{"result":[{"researchInterest":"The auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7527&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anthony_Ricci","appointments":[{"appointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)"},{"appointment":"Associate Professor (By courtesy),Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Anthony","primaryAppointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)","displayName":"Anthony Ricci","lastName":"Ricci"},{"researchInterest":"Sensorineural hearing loss affects more than 30 million people worldwide and the most common underlying pathology is loss of sensory hair cells, the mechanoreceptors of the inner ear.  Loss of these specialized cells is permanent in mammals and regeneration is limited/non-existent.  Recently stem cell-like cells have been isolated from the mammalian inner ears.\r\n\r\nOur research group is interested in identifying signals that maintain the stem cell population and the stem cell niche in the mammal","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8272&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Alan_Cheng","appointments":[{"appointment":"Assistant Professor,Otolaryngology (Head and Neck Surgery)"}],"clinicalFocus":[{"focus":"Otolaryngology"},{"focus":"Otolaryngology - Head & Neck Surgery (Ear, Nose and Throat)"},{"focus":"Cholesteotoma"},{"focus":"Hearing loss"},{"focus":"Branchial Cleft Cyst"},{"focus":"Head and Neck Neoplasms"}],"firstName":"Alan","primaryAppointment":"Assistant Professor,Otolaryngology (Head and Neck Surgery)","displayName":"Alan G. Cheng","lastName":"Cheng"},{"researchInterest":"We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels.  We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3813&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Miriam_Goodman","appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Miriam","primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","displayName":"Miriam B. Goodman","lastName":"Goodman"},{"researchInterest":"Clinical interests include Alzheimer\u0092s disease and Huntington\u0092s disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7249&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Frank_Longo","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"clinicalFocus":[{"focus":"Neurology"},{"focus":"Alzheimer's Disease"},{"focus":"Huntington Disease"}],"firstName":"Frank","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"Frank M. Longo, M.D., Ph.D.","lastName":"Longo"},{"researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jeffrey","primaryAppointment":"Associate Professor,Pathology","displayName":"Jeffrey Axelrod","lastName":"Axelrod"},{"researchInterest":"For most areas of the mammalian brain, neurogenesis concludes at birth but there are exceptions to the rule. In rodents and humans, some areas of the brain continue to make new neurons throughout life. This process is mediated by neural stem cells and our research goals are to understand how stem cell activity is regulated and whether the nascent potential of resident stem cells can be harnessed for brain repair.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5930&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Theo_Palmer","appointments":[{"appointment":"Associate Professor,Neurosurgery"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Theo","primaryAppointment":"Associate Professor,Neurosurgery","displayName":"Theo Palmer","lastName":"Palmer"},{"researchInterest":"Our laboratory is studying synapse formation, stability and elimination at a variety of levels, e.g. from molecules to behavior.  A primary focus of the lab is to understanding the role that individual molecules play in the assembly and function of synaptic junctions.  In addition we evaluating a variety of potential treatments for cognitive impairment in Down syndrome in part by assessing the impact specific drugs on cognitive function in mouse models of Down syndrome.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3890&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Craig_Garner","appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"Craig","primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","displayName":"Craig C. Garner","lastName":"Garner"},{"researchInterest":"The biochemistry and molecular genetics of growth and differentiation of nerve cells. The structure, biosynthesis and mechanism of action of nerve growth factor and other neurotrophins. Gene regulation in target organs and glial cells during nerve regeneration. The role of apolipoproteins and of the myelin protein PMP-22 during nerve degeneration and regeneration and in peripheral neuropathies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3996&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Eric_Shooter","appointments":[{"appointment":"Emeritus (Active) Professor,Neurobiology"}],"clinicalFocus":[],"firstName":"Eric","primaryAppointment":"Emeritus (Active) Professor,Neurobiology","displayName":"Eric Shooter","lastName":"Shooter"},{"researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matthew_Scott","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Matthew","primaryAppointment":"Professor,Developmental Biology","displayName":"Matthew Scott","lastName":"Scott"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10159&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Andrew_Yoo","appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"clinicalFocus":[],"firstName":"Andrew","primaryAppointment":"Postdoctoral Research fellow, Pathology","displayName":"Andrew Yoo","lastName":"Yoo"},{"researchInterest":"Our laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis.  We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3938&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Chen","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Assistant Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"James K. Chen","lastName":"Chen"},{"researchInterest":"Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4239&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ben_Barres","appointments":[{"appointment":"Professor,Neurobiology"},{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Ophthalmology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor,Developmental Biology"}],"clinicalFocus":[],"firstName":"Ben","primaryAppointment":"Professor,Neurobiology","displayName":"Ben Barres","lastName":"Barres"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8533&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Sudhof","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Psychiatry & Behavioral Science"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Thomas Sudhof","lastName":"Sudhof"},{"researchInterest":"Dr. Helms' research interests center around craniofacial development and regenerative medicine.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6152&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jill_Helms","appointments":[{"appointment":"Associate Professor,Surgery - Plastic/Recon Surgery"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Jill","primaryAppointment":"Associate Professor,Surgery - Plastic/Recon Surgery","displayName":"Jill Helms","lastName":"Helms"},{"researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roeland_Nusse","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Roeland","primaryAppointment":"Professor,Developmental Biology","displayName":"Roeland Nusse","lastName":"Nusse"},{"researchInterest":"Epigenetic Reprogramming, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10445&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Marius_Wernig","appointments":[{"appointment":"Assistant Professor,Pathology - Stem Cell Institute"}],"clinicalFocus":[],"firstName":"Marius","primaryAppointment":"Assistant Professor,Pathology - Stem Cell Institute","displayName":"Marius Wernig","lastName":"Wernig"},{"researchInterest":"We study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as \"self\" versus \"nonself\" or \"wanted\" versus \"unwanted\".","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3989&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Andrew_Fire","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"Andrew","primaryAppointment":"Professor,Pathology","displayName":"Andrew Fire","lastName":"Fire"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9345&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ben_Emery","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Ben","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Ben Emery","lastName":"Emery"},{"researchInterest":"I am interested in understanding the signaling pathways that regulate the development of specialized tight junctions in brain endothelial cells responsible for forming the blood-brain barrier. The identification of these signals is important for elucidating the mechanisms that regulate the entry of distinct compounds or drugs into the Central Nervous System (CNS) and the etiology of pathological CNS conditions associated with blood-brain barrier breakdown.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9742&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dritan_Agalliu","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Dritan","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Dritan Agalliu PhD","lastName":"Agalliu"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9884&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mara_Schvarzstein","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Mara","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Mara Schvarzstein","lastName":"Schvarzstein"},{"researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Tsien","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Tsien","lastName":"Tsien"},{"researchInterest":"The McConnell Lab studies the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex.  Our work focuses on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5928&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Susan_McConnell","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Susan","primaryAppointment":"Member,Bio-X","displayName":"Susan McConnell","lastName":"McConnell"},{"researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Howard_Chang","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"Howard","primaryAppointment":"Associate Professor,Dermatology","displayName":"Howard Y. Chang","lastName":"Chang"},{"researchInterest":"Hedgehog signaling has been implicated in the induction or maintenance of up to 25% of human tumors and a variety of birth defects.  Our lab studies Sonic hedgehog (Shh) signaling in normal hair follicle development and in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin.  We are interested in how the local stromal environment regulates hedgehog signaling and hair follicle or tumor growth and invasion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4693&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anthony_Oro","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"},{"focus":"Skin Cancer "},{"focus":"Hair disorders"}],"firstName":"Anthony","primaryAppointment":"Associate Professor,Dermatology","displayName":"Anthony Oro  MD/PhD","lastName":"Oro"}]}