{"result":[{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4159&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Margaret_Fuller","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Margaret","primaryAppointment":"Professor,Developmental Biology","displayName":"Margaret T. Fuller","lastName":"Fuller"},{"researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Aaron_Straight","appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Aaron","primaryAppointment":"Assistant Professor,Biochemistry","displayName":"Aaron Straight","lastName":"Straight"},{"researchInterest":"We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6244&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tim_Stearns","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Tim","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Tim Stearns","lastName":"Stearns"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"Cell cycle and cyclin control of DNA replication .","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4463&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Jackson","appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Peter","primaryAppointment":"Member,Cancer Center","displayName":"Peter Jackson","lastName":"Jackson"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15112&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Hunter_Fraser","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Hunter","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Hunter Fraser","lastName":"Fraser"},{"researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6213&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martha_Cyert","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Martha","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Martha Cyert","lastName":"Cyert"},{"researchInterest":"The general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement and changes in cell shape.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4609&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Spudich","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Professor,Biochemistry","displayName":"James Spudich","lastName":"Spudich"},{"researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Maxence_Nachury","appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Maxence","primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","displayName":"Maxence Nachury","lastName":"Nachury"},{"researchInterest":"The focus of my group is the application of bioinformatics to the collection and dissemination genetic, genomic and cellular  information. We abstracts the published results into our database, SGD. We explore the volumes of information that have been elucidated for the budding yeast S. cerevisiae.  My research is the applied use computers and databases: designing a resource to effectively provide biological information to the research community, and the development of the Gene Ontology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4249&type=small&showNoImage","href":"http://med.stanford.edu/profiles/JMichael_Cherry","appointments":[{"appointment":"Associate Professor (Research),Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"JMichael","primaryAppointment":"Associate Professor (Research),Genetics","displayName":"Mike Cherry","lastName":"Cherry"},{"researchInterest":"The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they are localized to distinct intracellular compartments in human cells, and how they serve as master regulators of all receptor trafficking events.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4087&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Suzanne_Pfeffer","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Suzanne","primaryAppointment":"Professor,Biochemistry","displayName":"Suzanne Pfeffer","lastName":"Pfeffer"},{"researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matthew_Scott","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Matthew","primaryAppointment":"Professor,Developmental Biology","displayName":"Matthew Scott","lastName":"Scott"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8699&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jerry_Hsu","appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"clinicalFocus":[],"firstName":"Jerry","primaryAppointment":"Postdoctoral Medical fellow, Medicine","displayName":"Jerry Hsu","lastName":"Hsu"},{"researchInterest":"Genetic and molecular basis of respiratory system  development, maintenance, and disease in Drosophila, mouse, and human","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Krasnow","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Biochemistry","displayName":"Mark Krasnow","lastName":"Krasnow"},{"researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Ferrell","appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Professor,Chemical and Systems Biology","displayName":"James Ferrell","lastName":"Ferrell"},{"researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bingwei_Lu","appointments":[{"appointment":"Assistant Professor,Pathology"}],"clinicalFocus":[],"firstName":"Bingwei","primaryAppointment":"Assistant Professor,Pathology","displayName":"Bingwei Lu","lastName":"Lu"},{"researchInterest":"The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4110&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Teresa_Wang","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Teresa","primaryAppointment":"Professor,Pathology","displayName":"Teresa Wang","lastName":"Wang"},{"researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Cohen","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Genetics","displayName":"Stanley N. Cohen, MD","lastName":"Cohen"},{"researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Berg","appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Emeritus (Active) Professor,Biochemistry","displayName":"Paul Berg","lastName":"Berg"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10605&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sean_Collins","appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"clinicalFocus":[],"firstName":"Sean","primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","displayName":"Sean Collins","lastName":"Collins"},{"researchInterest":"We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4308&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roger_Kornberg","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Roger","primaryAppointment":"Professor,Structural Biology","displayName":"Roger Kornberg","lastName":"Kornberg"},{"researchInterest":"A central aim of the burgeoning field of systems biology is to understand the principles governing genetic control networks. I believe finding the principles underlying genetic circuits will occur through detailed studies and then comparisons of several natural systems. Due to its extensive development as an experimental system, our favorite model, the budding yeast cell cycle, is poised to become central to this enterprise.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10452&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jan_Skotheim","appointments":[{"appointment":"Assistant Professor (By courtesy),Chemical and Systems Biology"},{"appointment":" (By courtesy),Chemical and Systems Biology"},{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Jan","primaryAppointment":"Assistant Professor (By courtesy),Chemical and Systems Biology","displayName":"Jan Skotheim","lastName":"Skotheim"},{"researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jeffrey","primaryAppointment":"Associate Professor,Pathology","displayName":"Jeffrey Axelrod","lastName":"Axelrod"}]}