{"result":[{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Hanawalt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5957&type=small&showNoImage","displayName":"Philip Hanawalt","firstName":"Philip","href":"http://med.stanford.edu/profiles/Philip_Hanawalt","researchInterest":"Hanawalt has been a productive researcher in the field of DNA repair since his pioneering discovery of repair replication in E. coli in 1963. He also first demonstrated repair replication in mycoplasmata and in a eukaryote and he has developed a number of important experimental approaches for studying repair, beginning with the BrdUrd density labeling method for resolving semiconservatively replicated DNA from parental DNA containing repair patches. Hanawalt\u0092s approach was used to validate the "},{"lastName":"Wang","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4110&type=small&showNoImage","displayName":"Teresa Wang","firstName":"Teresa","href":"http://med.stanford.edu/profiles/Teresa_Wang","researchInterest":"The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication."},{"lastName":"Choi","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13431&type=small&showNoImage","displayName":"Jinkuk Choi","firstName":"Jinkuk","href":"http://med.stanford.edu/profiles/Jinkuk_Choi","researchInterest":""},{"lastName":"Goley","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9747&type=small&showNoImage","displayName":"Erin Goley","firstName":"Erin","href":"http://med.stanford.edu/profiles/Erin_Goley","researchInterest":""},{"lastName":"Burkholder","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6211&type=small&showNoImage","displayName":"Bill Burkholder","firstName":"Bill","href":"http://med.stanford.edu/profiles/Bill_Burkholder","researchInterest":"Our lab is interested in how bacteria monitor and coordinate cell cycle events. We are focused on identifying and characterizing signal transduction pathways used by the bacterium Bacillus subtilis to regulate cell cycle progression and development in response to chromosome status. Our goal is to understand how these pathways work mechanistically and how they contribute to normal growth, development, and genome stability."},{"lastName":"Cohen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","displayName":"Stanley N. Cohen, MD","firstName":"Stanley","href":"http://med.stanford.edu/profiles/Stanley_Cohen","researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis."},{"lastName":"Shang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, School of Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10197&type=small&showNoImage","displayName":"Ching Shang","firstName":"Ching","href":"http://med.stanford.edu/profiles/Ching_Shang","researchInterest":""},{"lastName":"Calos","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4100&type=small&showNoImage","displayName":"Michele Calos","firstName":"Michele","href":"http://med.stanford.edu/profiles/Michele_Calos","researchInterest":"My lab is developing novel vectors and strategies for gene and cell therapy.  We are focused on creating and using plasmid DNA vectors that integrate into the genome in a sequence-specific manner.  We are developing innovative gene and cell therapies for genetic diseases such as hemophilia and muscular dystrophy, including approaches involving stem cells."},{"lastName":"Artandi","clinicalFocus":[{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3848&type=small&showNoImage","displayName":"Steven Artandi","firstName":"Steven","href":"http://med.stanford.edu/profiles/Steven_Artandi","researchInterest":"Telomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging.  We are interested in how telomere shortening influences cancer, stem cell function and genomic stability.  Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer.  We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches."},{"lastName":"Chua","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6623&type=small&showNoImage","displayName":"Katrin Chua","firstName":"Katrin","href":"http://med.stanford.edu/profiles/Katrin_Chua","researchInterest":"Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals.  We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies.  In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress.  We have now begun to characterize the molecular mechanisms b"},{"lastName":"Yan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13412&type=small&showNoImage","displayName":"Kelley Yan","firstName":"Kelley","href":"http://med.stanford.edu/profiles/Kelley_Yan","researchInterest":""},{"lastName":"Seita","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Cancer/Stem Cell Biology Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Cancer/Stem Cell Biology Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10040&type=small&showNoImage","displayName":"Jun Seita","firstName":"Jun","href":"http://med.stanford.edu/profiles/Jun_Seita","researchInterest":""},{"lastName":"Tang","clinicalFocus":[{"focus":"Dermatology"},{"focus":"Skin Cancer"},{"focus":"Epidemiology"},{"focus":"Clinical Trial"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Dermatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor - Med Center Line,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10735&type=small&showNoImage","displayName":"Jean Y. Tang MD PhD","firstName":"Jean","href":"http://med.stanford.edu/profiles/Jean_Tang","researchInterest":"My research focuses on finding new ways to treat and prevent non-melanoma skin cancer. I am committed to bringing laboratory-based insights to benefit our patients. I am interested in these questions:\r\n1. How do we prevent skin cancer? \r\n2. What is the relationship between sunlight, vitamin D, and skin cancer risk? \r\n3. Can we target certain tumor signaling pathways (Hedgehog pathway) to treat basal cell carcinomas - the most common cancer in the US?"},{"lastName":"Ford","clinicalFocus":[{"focus":"Cancer Genetics"},{"focus":"Gastrointestinal Cancers - Genetics"},{"focus":"Gastrointestinal Cancers - Medical Oncology"},{"focus":"Breast Cancer - Genetics"},{"focus":"Ovarian Cancer - Genetics"},{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Associate Professor (By courtesy),Pediatrics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4066&type=small&showNoImage","displayName":"James Ford","firstName":"James","href":"http://med.stanford.edu/profiles/James_Ford","researchInterest":"Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNA\u000bdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to exploit tumor hypoxia with drugs activated by hypoxia and anaerobic bacteria as tumor-specific gene therapy vectors. We are also testing ways of inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Smith","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Radiation Oncology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7014&type=small&showNoImage","displayName":"Kendric C. Smith","firstName":"Kendric","href":"http://med.stanford.edu/profiles/Kendric_Smith","researchInterest":"The photochemistry and radiation chemistry of DNA, the genetic control and biochemical bases of the multiple pathways of DNA repair, and the roles of DNA repair processes in radiation and spontaneous mutagenesis. Over 190 papers have been published on these and related topics."},{"lastName":"Kalisky","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10137&type=small&showNoImage","displayName":"Tomer Kalisky","firstName":"Tomer","href":"http://med.stanford.edu/profiles/Tomer_Kalisky","researchInterest":"Single cell gene expression, cancer stem cells, biological networks, systems biology"},{"lastName":"Shapiro","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Senior Fellow (By courtesy),Spogli Inst for Intrntl Studies"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4316&type=small&showNoImage","displayName":"Lucy Shapiro","firstName":"Lucille","href":"http://med.stanford.edu/profiles/Lucille_Shapiro","researchInterest":"A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Pang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9916&type=small&showNoImage","displayName":"Phillip S. Pang","firstName":"Phillip","href":"http://med.stanford.edu/profiles/Phillip_Pang","researchInterest":"Translational bioinformatics and molecular virology of hepatitis C. \r\n\r\nMy work focuses on two broad areas: (a) using computational/statistical techniques, including phylogenomic analysis and monte carlo simulation, to study viral-host interactions; (b) using molecular virology techniques to study hepatitis C replication and pathogensis"},{"lastName":"Morrison","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","displayName":"Ashby Morrison","firstName":"Ashby","href":"http://med.stanford.edu/profiles/Ashby_Morrison","researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity."},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10527&type=small&showNoImage","displayName":"Dan Levy","firstName":"Dan","href":"http://med.stanford.edu/profiles/Dan_Levy","researchInterest":""},{"lastName":"Krieg","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9143&type=small&showNoImage","displayName":"Adam Krieg","firstName":"Adam","href":"http://med.stanford.edu/profiles/Adam_Krieg","researchInterest":""}]}