{"result":[{"researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Irving_Weissman","appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Irving","primaryAppointment":"Professor,Pathology - Stem Cell Institute","displayName":"Irving Weissman","lastName":"Weissman"},{"researchInterest":"Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4490&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Edgar_Engleman","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"firstName":"Edgar","primaryAppointment":"Professor,Pathology","displayName":"Edgar Engleman","lastName":"Engleman"},{"researchInterest":"Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4152&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samuel_Strober","appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"firstName":"Samuel","primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","displayName":"Samuel Strober","lastName":"Strober"},{"researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC).","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Leonard_Herzenberg","appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Leonard","primaryAppointment":"Emeritus (Active) Professor,Genetics","displayName":"Leonard Herzenberg","lastName":"Herzenberg"},{"researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Leonore_Herzenberg","appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Leonore","primaryAppointment":"Professor (Research),Genetics","displayName":"Leonore A. Herzenberg","lastName":"Herzenberg"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8761&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ching-Cheng_Chen","appointments":[{"appointment":"Instructor,Pathology"}],"clinicalFocus":[],"firstName":"Ching-Cheng","primaryAppointment":"Instructor,Pathology","displayName":"Ching-Cheng Chen","lastName":"Chen"},{"researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome.  Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","href":"http://med.stanford.edu/profiles/C_Fathman","appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"firstName":"C","primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","displayName":"C. Garrison Fathman","lastName":"Fathman"},{"researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jane_Parnes","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jane","primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","displayName":"Jane Parnes","lastName":"Parnes"},{"researchInterest":"Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.  Dynamics and functionality of specific T cell populations in human cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4282&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Davis","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Mark M. Davis","lastName":"Davis"},{"researchInterest":"Embryonic stem cell differentiation, angiogenesis","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8756&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Zongjin_Li","appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"clinicalFocus":[],"firstName":"Zongjin","primaryAppointment":"Postdoctoral Research fellow, Radiology","displayName":"Zongjin Li","lastName":"Li"},{"researchInterest":"My laboratory has two major research interests.  First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.  Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Lewis","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"firstName":"David","primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","displayName":"David B. Lewis","lastName":"Lewis"},{"researchInterest":"My recent research efforts are currently focused in the field of applications of immunohistology to the diagnosis of human neoplasms. This work is predominantly aimed at characterizing markers for the identification of non-lymphoid neoplasms and at establishing criteria for their evaluation in diagnostic situations.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4491&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Rouse","appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Robert","primaryAppointment":"Professor - Med Center Line,Pathology","displayName":"Robert V Rouse","lastName":"Rouse"},{"researchInterest":"Dr. Chen's research focus includes various advanced therapeutic endoscopic procedures with focus on premalignant and malignant gastrointestinal diseases. Specifically, she is interested in early detection and treatment of pancreatic-biliary and gastrointestinal diseases utilizing interventional procedures such as endoscopic ultrasound, radiofrequency and cryoablation therapy, confocal microscopy, and small bowel enteroscopy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10886&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ann_Chen","appointments":[{"appointment":"Clinical Assistant Professor,Medicine - Gastroenterology & Hepatology"}],"clinicalFocus":[{"focus":"Gastroenterology"},{"focus":"Endoscopic Ultrasonography"},{"focus":"pancreatic cancer"},{"focus":"Pancreatitis"},{"focus":"Pancreatic Cyst"},{"focus":"Gastric Cancer"},{"focus":"Esophageal Cancer"},{"focus":"Rectal Cancer"},{"focus":"Barrett Esophagus"},{"focus":"Advanced Endoscopy"}],"firstName":"Ann","primaryAppointment":"Clinical Assistant Professor,Medicine - Gastroenterology & Hepatology","displayName":"Ann Chen","lastName":"Chen"},{"researchInterest":"Our research interests are primarily in surgical oncology, especially gastrointestinal cancers. We are also developing new research studies in surgical outcomes.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4440&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sherry_Wren","appointments":[{"appointment":"Professor - Med Center Line,Surgery - General Surgery"}],"clinicalFocus":[{"focus":"Surgical Oncology"},{"focus":"Colorectal Surgery"},{"focus":"General Surgery"}],"firstName":"Sherry","primaryAppointment":"Professor - Med Center Line,Surgery - General Surgery","displayName":"Sherry M. Wren","lastName":"Wren"},{"researchInterest":"Our laboratory focuses on host-viral interactions in the sexual and mother-to-child transmission of HIV-1. We developed human organotypic models to closely mimic in vivo infection. Our recent work has focused on developing immune-based and small molecule inhibitors of HIV-1 transmission.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3975&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bruce_Patterson","appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Associate Professor - Med Center Line (By courtesy),Medicine"}],"clinicalFocus":[],"firstName":"Bruce","primaryAppointment":"Associate Professor - Med Center Line,Pathology","displayName":"Bruce Patterson","lastName":"Patterson"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3884&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Clark_Bonham","appointments":[{"appointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"General Surgery"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Liver Transplantation"}],"firstName":"Clark","primaryAppointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation","displayName":"Clark Bonham","lastName":"Bonham"},{"researchInterest":"Our interests include: \r\n1) The physiology and significance of lymphocyte homing in local and systemic immunity; \r\n2) biochemical and genetic studies of molecules that direct leukocyte recruitment; \r\n3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; \r\n4) vascular differentiation in normal and pathologic inflammatory states; \r\n5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4498&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Eugene_Butcher","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Eugene","primaryAppointment":"Professor,Pathology","displayName":"Eugene Butcher","lastName":"Butcher"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"My lab works on biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging technologies to better understand stem cell biology in vitro and in vivo.  For adult stem cells, we are interested in monitoring stem cell survival, proliferation, and differentiation. For ESC, we are currently studying their tumorigenicity, immunogenicity, and differentiation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6159&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joseph_Wu","appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine"},{"appointment":"Assistant Professor - Med Center Line,Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Congenital Heart Disease (Adult)"},{"focus":"Echocardiography"}],"firstName":"Joseph","primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine","displayName":"Joseph  C. Wu","lastName":"Wu"},{"researchInterest":"Lymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4707&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sara_Michie","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Anatomic Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"firstName":"Sara","primaryAppointment":"Professor,Pathology","displayName":"Sara Michie","lastName":"Michie"},{"researchInterest":"Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4121&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yueh-Hsiu_Chien","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Yueh-Hsiu","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Yueh-hsiu Chien","lastName":"Chien"},{"researchInterest":"Our labaratory focuses on the study of immune recognition by T and NK cells with special emphasis on graft vs host disease and graft vs tumor reactions. We utilize both murine and human systems in an effort to enhance graft vs tumor reactions while controlling graft vs host disease. We have developed bioluminescence models in collaboration with the Contag laboratory to study the trafficking of immune effector cells with a special emphasis on NK, T and regulatory T cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4138&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Negrin","appointments":[{"appointment":"Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Blood and Marrow Transplantation"},{"focus":"Hematology"}],"firstName":"Robert","primaryAppointment":"Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation","displayName":"Robert Negrin","lastName":"Negrin"},{"researchInterest":"Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4307&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Shoshana_Levy","appointments":[{"appointment":"Professor (Research),Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Shoshana","primaryAppointment":"Professor (Research),Medicine - Oncology","displayName":"Shoshana Levy","lastName":"Levy"},{"researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Clarke","appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Michael","primaryAppointment":"Professor,Medicine - Oncology","displayName":"Michael F. Clarke, M.D.","lastName":"Clarke"},{"researchInterest":"We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in \"a vacuum\" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4036&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Christopher_Contag","appointments":[{"appointment":"Associate Professor,Pediatrics - Neonatology"},{"appointment":"Associate Professor,Microbiology & Immunology"},{"appointment":"Associate Professor (By courtesy),Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Christopher","primaryAppointment":"Associate Professor,Pediatrics - Neonatology","displayName":"Christopher H. Contag","lastName":"Contag"}]}