{"result":[{"lastName":"Tompkins","clinicalFocus":[{"focus":"Infectious Diseases"},{"focus":"Internal Medicine"},{"focus":"hospital epidemiology"}],"appointments":[{"appointment":"Professor,Medicine - Infectious Diseases"},{"appointment":"Professor,Microbiology & Immunology"}],"primaryAppointment":"Professor,Medicine - Infectious Diseases","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4603&type=small&showNoImage","displayName":"Lucy Tompkins","firstName":"Lucy","href":"http://med.stanford.edu/profiles/Lucy_Tompkins","researchInterest":"Molecular and cellular pathogenesis of Helicobacter infection. Molecular epidemiology, hospital epidemiology."},{"lastName":"Relman","clinicalFocus":[{"focus":"Infectious Disease"},{"focus":"Infectious Diseases"}],"appointments":[{"appointment":"Professor,Medicine - Infectious Diseases"},{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Infectious Diseases","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4005&type=small&showNoImage","displayName":"David A. Relman","firstName":"David","href":"http://med.stanford.edu/profiles/David_Relman","researchInterest":"My investigative program focuses on human-microbe interactions and human microbial ecology, and is divided into two research areas: 1) Ecology of human indigenous microbial communities; 2) Classification of humans and non-human primates with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns."},{"lastName":"Monack","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Microbiology & Immunology"}],"primaryAppointment":"Assistant Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8324&type=small&showNoImage","displayName":"Denise M. Monack","firstName":"Denise","href":"http://med.stanford.edu/profiles/Denise_Monack","researchInterest":"The primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis.  We use two model systems, Salmonella typhimurium and Francisella tularensis, to study the complex host-pathogen interactions.  Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response and how F. tularensis, a stealth invader, can cause a rapid, lethal infection."},{"lastName":"Amieva","clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"appointments":[{"appointment":"Assistant Professor,Pediatrics - Infectious Diseases"},{"appointment":"Assistant Professor,Microbiology & Immunology"}],"primaryAppointment":"Assistant Professor,Pediatrics - Infectious Diseases","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6150&type=small&showNoImage","displayName":"Manuel Amieva","firstName":"Manuel","href":"http://med.stanford.edu/profiles/Manuel_Amieva","researchInterest":"My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions.  We are also studying how variou"},{"lastName":"Cohen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","displayName":"Stanley N. Cohen, MD","firstName":"Stanley","href":"http://med.stanford.edu/profiles/Stanley_Cohen","researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis."},{"lastName":"Theriot","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Associate Professor,Microbiology & Immunology"}],"primaryAppointment":"Associate Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4432&type=small&showNoImage","displayName":"Julie Theriot","firstName":"Julie","href":"http://med.stanford.edu/profiles/Julie_Theriot","researchInterest":"We study the interactions between infectious bacteria and the human host cell actin cytoskeleton. Listeria monocytogenes and Shigella flexneri are unrelated food-borne bacterial pathogens that share a common mechanism of invasion and actin-dependent intercellular spread in epithelial cells. Our studies fall into three broad areas: the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis."},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Bouley","clinicalFocus":[],"appointments":[{"appointment":"Professor - Med Center Line,Comparative Medicine"},{"appointment":"Professor - Med Center Line (By courtesy),Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Comparative Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4428&type=small&showNoImage","displayName":"Donna M. Bouley","firstName":"Donna","href":"http://med.stanford.edu/profiles/Donna_Bouley","researchInterest":"Research interests: ocular pathology, host-pathogen interactions in infectious disease, infectious disease in frogs, phenotypic characterization of tg and ko mice, histopathology of minimally-invasive radiological ablation techniques (focused ultrasound, cryoablation)."},{"lastName":"Pride","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9162&type=small&showNoImage","displayName":"David Pride","firstName":"David","href":"http://med.stanford.edu/profiles/David_Pride","researchInterest":""},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Hershberg","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10299&type=small&showNoImage","displayName":"Ruth Hershberg","firstName":"Ruth","href":"http://med.stanford.edu/profiles/Ruth_Hershberg","researchInterest":"The aim of my research is to investigate the mechanisms, frequency, and consequences of the evolutionary shifts experienced by bacteria. Some more specific areas of research include:\r\n\r\n(1)  Quantifying shifts in the strength of purifying selection and understanding the consequences of such shifts\r\n \r\n(2)  Determining whether shifts in nucleotide content are driven by shifts in mutation or shifts in selection\r\n\r\n(3)  Establishing the mechanisms of shifts in codon usage bias"},{"lastName":"Matin","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4329&type=small&showNoImage","displayName":"AC Matin","firstName":"AC","href":"http://med.stanford.edu/profiles/AC_Matin","researchInterest":"1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity; 4. Bioremediation."},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","displayName":"Ronald Davis","firstName":"Ronald","href":"http://med.stanford.edu/profiles/Ronald_Davis","researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion."},{"lastName":"Covert","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Assistant Professor (By courtesy),Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7986&type=small&showNoImage","displayName":"Markus Covert","firstName":"Markus","href":"http://med.stanford.edu/profiles/Markus_Covert","researchInterest":"Our focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors."},{"lastName":"Parsonnet","clinicalFocus":[{"focus":"Infectious Disease"},{"focus":"Infectious Diseases"}],"appointments":[{"appointment":"Professor,Medicine - Infectious Diseases"},{"appointment":"Professor,Health Research & Policy"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Infectious Diseases","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4495&type=small&showNoImage","displayName":"Julie Parsonnet","firstName":"Julie","href":"http://med.stanford.edu/profiles/Julie_Parsonnet","researchInterest":"I am interested in the long-term consequences of chronic interactions between the human host and the microbial world.  Recently, we have focused most heavily on Helicobacter pylori, tuberculosis and helminth infections.  I also remain strongly interested in diarrheal diseases, particularly in the developing world, and in sanitation and hygiene."},{"lastName":"Butcher","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4498&type=small&showNoImage","displayName":"Eugene Butcher","firstName":"Eugene","href":"http://med.stanford.edu/profiles/Eugene_Butcher","researchInterest":"Our interests include: \r\n1) The physiology and significance of lymphocyte homing in local and systemic immunity; \r\n2) biochemical and genetic studies of molecules that direct leukocyte recruitment; \r\n3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; \r\n4) vascular differentiation in normal and pathologic inflammatory states; \r\n5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs."},{"lastName":"Sherlock","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5864&type=small&showNoImage","displayName":"Gavin Sherlock","firstName":"Gavin","href":"http://med.stanford.edu/profiles/Gavin_Sherlock","researchInterest":"Evolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species; genome database for Candida albicans; genome database for Aspergilli; the Stanford Microarray Database; The Tuberculosis Database; bioinformatics tools for analysing expression data."},{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."},{"lastName":"Contag","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pediatrics - Neonatology"},{"appointment":"Associate Professor,Microbiology & Immunology"},{"appointment":"Associate Professor (By courtesy),Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pediatrics - Neonatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4036&type=small&showNoImage","displayName":"Christopher H. Contag","firstName":"Christopher","href":"http://med.stanford.edu/profiles/Christopher_Contag","researchInterest":"We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in \"a vacuum\" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","displayName":"Leonard Herzenberg","firstName":"Leonard","href":"http://med.stanford.edu/profiles/Leonard_Herzenberg","researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC)."},{"lastName":"Phillips","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pediatrics"}],"primaryAppointment":"Postdoctoral Research fellow, Pediatrics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9437&type=small&showNoImage","displayName":"Neil Phillips","firstName":"Neil","href":"http://med.stanford.edu/profiles/Neil_Phillips","researchInterest":""},{"lastName":"Shen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"primaryAppointment":"Postdoctoral Research fellow, Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9376&type=small&showNoImage","displayName":"Aimee Shen","firstName":"Aimee","href":"http://med.stanford.edu/profiles/Aimee_Shen","researchInterest":""},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","displayName":"Leonore A. Herzenberg","firstName":"Leonore","href":"http://med.stanford.edu/profiles/Leonore_Herzenberg","researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays."},{"lastName":"Diehn","clinicalFocus":[],"appointments":[{"appointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy"}],"primaryAppointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9248&type=small&showNoImage","displayName":"Maximilian Diehn, M.D., Ph.D.","firstName":"Maximilian","href":"http://med.stanford.edu/profiles/Maximilian_Diehn","researchInterest":"My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells."}]}