{"result":[{"lastName":"Mochly-Rosen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4256&type=small&showNoImage","displayName":"Daria Mochly-Rosen","firstName":"Daria","href":"http://med.stanford.edu/profiles/Daria_Mochly-Rosen","researchInterest":"Two areas:  1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling.  We focus on protein kinase C (PKC)-mediated signal transduction and on mitochondrial dynamics in several disease models. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, we study their involvement  in normal cells and in models of human diseases."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Edward","clinicalFocus":[],"appointments":[{"appointment":"Part-Time Professional,Otolaryngology (Head and Neck Surgery)"}],"primaryAppointment":"Part-Time Professional,Otolaryngology (Head and Neck Surgery)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19789&type=small&showNoImage","displayName":"Justin Edward","firstName":"Justin","href":"http://med.stanford.edu/profiles/Justin_Edward","researchInterest":""},{"lastName":"Menard","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=16879&type=small&showNoImage","displayName":"Frederic Menard","firstName":"Frederic","href":"http://med.stanford.edu/profiles/Frederic_Menard","researchInterest":"My research focuses on understanding how voltage-gated Na+ channels function at the molecular level. Specifically, I use natural products such as aconitine and batrachotoxin as molecular probes to identify key protein interactions that are responsible for the healthy behaviour of the channels. In addition, synthetic modification of the natural products allow us to design molecular tools for applications that range from real-time protein imaging to next generation pain treatments."},{"lastName":"Khosla","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical Engineering - Chemical Engineering Operations"},{"appointment":"Professor,Natural Sciences Cluster - Chemistry"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Biochemistry"}],"primaryAppointment":"Professor,Chemical Engineering - Chemical Engineering Operations","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9633&type=small&showNoImage","displayName":"Chaitan Khosla","firstName":"Chaitan","href":"http://med.stanford.edu/profiles/Chaitan_Khosla","researchInterest":"Research interests in this laboratory lie at the interface of chemistry and medicine.\r\n\r\nFor the past several years, we have investigated the catalytic mechanisms of modular megasynthases such as polyketide synthases, with the concomitant goal of harnessing their programmable chemistry for preparing new antibiotics. Recent accomplishments include methods for heterologous production of polyketides; genetically reprogrammed biosynthesis of anthraquinones and polypropionates; and chemo-biosynthesi"},{"lastName":"Crowe","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23694&type=small&showNoImage","displayName":"Chris Crowe","firstName":"Christopher","href":"http://med.stanford.edu/profiles/Christopher_Crowe","researchInterest":""},{"lastName":"Barron","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8312&type=small&showNoImage","displayName":"Annelise E. Barron","firstName":"Annelise","href":"http://med.stanford.edu/profiles/Annelise_Barron","researchInterest":"Biophysical mechanisms of host defense peptides and their mimics"},{"lastName":"Zaleta Rivera","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10991&type=small&showNoImage","displayName":"Kathia Zaleta, PhD","firstName":"Kathia","href":"http://med.stanford.edu/profiles/Kathia_Zaleta Rivera","researchInterest":""},{"lastName":"O'keefe","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Natural Sciences Cluster"}],"primaryAppointment":"Postdoctoral Research fellow, Natural Sciences Cluster","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19161&type=small&showNoImage","displayName":"B. Michael O'Keefe","firstName":"Brian","href":"http://med.stanford.edu/profiles/Brian_O'keefe","researchInterest":""},{"lastName":"Ouyang","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20219&type=small&showNoImage","displayName":"Xiaohu \"Shawn\" Ouyang","firstName":"Xiaohu","href":"http://med.stanford.edu/profiles/Xiaohu_Ouyang","researchInterest":"Chemical Biology and Tissue Regeneration"},{"lastName":"Gelman","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Infectious Diseases"}],"primaryAppointment":"Instructor,Medicine - Infectious Diseases","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13452&type=small&showNoImage","displayName":"Michael A. Gelman","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Gelman","researchInterest":"Hepatitis C virology, bio-organic chemistry, and chemical biology. My current work focuses on probing the interaction between the NS5A nonstructural protein of HCV and PIP2, a membrane lipid found in all cells. Disruption of this interaction appears to prevent HCV from replicating."},{"lastName":"Roizen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Natural Sciences Cluster"}],"primaryAppointment":"Postdoctoral Research fellow, Natural Sciences Cluster","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=16160&type=small&showNoImage","displayName":"Jennifer Roizen","firstName":"Jennifer","href":"http://med.stanford.edu/profiles/Jennifer_Roizen","researchInterest":""},{"lastName":"Sikic","clinicalFocus":[{"focus":"Medical Oncology"},{"focus":"New Drug Studies"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4131&type=small&showNoImage","displayName":"Branimir I. Sikic, M. D.","firstName":"Branimir","href":"http://med.stanford.edu/profiles/Branimir_Sikic","researchInterest":"Research Interests: cancer pharmacology, mechanisms of resistance to anticancer drugs, regulation and function of MDR1 and tubulin genes, clinical trials of modulation of drug resistance, general oncology, Phase I trials of new drugs, gene expression profiling of cancers"},{"lastName":"Sadaghiani","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19931&type=small&showNoImage","displayName":"A. Masoud Sadaghiani","firstName":"Amir","href":"http://med.stanford.edu/profiles/Amir_Sadaghiani","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Miyabe","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Natural Sciences Cluster"}],"primaryAppointment":"Postdoctoral Research fellow, Natural Sciences Cluster","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20883&type=small&showNoImage","displayName":"Shungo Miyabe","firstName":"Shungo","href":"http://med.stanford.edu/profiles/Shungo_Miyabe","researchInterest":""},{"lastName":"Levitt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Computer Science"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","displayName":"Michael Levitt","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Levitt","researchInterest":"having pioneered, we (a) predict folding of a polypeptide and RNA chains into a unique native-structure, we (b) model protein structure using the well-established paradigms that similar protein sequences imply similar three-dimensional structures, and (c) we are focusing on mesoscale modeling of large macromolecular complexes such as RNA polymerase and the mammalian chaperonin."},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Doniach","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8062&type=small&showNoImage","displayName":"Sebastian Doniach","firstName":"Sebastian","href":"http://med.stanford.edu/profiles/Sebastian_Doniach","researchInterest":""},{"lastName":"Frimannsson","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19052&type=small&showNoImage","displayName":"Daniel Omar Frimannsson","firstName":"Daniel","href":"http://med.stanford.edu/profiles/Daniel_Frimannsson","researchInterest":"My main research projects are focused on the investigation of the therapeutic effect of a novel prodrug-enzyme anticancer therapy and the development of a magnetic resonance imaging system that would enable the assessment of tumor metastasis in vivo, starting from a single cell. I have gained valuable experience in molecular cloning, protein manufacture and protein purification. My previous research included the pre-clinical testing of various different fluorescent reporters, anticancer agents "},{"lastName":"Cochran","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Associate Professor (By courtesy),Chemical Engineering"}],"primaryAppointment":"Associate Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6393&type=small&showNoImage","displayName":"Jennifer R. Cochran","firstName":"Jennifer","href":"http://med.stanford.edu/profiles/Jennifer_Cochran","researchInterest":"Molecular Bioengineering, Protein Biochemistry and Biotechnology, Cell and Tissue Engineering, Molecular Imaging"},{"lastName":"Liu","clinicalFocus":[],"appointments":[{"appointment":"Engr Res Assoc,Genetics"}],"primaryAppointment":"Engr Res Assoc,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9027&type=small&showNoImage","displayName":"Tianyun Liu","firstName":"Tianyun","href":"http://med.stanford.edu/profiles/Tianyun_Liu","researchInterest":""},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Cheng","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology"}],"primaryAppointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8291&type=small&showNoImage","displayName":"Zhen Cheng","firstName":"Zhen","href":"http://med.stanford.edu/profiles/Zhen_Cheng","researchInterest":"To develop novel molecular imaging probes and techniques for non-invasively early detection of cancer using multimodality imaging technologies including PET, SPECT, MRI, optical imaging, etc."}]}