{"result":[{"researchInterest":"The goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8146&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Carla_Shatz","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Carla","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Carla Shatz","lastName":"Shatz"},{"researchInterest":"Our laboratory is studying synapse formation, stability and elimination at a variety of levels, e.g. from molecules to behavior.  A primary focus of the lab is to understanding the role that individual molecules play in the assembly and function of synaptic junctions.  In addition we evaluating a variety of potential treatments for cognitive impairment in Down syndrome in part by assessing the impact specific drugs on cognitive function in mouse models of Down syndrome.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3890&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Craig_Garner","appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"Craig","primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","displayName":"Craig C. Garner","lastName":"Garner"},{"researchInterest":"Experiments examine \r\n1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability\r\n2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors; \r\n3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.\r\n4. prophylaxis of postraumatic epilepsy\r\n5. Neocortical interneuronal function/modulation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4531&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Prince","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"David Prince","lastName":"Prince"},{"researchInterest":"For most areas of the mammalian brain, neurogenesis concludes at birth but there are exceptions to the rule. In rodents and humans, some areas of the brain continue to make new neurons throughout life. This process is mediated by neural stem cells and our research goals are to understand how stem cell activity is regulated and whether the nascent potential of resident stem cells can be harnessed for brain repair.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5930&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Theo_Palmer","appointments":[{"appointment":"Associate Professor,Neurosurgery"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Theo","primaryAppointment":"Associate Professor,Neurosurgery","displayName":"Theo Palmer","lastName":"Palmer"},{"researchInterest":"Development and regeneration of the visual system","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9622&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Andrew_Huberman","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Andrew","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Andrew D. Huberman","lastName":"Huberman"},{"researchInterest":"Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4239&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ben_Barres","appointments":[{"appointment":"Professor,Neurobiology"},{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Ophthalmology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor,Developmental Biology"}],"clinicalFocus":[],"firstName":"Ben","primaryAppointment":"Professor,Neurobiology","displayName":"Ben Barres","lastName":"Barres"},{"researchInterest":"Clinical interests include Alzheimer\u0092s disease and Huntington\u0092s disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7249&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Frank_Longo","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"clinicalFocus":[{"focus":"Neurology"},{"focus":"Alzheimer's Disease"},{"focus":"Huntington Disease"}],"firstName":"Frank","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"Frank M. Longo, M.D., Ph.D.","lastName":"Longo"},{"researchInterest":"We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4124&type=small&showNoImage","href":"http://med.stanford.edu/profiles/John_Huguenard","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"John","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"John Huguenard","lastName":"Huguenard"},{"researchInterest":"Most types of congenital and acquired hearing loss arise from damage to, or loss of hair cells, the sensory cells of the inner ear.  Our recent work has focused on generating inner ear cell types from stem cells and we are interested in signaling pathways that control hair cell and auditory neuron (re-)generation in vitro and in vivo.  In a second line of research, we are working on the identification and the molceular characterization of proteins that are important for hair cell function.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7084&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stefan_Heller","appointments":[{"appointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)"},{"appointment":"Associate Professor (By courtesy),Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Stefan","primaryAppointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)","displayName":"Stefan Heller","lastName":"Heller"},{"researchInterest":"Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8533&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Sudhof","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Psychiatry & Behavioral Science"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Thomas Sudhof","lastName":"Sudhof"},{"researchInterest":"Our group initially identified the hypocretins, two hypothalamic neuropeptides that have a key role in maintaining the states of vigilance. We also discovered cortistatin, a peptide that modulates cortical excitability. My lab uses molecular, pharmacological, anatomical and behavioral methods to identify new roles for these transmitters. We are also interested in the cellular and molecular mechanisms by which neuronal systems integrate homeostatic information and regulate complex behaviors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7308&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Luis_de Lecea","appointments":[{"appointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Luis","primaryAppointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center","displayName":"Luis de Lecea","lastName":"de Lecea"},{"researchInterest":"Dr. Helms' research interests center around craniofacial development and regenerative medicine.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6152&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jill_Helms","appointments":[{"appointment":"Associate Professor,Surgery - Plastic/Recon Surgery"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Jill","primaryAppointment":"Associate Professor,Surgery - Plastic/Recon Surgery","displayName":"Jill Helms","lastName":"Helms"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"We are studying how neural circuits are assembled during development, and how they contribute to sensory perception.  We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior.  We are primarily using Drosophila as a model organism for our studies.  Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6229&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Liqun_Luo","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor (By courtesy),Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Liqun","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Liqun Luo","lastName":"Luo"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8925&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Carson_Goddard","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Carson","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Carson Goddard","lastName":"Goddard"},{"researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matthew_Scott","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Matthew","primaryAppointment":"Professor,Developmental Biology","displayName":"Matthew Scott","lastName":"Scott"},{"researchInterest":"We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6244&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tim_Stearns","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Tim","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Tim Stearns","lastName":"Stearns"},{"researchInterest":"Craniofacial development and  patterning","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9172&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samantha_Brugmann","appointments":[{"appointment":"Postdoctoral Research fellow, Surgery"}],"clinicalFocus":[],"firstName":"Samantha","primaryAppointment":"Postdoctoral Research fellow, Surgery","displayName":"Samantha Brugmann","lastName":"Brugmann"},{"researchInterest":"I am interested in understanding the signaling pathways that regulate the development of specialized tight junctions in brain endothelial cells responsible for forming the blood-brain barrier. The identification of these signals is important for elucidating the mechanisms that regulate the entry of distinct compounds or drugs into the Central Nervous System (CNS) and the etiology of pathological CNS conditions associated with blood-brain barrier breakdown.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9742&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dritan_Agalliu","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Dritan","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Dritan Agalliu PhD","lastName":"Agalliu"},{"researchInterest":"The biochemistry and molecular genetics of growth and differentiation of nerve cells. The structure, biosynthesis and mechanism of action of nerve growth factor and other neurotrophins. Gene regulation in target organs and glial cells during nerve regeneration. The role of apolipoproteins and of the myelin protein PMP-22 during nerve degeneration and regeneration and in peripheral neuropathies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3996&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Eric_Shooter","appointments":[{"appointment":"Emeritus (Active) Professor,Neurobiology"}],"clinicalFocus":[],"firstName":"Eric","primaryAppointment":"Emeritus (Active) Professor,Neurobiology","displayName":"Eric Shooter","lastName":"Shooter"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"The main interest of my lab is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. Our approach includes recordings from multiple cells, calcium imaging, two-photon imaging and viral-based optogenetic methods to activate  cortical neurons as well as cortical afferents.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4343&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Shaul_Hestrin","appointments":[{"appointment":"Associate Professor,Comparative Medicine"}],"clinicalFocus":[],"firstName":"Shaul","primaryAppointment":"Associate Professor,Comparative Medicine","displayName":"Shaul Hestrin","lastName":"Hestrin"},{"researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Isabella_Graef","appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Isabella","primaryAppointment":"Assistant Professor,Pathology","displayName":"Isabella Graef","lastName":"Graef"},{"researchInterest":"My lab looks at the organization and function of central neural pathways that underlie directed manual behavior.  We are specifically interested in how these pathways adapt following injury, and use a combination of approaches in monkeys to identify mechanisms mediating neural reorganization and behavioral recovery.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5979&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Corinna_Darian-Smith","appointments":[{"appointment":"Associate Professor,Comparative Medicine"}],"clinicalFocus":[],"firstName":"Corinna","primaryAppointment":"Associate Professor,Comparative Medicine","displayName":"Corinna Darian-Smith","lastName":"Darian-Smith"},{"researchInterest":"My laboratory studies the mechanisms of cardiovascular development, particularly how the three major types of cardiac cells (endocardial, myocardial and epicardial cells) and neural crest cells interact with each other to generate heart tissues.  We are interested in the transcriptional and signaling events that coordinate their interactions and assembly into heart tissues.  The long-term goal is to understand the developmental mechanisms that control tissue formation and recapitulate the devel","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6387&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ching-Pin_Chang","appointments":[{"appointment":"Assistant Professor,Medicine - Cardiovascular Medicine"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Ching-Pin","primaryAppointment":"Assistant Professor,Medicine - Cardiovascular Medicine","displayName":"Ching-Pin Chang","lastName":"Chang"}]}