{"result":[{"lastName":"Prince","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4531&type=small&showNoImage","displayName":"David Prince","firstName":"David","href":"http://med.stanford.edu/profiles/David_Prince","researchInterest":"Experiments examine \r\n1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability\r\n2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors; \r\n3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.\r\n4. prophylaxis of postraumatic epilepsy\r\n5. Neocortical interneuronal function/modulation"},{"lastName":"Huguenard","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4124&type=small&showNoImage","displayName":"John Huguenard","firstName":"John","href":"http://med.stanford.edu/profiles/John_Huguenard","researchInterest":"We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks."},{"lastName":"McConnell","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5928&type=small&showNoImage","displayName":"Susan McConnell","firstName":"Susan","href":"http://med.stanford.edu/profiles/Susan_McConnell","researchInterest":"The McConnell Lab studies the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex.  Our work focuses on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate."},{"lastName":"Huberman","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9622&type=small&showNoImage","displayName":"Andrew D. Huberman","firstName":"Andrew","href":"http://med.stanford.edu/profiles/Andrew_Huberman","researchInterest":"Development and regeneration of the visual system"},{"lastName":"Penn","clinicalFocus":[{"focus":"Neonatal-Perinatal Medicine"}],"appointments":[{"appointment":"Assistant Professor,Pediatrics - Neonatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pediatrics - Neonatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4030&type=small&showNoImage","displayName":"Anna Penn","firstName":"Anna","href":"http://med.stanford.edu/profiles/Anna_Penn","researchInterest":"The Penn lab is studying the role of placental factors in brain development.  We are using novel mouse models to explore factors that contribute to normal neurodevelopment and the effects of their loss following premature birth.  We are focused on the influence of steroid hormones (estrogens and progestins) on cerebellar development and, collaboratively, are extending our studies to hippocampal stem cells and forebrain neurons."},{"lastName":"Barres","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurobiology"},{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Ophthalmology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor,Developmental Biology"}],"primaryAppointment":"Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4239&type=small&showNoImage","displayName":"Ben Barres","firstName":"Ben","href":"http://med.stanford.edu/profiles/Ben_Barres","researchInterest":"Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system."},{"lastName":"Malenka","clinicalFocus":[],"appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"}],"primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4670&type=small&showNoImage","displayName":"Robert Malenka","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Malenka","researchInterest":"Long-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy."},{"lastName":"Goddard","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8925&type=small&showNoImage","displayName":"Carson Goddard","firstName":"Carson","href":"http://med.stanford.edu/profiles/Carson_Goddard","researchInterest":""},{"lastName":"Chandrasekaran","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8816&type=small&showNoImage","displayName":"Anand Chandrasekaran","firstName":"Anand","href":"http://med.stanford.edu/profiles/Anand_Chandrasekaran","researchInterest":""},{"lastName":"Longo","clinicalFocus":[{"focus":"Neurology"},{"focus":"Alzheimer's Disease"},{"focus":"Huntington Disease"}],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7249&type=small&showNoImage","displayName":"Frank M. Longo, M.D., Ph.D.","firstName":"Frank","href":"http://med.stanford.edu/profiles/Frank_Longo","researchInterest":"Clinical interests include Alzheimer\u0092s disease and Huntington\u0092s disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders."},{"lastName":"Madison","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Associate Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4321&type=small&showNoImage","displayName":"Daniel V. Madison","firstName":"Vernon","href":"http://med.stanford.edu/profiles/Vernon_Madison","researchInterest":"Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system."},{"lastName":"MacIver","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4009&type=small&showNoImage","displayName":"M Bruce MacIver","firstName":"M","href":"http://med.stanford.edu/profiles/M_MacIver","researchInterest":"We study drug effects on the nervous system. Cellular, synaptic and molecular drug actions are investigated using electrophysiological and pharmacological tools in cortical/hippocampal brain slice preparations. We are also interested in mechanisms of neuronal integration and synchronization, especially related to patterns of EEG activity seen in vivo and in brain slices."},{"lastName":"Garner","clinicalFocus":[],"appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3890&type=small&showNoImage","displayName":"Craig C. Garner","firstName":"Craig","href":"http://med.stanford.edu/profiles/Craig_Garner","researchInterest":"Our laboratory is studying synapse formation, stability and elimination at a variety of levels, e.g. from molecules to behavior.  A primary focus of the lab is to understanding the role that individual molecules play in the assembly and function of synaptic junctions.  In addition we evaluating a variety of potential treatments for cognitive impairment in Down syndrome in part by assessing the impact specific drugs on cognitive function in mouse models of Down syndrome."},{"lastName":"Baccus","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6027&type=small&showNoImage","displayName":"Stephen A. Baccus","firstName":"Stephen","href":"http://med.stanford.edu/profiles/Stephen_Baccus","researchInterest":"We study how the neural circuitry of the vertebrate retina encodes visual scenes. We use a combination of experimental and theoretical methods, including multielectrode extracellular array recording, intracellular recording, two-photon laser scanning imaging, and computational modelling."},{"lastName":"Hestrin","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Comparative Medicine"}],"primaryAppointment":"Associate Professor,Comparative Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4343&type=small&showNoImage","displayName":"Shaul Hestrin","firstName":"Shaul","href":"http://med.stanford.edu/profiles/Shaul_Hestrin","researchInterest":"The main interest of my lab is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. Our approach includes recordings from multiple cells, calcium imaging, two-photon imaging and viral-based optogenetic methods to activate  cortical neurons as well as cortical afferents."},{"lastName":"Sudhof","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Psychiatry & Behavioral Science"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8533&type=small&showNoImage","displayName":"Thomas Sudhof","firstName":"Thomas","href":"http://med.stanford.edu/profiles/Thomas_Sudhof","researchInterest":"Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice."},{"lastName":"de Lecea","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7308&type=small&showNoImage","displayName":"Luis de Lecea","firstName":"Luis","href":"http://med.stanford.edu/profiles/Luis_de Lecea","researchInterest":"Our group initially identified the hypocretins, two hypothalamic neuropeptides that have a key role in maintaining the states of vigilance. We also discovered cortistatin, a peptide that modulates cortical excitability. My lab uses molecular, pharmacological, anatomical and behavioral methods to identify new roles for these transmitters. We are also interested in the cellular and molecular mechanisms by which neuronal systems integrate homeostatic information and regulate complex behaviors."},{"lastName":"Sohal","clinicalFocus":[{"focus":"Psychiatry"}],"appointments":[{"appointment":"Instructor,Psychiatry & Behavioral Science - Psychopharmacology"}],"primaryAppointment":"Instructor,Psychiatry & Behavioral Science - Psychopharmacology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10396&type=small&showNoImage","displayName":"Vikaas Sohal","firstName":"Vikaas","href":"http://med.stanford.edu/profiles/Vikaas_Sohal","researchInterest":""},{"lastName":"Tsien","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","displayName":"Richard Tsien","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Tsien","researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology."},{"lastName":"Shooter","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Neurobiology"}],"primaryAppointment":"Emeritus (Active) Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3996&type=small&showNoImage","displayName":"Eric Shooter","firstName":"Eric","href":"http://med.stanford.edu/profiles/Eric_Shooter","researchInterest":"The biochemistry and molecular genetics of growth and differentiation of nerve cells. The structure, biosynthesis and mechanism of action of nerve growth factor and other neurotrophins. Gene regulation in target organs and glial cells during nerve regeneration. The role of apolipoproteins and of the myelin protein PMP-22 during nerve degeneration and regeneration and in peripheral neuropathies."},{"lastName":"Deisseroth","clinicalFocus":[{"focus":"Psychiatry"}],"appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Associate Professor,Psychiatry & Behavioral Science"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6080&type=small&showNoImage","displayName":"Karl Deisseroth","firstName":"Karl","href":"http://med.stanford.edu/profiles/Karl_Deisseroth","researchInterest":"Research in Dr. Deisseroth's laboratory focuses on developing optical, molecular and cellular tools to observe, perturb, and re-engineer brain circuits. His laboratory is based in the James H. Clark Center at Stanford and has developed optogenetic and tissue engineering methods, employing techniques spanning electrophysiology, molecular biology, optics, neural activity imaging, animal behavior, and computational neural network modeling."},{"lastName":"Pang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9396&type=small&showNoImage","displayName":"Zhiping Pang","firstName":"Zhiping","href":"http://med.stanford.edu/profiles/Zhiping_Pang","researchInterest":""},{"lastName":"Witten","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10462&type=small&showNoImage","displayName":"Ilana Witten","firstName":"Ilana","href":"http://med.stanford.edu/profiles/Ilana_Witten","researchInterest":""},{"lastName":"Darian-Smith","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Comparative Medicine"}],"primaryAppointment":"Associate Professor,Comparative Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5979&type=small&showNoImage","displayName":"Corinna Darian-Smith","firstName":"Corinna","href":"http://med.stanford.edu/profiles/Corinna_Darian-Smith","researchInterest":"My lab looks at the organization and function of central neural pathways that underlie directed manual behavior.  We are specifically interested in how these pathways adapt following injury, and use a combination of approaches in monkeys to identify mechanisms mediating neural reorganization and behavioral recovery."},{"lastName":"Moore","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3946&type=small&showNoImage","displayName":"Tirin Moore","firstName":"Tirin","href":"http://med.stanford.edu/profiles/Tirin_Moore","researchInterest":"We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and"}]}