{"result":[{"lastName":"Jackson","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4463&type=small&showNoImage","displayName":"Peter Jackson","firstName":"Peter","href":"http://med.stanford.edu/profiles/Peter_Jackson","researchInterest":"Cell cycle and cyclin control of DNA replication ."},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines."},{"lastName":"Nachury","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","displayName":"Maxence Nachury","firstName":"Maxence","href":"http://med.stanford.edu/profiles/Maxence_Nachury","researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways."},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Stearns","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6244&type=small&showNoImage","displayName":"Tim Stearns","firstName":"Tim","href":"http://med.stanford.edu/profiles/Tim_Stearns","researchInterest":"We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?"},{"lastName":"Wakelee","clinicalFocus":[{"focus":"Investigational Therapeutics"},{"focus":"Lung Cancer - Medical Oncology"},{"focus":"Medical Oncology"},{"focus":"Mesothelioma "},{"focus":"Mesothelioma - Medical Oncology"},{"focus":"Oncology (Cancer)"},{"focus":"Thoracic Cancers"},{"focus":"Thoracic Cancers - Medical Oncology"},{"focus":"thymoma"},{"focus":"thymic carcinoma"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Oncology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6058&type=small&showNoImage","displayName":"Heather Wakelee","firstName":"Heather","href":"http://med.stanford.edu/profiles/Heather_Wakelee","researchInterest":"Dr. Wakelee's research is focused on clinical trials in lung cancer patients.  She also works with novel agents for all malignancies as part of the developmental therapeutics group of the cancer center."},{"lastName":"Mahjoub","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9545&type=small&showNoImage","displayName":"Mohamed Mahjoub","firstName":"Mohamed","href":"http://med.stanford.edu/profiles/Mohamed_Mahjoub","researchInterest":"Cilia are microtubule-based organelles that provide cells with diverse organization and motility functions. Defects in the assembly and function of cilia lead to a range of human diseases referred to as ciliopathies. The Stearns lab have analyzed the transcriptional profile of tracheal epithelial cells during ciliogenesis, and identified many up-regulated genes. I am investigating the role of Cep120, a potential key player in the processes of centriole biogenesis and ciliogenesis."},{"lastName":"Citri","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8759&type=small&showNoImage","displayName":"Amihai Citri","firstName":"Amihai","href":"http://med.stanford.edu/profiles/Amihai_Citri","researchInterest":""},{"lastName":"Lu","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","displayName":"Bingwei Lu","firstName":"Bingwei","href":"http://med.stanford.edu/profiles/Bingwei_Lu","researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Fuller","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4159&type=small&showNoImage","displayName":"Margaret T. Fuller","firstName":"Margaret","href":"http://med.stanford.edu/profiles/Margaret_Fuller","researchInterest":"Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis."},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration."},{"lastName":"Straight","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","displayName":"Aaron Straight","firstName":"Aaron","href":"http://med.stanford.edu/profiles/Aaron_Straight","researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis."},{"lastName":"Denko","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4577&type=small&showNoImage","displayName":"Nicholas Denko","firstName":"Nicholas","href":"http://med.stanford.edu/profiles/Nicholas_Denko","researchInterest":"We are interested in the biologic effect of gene expression changes that occur in the solid tumor.  Many of these expression changes are due to the micro-physiology within the tumor.  Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention.  We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes."},{"lastName":"Krieg","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9143&type=small&showNoImage","displayName":"Adam Krieg","firstName":"Adam","href":"http://med.stanford.edu/profiles/Adam_Krieg","researchInterest":""},{"lastName":"Scott","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","displayName":"Matthew Scott","firstName":"Matthew","href":"http://med.stanford.edu/profiles/Matthew_Scott","researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size."},{"lastName":"Rothenberg","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10397&type=small&showNoImage","displayName":"Michael Rothenberg","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Rothenberg","researchInterest":""},{"lastName":"Razorenova","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9869&type=small&showNoImage","displayName":"Olga Razorenova","firstName":"Olga","href":"http://med.stanford.edu/profiles/Olga_Razorenova","researchInterest":""},{"lastName":"Sweet-Cordero","clinicalFocus":[{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Assistant Professor,Pediatrics - Cancer Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Pediatrics - Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6970&type=small&showNoImage","displayName":"Alejandro Sweet-Cordero","firstName":"Alejandro","href":"http://med.stanford.edu/profiles/Alejandro_Sweet-Cordero","researchInterest":"Our laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer.   Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels."},{"lastName":"Axelrod","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","displayName":"Jeffrey Axelrod","firstName":"Jeffrey","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Attardi","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3851&type=small&showNoImage","displayName":"Laura Attardi","firstName":"Laura","href":"http://med.stanford.edu/profiles/Laura_Attardi","researchInterest":"Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse."},{"lastName":"Fan","clinicalFocus":[{"focus":"Medical Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Instructor,Medicine - Oncology"}],"primaryAppointment":"Instructor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7543&type=small&showNoImage","displayName":"Alice Fan","firstName":"Alice","href":"http://med.stanford.edu/profiles/Alice_Fan","researchInterest":"Dr. Fan studies how turning off oncogenes (cancer genes) can cause tumor regression in preclinical and clinical studies. Based on preclinical findings, she has initiated a clinical trial studying atorvastatin for the treatment of patients with certain non-Hodgkin's lymphomas. In the laboratory, she also uses preclinical models of cancer to validate new nanotechnology strategies for tumor diagnosis and treatment."},{"lastName":"Vladar","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"primaryAppointment":"Postdoctoral Research fellow, Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9267&type=small&showNoImage","displayName":"Eszter K. Vladar","firstName":"Eszter","href":"http://med.stanford.edu/profiles/Eszter_Vladar","researchInterest":""}]}