{"result":[{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Cohen","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Genetics","displayName":"Stanley N. Cohen, MD","lastName":"Cohen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4047&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jose_Montoya","appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Infectious Diseases"}],"clinicalFocus":[{"focus":"Infectious Disease"},{"focus":"Immunocompromised Host"},{"focus":"Toxoplasmosis"}],"firstName":"Jose","primaryAppointment":"Associate Professor - Med Center Line,Medicine - Infectious Diseases","displayName":"Jose G. Montoya","lastName":"Montoya"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9815&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gusti_Zeiner","appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Gusti","primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","displayName":"Gusti Zeiner","lastName":"Zeiner"},{"researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Berg","appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Emeritus (Active) Professor,Biochemistry","displayName":"Paul Berg","lastName":"Berg"},{"researchInterest":"Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models: Williams-Beuren syndrome, a heterozygous 1.6 megabase deletion; Rett syndrome, caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Mechanisms of genomic imprinting: Prader Willi syndrome","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4281&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Uta_Francke","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Pediatrics"}],"clinicalFocus":[{"focus":"Clinical Genetics"},{"focus":"Neurogenetics"}],"firstName":"Uta","primaryAppointment":"Professor,Genetics","displayName":"Uta Francke","lastName":"Francke"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15112&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Hunter_Fraser","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Hunter","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Hunter Fraser","lastName":"Fraser"},{"researchInterest":"Understanding genetic basis of cardiovascular function and disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Quertermous","appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","displayName":"Thomas Quertermous, MD","lastName":"Quertermous"},{"researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","href":"http://med.stanford.edu/profiles/John_Pringle","appointments":[{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"John","primaryAppointment":"Professor,Genetics","displayName":"John R. Pringle","lastName":"Pringle"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6220&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Marcus_Feldman","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Marcus","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Marcus Feldman","lastName":"Feldman"},{"researchInterest":"I refer you to my web page for detailed list of interests, projects and publications.  In addition to pressing the link here, you can search \"Russ Altman\" on http://www.google.com/","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4706&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Russ_Altman","appointments":[{"appointment":"Professor,Bioengineering"},{"appointment":"Professor,Medicine - Stanford Medical Informatics"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Russ","primaryAppointment":"Professor,Bioengineering","displayName":"Russ B. Altman","lastName":"Altman"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6234&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dmitri_Petrov","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Dmitri","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Dmitri Petrov","lastName":"Petrov"},{"researchInterest":"Our lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3861&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Upinder_Singh","appointments":[{"appointment":"Assistant Professor,Medicine - Infectious Diseases"},{"appointment":"Assistant Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Infectious Disease"},{"focus":"Infectious Diseases"}],"firstName":"Upinder","primaryAppointment":"Assistant Professor,Medicine - Infectious Diseases","displayName":"Upinder Singh","lastName":"Singh"},{"researchInterest":"Glycosylation in the secretory pathway.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7087&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jennifer_Kohler","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Jennifer","primaryAppointment":"Member,Bio-X","displayName":"Jennifer Kohler","lastName":"Kohler"},{"researchInterest":"The focus of my group is the application of bioinformatics to the collection and dissemination genetic, genomic and cellular  information. We abstracts the published results into our database, SGD. We explore the volumes of information that have been elucidated for the budding yeast S. cerevisiae.  My research is the applied use computers and databases: designing a resource to effectively provide biological information to the research community, and the development of the Gene Ontology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4249&type=small&showNoImage","href":"http://med.stanford.edu/profiles/JMichael_Cherry","appointments":[{"appointment":"Associate Professor (Research),Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"JMichael","primaryAppointment":"Associate Professor (Research),Genetics","displayName":"Mike Cherry","lastName":"Cherry"},{"researchInterest":"We study the function and molecular evolution of proteins and noncoding functional elements in the genome.  Please refer to our web site for more information:  http://mendel.stanford.edu/SidowLab/index.html","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4393&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Arend_Sidow","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Arend","primaryAppointment":"Associate Professor,Pathology","displayName":"Arend Sidow","lastName":"Sidow"},{"researchInterest":"Developing new mass spectrometry-based experimental and computational tools that advance the field of proteomics, and applying them to a variety of important biomedical paradigms, including cancer, aging, and stem cell biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12511&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joshua_Elias","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Joshua","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"Joshua Elias","lastName":"Elias"},{"researchInterest":"Our laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4458&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Sarnow","appointments":[{"appointment":"Professor,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Peter","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Peter Sarnow","lastName":"Sarnow"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6212&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Allan_Campbell","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Allan","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Allan Campbell","lastName":"Campbell"},{"researchInterest":"Dr. Falkow is no longer taking students or postdoctoral fellows in his laboratory.  \r\n\r\nPlease contact either Denise Monack (dmonack@stanford.edu) or Manuel Amieva (amieva@stanford.edu).","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4488&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Falkow","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Professor,Medicine"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Stanley Falkow","lastName":"Falkow"},{"researchInterest":"The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they are localized to distinct intracellular compartments in human cells, and how they serve as master regulators of all receptor trafficking events.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4087&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Suzanne_Pfeffer","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Suzanne","primaryAppointment":"Professor,Biochemistry","displayName":"Suzanne Pfeffer","lastName":"Pfeffer"},{"researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6213&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martha_Cyert","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Martha","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Martha Cyert","lastName":"Cyert"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6252&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Charles_Yanofsky","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Charles","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Charles Yanofsky","lastName":"Yanofsky"}]}