{"result":[{"researchInterest":"My research interest is focused on investigating the molecular networks that underlie cancer stem cells and designing therapies that selectively target these cells, thereby eliminating a cancer's potential for regrowth.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7991&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Wong","appointments":[{"appointment":"Instructor,Dermatology"},{"appointment":"Postdoctoral Research fellow, Dermatology"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"David","primaryAppointment":"Instructor,Dermatology","displayName":"David J. Wong, M.D., Ph.D.","lastName":"Wong"},{"researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Amato_Giaccia","appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Amato","primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","displayName":"Amato Giaccia","lastName":"Giaccia"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals.  We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies.  In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress.  We have now begun to characterize the molecular mechanisms b","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6623&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Katrin_Chua","appointments":[{"appointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Katrin","primaryAppointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab","displayName":"Katrin Chua","lastName":"Chua"},{"researchInterest":"We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease.  Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes.  We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6423&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Or_Gozani","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Or","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Or Gozani","lastName":"Gozani"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Clarke","appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Michael","primaryAppointment":"Professor,Medicine - Oncology","displayName":"Michael F. Clarke, M.D.","lastName":"Clarke"},{"researchInterest":"The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4506&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Cleary","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"},{"appointment":"Professor,Pediatrics"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Professor,Pathology","displayName":"Michael Cleary","lastName":"Cleary"},{"researchInterest":"We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4683&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Khavari","appointments":[{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Professor,Dermatology","displayName":"Paul A. Khavari, MD, PhD","lastName":"Khavari"},{"researchInterest":"My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5931&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dean_Felsher","appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hodgkin's Disease"},{"focus":"Hodgkin's Disease - Hematology"},{"focus":"Hodgkin's Disease - Medical Oncology"},{"focus":"Lymphoma "},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Dean","primaryAppointment":"Associate Professor,Medicine - Oncology","displayName":"Dean W. Felsher","lastName":"Felsher"},{"researchInterest":"We are interested in the biologic effect of gene expression changes that occur in the solid tumor.  Many of these expression changes are due to the micro-physiology within the tumor.  Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention.  We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4577&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Nicholas_Denko","appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Nicholas","primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Biology","displayName":"Nicholas Denko","lastName":"Denko"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kryn_Stankunas","appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Kryn","primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","displayName":"Kryn Stankunas","lastName":"Stankunas"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10153&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tao_Hong","appointments":[{"appointment":"Postdoctoral Research fellow, School of Medicine"}],"clinicalFocus":[],"firstName":"Tao","primaryAppointment":"Postdoctoral Research fellow, School of Medicine","displayName":"Tao Hong","lastName":"Hong"},{"researchInterest":"My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9248&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Maximilian_Diehn","appointments":[{"appointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy"}],"clinicalFocus":[],"firstName":"Maximilian","primaryAppointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy","displayName":"Maximilian Diehn, M.D., Ph.D.","lastName":"Diehn"},{"researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anne_Brunet","appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Anne","primaryAppointment":"Assistant Professor,Genetics","displayName":"Anne Brunet","lastName":"Brunet"},{"researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Linda_Boxer","appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"firstName":"Linda","primaryAppointment":"Professor,Medicine - Hematology","displayName":"Linda Boxer","lastName":"Boxer"},{"researchInterest":"Research in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7764&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joanna_Wysocka","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Assistant Professor,Developmental Biology"}],"clinicalFocus":[],"firstName":"Joanna","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"Joanna Wysocka","lastName":"Wysocka"},{"researchInterest":"Our laboratory uses genomics approaches to explore patterns of gene expression and gene copy number alteration in both human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6066&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jonathan_Pollack","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jonathan","primaryAppointment":"Associate Professor,Pathology","displayName":"Jonathan Pollack","lastName":"Pollack"},{"researchInterest":"Understanding genetic basis of cardiovascular function and disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Quertermous","appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","displayName":"Thomas Quertermous, MD","lastName":"Quertermous"},{"researchInterest":"The focus of our research is to determine the genomic and proteomic signatures of a cancer cell, and to compare them to the signatures of normal stem cells.  The goal is to identify the pathway(s) that determine the fate of a progenitor cell \u0096 to become neoplastic or to remain normal \u0096 then to prevent the neoplastic pathway decision.\r\n\r\nWe are also developing surface enhanced Raman (SERS) nanoparticles to supplement the fluorescent molecules currently available for flow cytometry.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7574&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Catherine_Shachaf","appointments":[{"appointment":"Instructor,Microbiology & Immunology - Baxter Laboratory"}],"clinicalFocus":[],"firstName":"Catherine","primaryAppointment":"Instructor,Microbiology & Immunology - Baxter Laboratory","displayName":"Catherine Shachaf","lastName":"Shachaf"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9968&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Denise_Chan","appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"clinicalFocus":[],"firstName":"Denise","primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","displayName":"Denise Chan","lastName":"Chan"},{"researchInterest":"Our research focuses on gene microarray analysis of human soft tissue tumors (sarcomas). In addition we work with tissue microarrays to characterize large numbers of novel antisera raised against peptides derived from genes found to be of interest during gene array analysis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4008&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matt_Van de Rijn","appointments":[{"appointment":"Professor - Med Center Line,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Matt","primaryAppointment":"Professor - Med Center Line,Pathology","displayName":"Matt Van de Rijn","lastName":"Van de Rijn"},{"researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Irving_Weissman","appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Irving","primaryAppointment":"Professor,Pathology - Stem Cell Institute","displayName":"Irving Weissman","lastName":"Weissman"},{"researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6213&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martha_Cyert","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Martha","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Martha Cyert","lastName":"Cyert"}]}