest":"My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation."}]}