{"result":[{"researchInterest":"We have recently cloned a novel NK cell receptor which is likely involved in the activation of NK cells and are characterizing the expression and effector functions of this receptor in the context of transplantation. In related studies the role of NK cells in alloreactivity is being examined. Pathways of apoptosis, especially the pro-apoptotic molecule BID, is being studied in hepatocytes and allogeneic liver grafts","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4475&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sheri_Krams","appointments":[{"appointment":"Associate Professor (Research),Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Sheri","primaryAppointment":"Associate Professor (Research),Surgery - Multi-Organ Transplantation","displayName":"Sheri Krams","lastName":"Krams"},{"researchInterest":"1)Organ presevation with the use of anti-freeze proteins.\r\n2)Induction of immunotolerance\r\n3)Role of FOX-P3 in tolerant recipients\r\n4)Molecular changes induced by EBV infection in the transplant recipient","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4207&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Carlos_Esquivel","appointments":[{"appointment":"Professor - Med Center Line,Surgery - Multi-Organ Transplantation"}],"clinicalFocus":[{"focus":"General Surgery"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Liver Transplantation"},{"focus":"Surgical Critical Care"}],"firstName":"Carlos","primaryAppointment":"Professor - Med Center Line,Surgery - Multi-Organ Transplantation","displayName":"Carlos O. Esquivel","lastName":"Esquivel"},{"researchInterest":"I work as a diagnostic surgical pathologist doing tissue and cDNA microarray-based translational research in renal neoplasia and medical renal disease. Subspecialty areas of clinical interest include diagnostic immunohistochemistry, renal, hepatic and transplant pathology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4038&type=small&showNoImage","href":"http://med.stanford.edu/profiles/John_Higgins","appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"John","primaryAppointment":"Associate Professor - Med Center Line,Pathology","displayName":"John Higgins","lastName":"Higgins"},{"researchInterest":"Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4490&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Edgar_Engleman","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"firstName":"Edgar","primaryAppointment":"Professor,Pathology","displayName":"Edgar Engleman","lastName":"Engleman"},{"researchInterest":"Gastroenterology, biliary motility, hormonal regulation, embryology, gastrointestinal tract, clinical management of pediatric liver transplant recipients.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4210&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kenneth_Cox","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Gastroenterology"}],"clinicalFocus":[{"focus":"Gastroenterology/Nutrition/Hepatology, Pediatric"},{"focus":"Pediatric Gastroenterology"}],"firstName":"Kenneth","primaryAppointment":"Professor - Med Center Line,Pediatrics - Gastroenterology","displayName":"Kenneth L. Cox","lastName":"Cox"},{"researchInterest":"Through a 3 pronged comprehensive program: translational and clinical research, early detection and treatment, and promoting education, awareness and immunization, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Our current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4206&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samuel_So","appointments":[{"appointment":"Professor - Med Center Line,Surgery - General Surgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Gastrointestinal Cancers"},{"focus":"Gastrointestinal Cancers - Surgical Oncology"},{"focus":"General Surgery"},{"focus":"Liver Cancer"},{"focus":"Liver Cancer - Surgery"}],"firstName":"Samuel","primaryAppointment":"Professor - Med Center Line,Surgery - General Surgery","displayName":"Samuel So","lastName":"So"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function. Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Lewis","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"firstName":"David","primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","displayName":"David B. Lewis","lastName":"Lewis"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3884&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Clark_Bonham","appointments":[{"appointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"General Surgery"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Liver Transplantation"}],"firstName":"Clark","primaryAppointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation","displayName":"Clark Bonham","lastName":"Bonham"},{"researchInterest":"Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4152&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samuel_Strober","appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"firstName":"Samuel","primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","displayName":"Samuel Strober","lastName":"Strober"},{"researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome. Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","href":"http://med.stanford.edu/profiles/C_Fathman","appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"firstName":"C","primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","displayName":"C. Garrison Fathman","lastName":"Fathman"},{"researchInterest":"Studies on apoptotic cell death in vivo using the H MRS phenomenon.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4065&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Francis_Blankenberg","appointments":[{"appointment":"Associate Professor,Radiology"},{"appointment":"Associate Professor (By courtesy),Pediatrics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Diagnostic Radiology"},{"focus":"Radiology"},{"focus":"Radiology, Pediatric"}],"firstName":"Francis","primaryAppointment":"Associate Professor,Radiology","displayName":"Francis Blankenberg","lastName":"Blankenberg"},{"researchInterest":"My research interests focus on the identification and characterization of markers of diagnostic and prognostic importance in hematolymphoid neoplasia.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5929&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yasodha_Natkunam","appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematopathology"},{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Yasodha","primaryAppointment":"Associate Professor - Med Center Line,Pathology","displayName":"Yasodha Natkunam, M.D., Ph.D","lastName":"Natkunam"},{"researchInterest":"Gastroenterology, gastointestinal motility, clinical management of pediatric liver transplant recipients.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4209&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Berquist","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Gastroenterology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Pediatric Gastroenterology"},{"focus":"Ped Gastroenterology"}],"firstName":"William","primaryAppointment":"Professor - Med Center Line,Pediatrics - Gastroenterology","displayName":"William Berquist","lastName":"Berquist"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3809&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stephan_Busque","appointments":[{"appointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation"}],"clinicalFocus":[{"focus":"General Surgery"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Liver Transplantation"}],"firstName":"Stephan","primaryAppointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation","displayName":"Stephan Busque","lastName":"Busque"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10139&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Alexander_Filatenkov","appointments":[{"appointment":"Postdoctoral Research fellow, School of Medicine"}],"clinicalFocus":[],"firstName":"Alexander","primaryAppointment":"Postdoctoral Research fellow, School of Medicine","displayName":"Alexander Filatenkov","lastName":"Filatenkov"},{"researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC).","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Leonard_Herzenberg","appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Leonard","primaryAppointment":"Emeritus (Active) Professor,Genetics","displayName":"Leonard Herzenberg","lastName":"Herzenberg"},{"researchInterest":"Our interests include: \r\n1) The physiology and significance of lymphocyte homing in local and systemic immunity; \r\n2) biochemical and genetic studies of molecules that direct leukocyte recruitment; \r\n3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; \r\n4) vascular differentiation in normal and pathologic inflammatory states; \r\n5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4498&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Eugene_Butcher","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Eugene","primaryAppointment":"Professor,Pathology","displayName":"Eugene Butcher","lastName":"Butcher"},{"researchInterest":"Stem Cell Therapy for Myocardial Restoration, Cardiopulmonary Transplantation, Cardiac Allograft Vasculopathy, Automated Anastomotic Devices, Genetics and Mechanisms of Congestive Heart Failure","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4247&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Robbins","appointments":[{"appointment":"Professor,Cardiothoracic Surgery - Adult Cardiac Surgery"},{"appointment":"Professor (By courtesy),Surgery"}],"clinicalFocus":[{"focus":"Heart and Lung Transplantation"},{"focus":"Cardiothoracic Surgery"},{"focus":"Thoracic Surgery"}],"firstName":"Robert","primaryAppointment":"Professor,Cardiothoracic Surgery - Adult Cardiac Surgery","displayName":"Robert C. Robbins, M. D.","lastName":"Robbins"},{"researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Leonore_Herzenberg","appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Leonore","primaryAppointment":"Professor (Research),Genetics","displayName":"Leonore A. Herzenberg","lastName":"Herzenberg"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8537&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Wei","appointments":[{"appointment":"Instructor,Pediatrics - Hematology/Oncology"},{"appointment":"Postdoctoral Medical fellow, Pediatrics"}],"clinicalFocus":[{"focus":"Hematology/Oncology/Stem Cell Transplant, Pediatric"},{"focus":"Pediatric Hematology-Oncology"}],"firstName":"Michael","primaryAppointment":"Instructor,Pediatrics - Hematology/Oncology","displayName":"Michael Wei, MD, PhD","lastName":"Wei"},{"researchInterest":"Immunologic mechanism of rejection in humans and animal, models of organ transplantation; histological definition of clinical pathology studies of various renal disorders.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4113&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Sibley","appointments":[{"appointment":"Professor,Pathology"}],"clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Richard","primaryAppointment":"Professor,Pathology","displayName":"Richard Sibley","lastName":"Sibley"},{"researchInterest":"Molecular and immunological basis of transplant dysfunction and acceptance. cDNA microarray analysis of transplant rejection defined a novel role for B cells in poor prognostic categories of transplant rejection. Also identified a tolerance footprint of < 50 genes that can diagnose tolerance in peripheral blood. Pioneered the first steroid free trial in pediatric kidney transplantation, (NIH-multicenter study). Runs the Bay Area Cystinosis and Stanford Pediatric Renal Transplant clinics.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4430&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Minnie_Sarwal","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Nephrology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Nephrology (Kidney), Pediatric"},{"focus":"Pediatric Nephrology"}],"firstName":"Minnie","primaryAppointment":"Professor - Med Center Line,Pediatrics - Nephrology","displayName":"Minnie Sarwal","lastName":"Sarwal"},{"researchInterest":"Understanding the biology of cancer-T cell interactions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4564&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Lee","appointments":[{"appointment":"Associate Professor,Medicine - Hematology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematology"},{"focus":"Leukemia - Hematology"}],"firstName":"Peter","primaryAppointment":"Associate Professor,Medicine - Hematology","displayName":"Peter P. Lee","lastName":"Lee"},{"researchInterest":"Kari Nadeau, MD, PhD, Allergy, Immunology and Asthma\r\nOur research interests in the laboratory focus on the role of human T cells,\r\nspecifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the\r\nmechanisms of action of regulatory T cell suppressive function. We study\r\nhow pollution, such as diesel exhause, disrupt Treg suppressive function and how\r\nchemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7485&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kari_Nadeau","appointments":[{"appointment":"Assistant Professor - Med Center Line,Pediatrics - Allergy & Clinical Immunology"},{"appointment":"Assistant Professor - Med Center Line (By courtesy),Otolaryngology (Head and Neck Surgery)"}],"clinicalFocus":[{"focus":"Allergy and Immunology"},{"focus":"Pediatric Allergy/Immun"}],"firstName":"Kari","primaryAppointment":"Assistant Professor - Med Center Line,Pediatrics - Allergy & Clinical Immunology","displayName":"Kari Nadeau, MD, PhD","lastName":"Nadeau"}]}