{"result":[{"researchInterest":"The Puglisi group investigates the role of RNA in cellular processes and disease.  We investigate dynamics using single-molecule approaches.  Our goal is a unified picture of structure, dynamics and function.  We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections.  A long-term goal is to target processes involving RNA with novel therapeutic strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4431&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joseph_Puglisi","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Joseph","primaryAppointment":"Professor,Structural Biology","displayName":"Joseph (Jody) Puglisi","lastName":"Puglisi"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. I seek to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. I use single molecule tracking and manipulation techniques to observe and perturb substeps in the mechanochemical cycles of individual motors. My main focus is torque generation by DNA-associated ATPases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10234&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Florian_Oberstrass","appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"clinicalFocus":[],"firstName":"Florian","primaryAppointment":"Postdoctoral Research fellow, Bioengineering","displayName":"Florian Oberstrass","lastName":"Oberstrass"},{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"The biochemistry of RNA-dependent RNA polymerase function, the cell biology of the membrane rearrangements induced by positive-strand RNA virus infection of human cells, and the genetics of RNA viruses, which, with their high error rates, live at the brink of error catastrophe, are investigated in the Kirkegaard laboratory.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4459&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Karla_Kirkegaard","appointments":[{"appointment":"Professor,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Karla","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Karla Kirkegaard","lastName":"Kirkegaard"},{"researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Berg","appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Emeritus (Active) Professor,Biochemistry","displayName":"Paul Berg","lastName":"Berg"},{"researchInterest":"Viral infections and subsequent host response depend on multiple RNA-protein interaction. My research focuses on the structural and functional characterization of RNA-protein complexes involved in viral infection. Current research aims to understand how the Human Immunodeficiency Virus (HIV) initiates its replication upon host infection. We use NMR spectroscopy and x-ray crystallography to study the structure of the initiation complex, formed by a host tRNA and HIV genomic RNA, coupled with bio","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10456&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Elisabetta_Puglisi","appointments":[{"appointment":"Assistant Professor (Research),Structural Biology"}],"clinicalFocus":[],"firstName":"Elisabetta","primaryAppointment":"Assistant Professor (Research),Structural Biology","displayName":"Elisabetta Viani Puglisi","lastName":"Puglisi"},{"researchInterest":"Research focusses on one of the human herpesviruses: cytomegalovirus (CMV). This virus is a major medical problem in immunocompromised individuals. The virus is very large, carrying over 200 genes. We have characterized functions involved in viral growth (regulation of gene expression, replication, genome packaging) and pathogenesis (tissue tropism, latency). Molecular genetic and biochemical approaches have been employed to dissect these functions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4146&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Edward_Mocarski","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Edward","primaryAppointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology","displayName":"Edward Mocarski","lastName":"Mocarski"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9664&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Chih_Liu","appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"clinicalFocus":[],"firstName":"Chih","primaryAppointment":"Postdoctoral Research fellow, Medicine","displayName":"Chih Long Liu","lastName":"Liu"},{"researchInterest":"We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4308&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roger_Kornberg","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Roger","primaryAppointment":"Professor,Structural Biology","displayName":"Roger Kornberg","lastName":"Kornberg"},{"researchInterest":"Research in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7764&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joanna_Wysocka","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Assistant Professor,Developmental Biology"}],"clinicalFocus":[],"firstName":"Joanna","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"Joanna Wysocka","lastName":"Wysocka"},{"researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Cohen","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Genetics","displayName":"Stanley N. Cohen, MD","lastName":"Cohen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9897&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Shuo_Gu","appointments":[{"appointment":"Postdoctoral Research fellow, Pediatrics"}],"clinicalFocus":[],"firstName":"Shuo","primaryAppointment":"Postdoctoral Research fellow, Pediatrics","displayName":"Shuo Gu","lastName":"Gu"},{"researchInterest":"The long term goal  of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether  reengineering chaperone networks can provide therapeutic strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6222&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Judith_Frydman","appointments":[{"appointment":"Associate Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Judith","primaryAppointment":"Associate Professor,Biology (School of Humanities and Sciences)","displayName":"Judith Frydman","lastName":"Frydman"},{"researchInterest":"Molecular mechanisms of pathogenesis; determinants of protective immunity; host range and tissue tropism in liver and GI tract pathogenic viruses and studies of vaccines in people.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3791&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Harry_Greenberg","appointments":[{"appointment":"Professor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Harry","primaryAppointment":"Professor,Medicine - Gastroenterology & Hepatology","displayName":"Harry B Greenberg","lastName":"Greenberg"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yahli_Lorch","appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"clinicalFocus":[],"firstName":"Yahli","primaryAppointment":"Associate Professor (Research),Structural Biology","displayName":"Yahli Lorch","lastName":"Lorch"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bruce_Baker","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Bruce","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Bruce Baker","lastName":"Baker"},{"researchInterest":"Mark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics.  Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4409&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Kay","appointments":[{"appointment":"Professor,Pediatrics - Human Gene Therapy"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Pediatrics - Human Gene Therapy","displayName":"Mark A. Kay, M.D., Ph.D.","lastName":"Kay"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9360&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ryan_Tyler","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Ryan","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"Ryan Tyler","lastName":"Tyler"},{"researchInterest":"We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease.  Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes.  We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6423&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Or_Gozani","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Or","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Or Gozani","lastName":"Gozani"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Linda_Boxer","appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"firstName":"Linda","primaryAppointment":"Professor,Medicine - Hematology","displayName":"Linda Boxer","lastName":"Boxer"},{"researchInterest":"Tobin is a Senior Research Scholar in the Program for Genomics, Ethics, and Society at the Stanford Center for Biomedical Ethics. She obtained her Ph.D. in Developmental Biology from the University of Washington and did postdoctoral research in Genetics at the University of California, Berkeley and in Biochemistry at the University of California, San Francisco. She became a faculty member at the University of Oklahoma College of Medicine in 1983, where she established her independent research l","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6945&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sara_Tobin","appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Sr Research Scholar (PI Waiver),Center for Biomedical Ethics"}],"clinicalFocus":[],"firstName":"Sara","primaryAppointment":"Member,Cancer Center","displayName":"Sara L. (Sally) Tobin","lastName":"Tobin"},{"researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gilbert_Chu","appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Oncology"}],"firstName":"Gilbert","primaryAppointment":"Professor,Medicine - Oncology","displayName":"Gilbert Chu","lastName":"Chu"}]}