{"result":[{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"},{"appointment":"Professor Emeritus,SoM Dean's Office Administrative Units - Dean's Office Operations"},{"appointment":"Professor Emeritus,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab's research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Smith","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Radiation Oncology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7014&type=small&showNoImage","displayName":"Kendric C. Smith","firstName":"Kendric","href":"http://med.stanford.edu/profiles/Kendric_Smith","researchInterest":"The photochemistry and radiation chemistry of DNA, the genetic control and biochemical bases of the multiple pathways of DNA repair, and the roles of DNA repair processes in radiation and spontaneous mutagenesis. Over 190 papers have been published on these and related topics."},{"lastName":"Snyder","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13465&type=small&showNoImage","displayName":"Michael Snyder","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Snyder","researchInterest":"We are presently in an omics revolution in which genomes and other omes can be readily characterized. Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans.\r\n\r\n1) Transcriptomes\r\nTo annotate genomes, we developed RNA sequencing for annotation the yeast and human transcriptomes. We discovered that the eukaryotic transcriptome is much more complex than previously"},{"lastName":"Maeda","clinicalFocus":[{"focus":"Hematology/Oncology"}],"appointments":[{"appointment":"Clinical Assistant Professor,Medicine - Hematology"},{"appointment":"Clinical Assistant Professor,Medicine - Oncology"}],"primaryAppointment":"Clinical Assistant Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15802&type=small&showNoImage","displayName":"Lauren Maeda","firstName":"Lauren","href":"http://med.stanford.edu/profiles/Lauren_Maeda","researchInterest":""},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Morrison","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","displayName":"Ashby Morrison","firstName":"Ashby","href":"http://med.stanford.edu/profiles/Ashby_Morrison","researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity."},{"lastName":"Jarosz","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Assistant Professor,Developmental Biology"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=33778&type=small&showNoImage","displayName":"Daniel Jarosz","firstName":"Daniel","href":"http://med.stanford.edu/profiles/Daniel_Jarosz","researchInterest":"Survival in changing environments requires the acquisition of new heritable traits. However, mechanisms that safeguard the fidelity of DNA replication often limit the source of such novelty to relatively modest changes in the genetic code. Thus, the acquisition of new forms and functions is thought to be driven by rare variants that occur at random, and are enriched during times of stress. We have begun to study an intriguing alternative hypothesis: that intrinsic links between protein folding "},{"lastName":"Campbell","clinicalFocus":[],"appointments":[{"appointment":"Professor Emeritus,Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Professor Emeritus,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6212&type=small&showNoImage","displayName":"Allan Campbell","firstName":"Allan","href":"http://med.stanford.edu/profiles/Allan_Campbell","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Cherry","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4249&type=small&showNoImage","displayName":"Mike Cherry","firstName":"J. Michael","href":"http://med.stanford.edu/profiles/J. Michael_Cherry","researchInterest":"My research involves identifying, validating and integrating scientific facts into encyclopedic databases essential for research and scientific education.  Published results of scientific experimentation are a foundation of our understanding of the natural world and provide motivation for new experiments.  The combination of in-depth understanding reported in the literature with computational analyses is an essential ingredient of modern biological research."},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Francke","clinicalFocus":[{"focus":"Neurogenetics"},{"focus":"Clinical Genetics"}],"appointments":[{"appointment":"Professor Emeritus,Genetics"},{"appointment":"Emeritus Faculty, Acad Council,Genetics"},{"appointment":"Professor,Pediatrics - Medical Genetics"}],"primaryAppointment":"Professor Emeritus,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4281&type=small&showNoImage","displayName":"Uta Francke","firstName":"Uta","href":"http://med.stanford.edu/profiles/Uta_Francke","researchInterest":"Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models. Integration of genomic information into medical care."},{"lastName":"Lorch","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"primaryAppointment":"Associate Professor (Research),Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","displayName":"Yahli Lorch","firstName":"Yahli","href":"http://med.stanford.edu/profiles/Yahli_Lorch","researchInterest":""},{"lastName":"Porteus","clinicalFocus":[{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Associate Professor,Pediatrics - Cancer Biology"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Pediatrics - Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19354&type=small&showNoImage","displayName":"Matthew Porteus","firstName":"Matthew","href":"http://med.stanford.edu/profiles/Matthew_Porteus","researchInterest":""},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","displayName":"Martin Brown","firstName":"Martin","href":"http://med.stanford.edu/profiles/Martin_Brown","researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy."},{"lastName":"Straight","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","displayName":"Aaron Straight","firstName":"Aaron","href":"http://med.stanford.edu/profiles/Aaron_Straight","researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis."},{"lastName":"Zhang","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=35720&type=small&showNoImage","displayName":"Michael Zhang","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Zhang","researchInterest":""},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"McKay","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","displayName":"David B. McKay","firstName":"David","href":"http://med.stanford.edu/profiles/David_McKay","researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules."},{"lastName":"Yanofsky","clinicalFocus":[],"appointments":[{"appointment":"Professor Emeritus,Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Professor Emeritus,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6252&type=small&showNoImage","displayName":"Charles Yanofsky","firstName":"Charles","href":"http://med.stanford.edu/profiles/Charles_Yanofsky","researchInterest":""},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Associate Professor (By courtesy),Natural Sciences Cluster - Chemistry"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Chung","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Obstetrics & Gynecology"}],"primaryAppointment":"Basic Life Science Research Associate,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10387&type=small&showNoImage","displayName":"Young Min Chung","firstName":"Young Min","href":"http://med.stanford.edu/profiles/Young Min_Chung","researchInterest":""}]}