{"result":[{"researchInterest":"Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Levitt","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Professor,Structural Biology","displayName":"Michael Levitt","lastName":"Levitt"},{"researchInterest":"Rhiju Das strives to predict how sequence codes for structure in proteins, nucleic acids, and heteropolymers whose folds have yet to be explored. The Das group uses new computational and experimental tools to tackle the de novo modeling of protein and RNA folds, the high-throughput structure mapping of riboswitches and random RNAs, and the design of self-knotting and self-crystallizing nucleic acids.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10421&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Rhiju_Das","appointments":[{"appointment":"Assistant Professor,Biochemistry"}],"clinicalFocus":[],"firstName":"Rhiju","primaryAppointment":"Assistant Professor,Biochemistry","displayName":"Rhiju Das","lastName":"Das"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8633&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jonathan_Lassila","appointments":[{"appointment":"Postdoctoral Research fellow, Biochemistry"}],"clinicalFocus":[],"firstName":"Jonathan","primaryAppointment":"Postdoctoral Research fellow, Biochemistry","displayName":"Jonathan Lassila","lastName":"Lassila"},{"researchInterest":"I closed my laboratory when I retired in 1998.  I continue to do research, chiefly in collaboration with Franc Avbelj, on problems of protein folding energetics, especially peptide backbone solvation,  and to write reviews.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6816&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Baldwin","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"clinicalFocus":[],"firstName":"Robert","primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","displayName":"Robert Baldwin","lastName":"Baldwin"},{"researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_McKay","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","displayName":"David B. McKay","lastName":"McKay"},{"researchInterest":"I refer you to my web page for detailed list of interests, projects and publications.  In addition to pressing the link here, you can search \"Russ Altman\" on http://www.google.com/","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4706&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Russ_Altman","appointments":[{"appointment":"Professor,Bioengineering"},{"appointment":"Professor,Medicine - Stanford Medical Informatics"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Russ","primaryAppointment":"Professor,Bioengineering","displayName":"Russ B. Altman","lastName":"Altman"},{"researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Weis","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"William","primaryAppointment":"Professor,Structural Biology","displayName":"William Weis","lastName":"Weis"},{"researchInterest":"Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology.  We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4370&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Chris_Garcia","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Chris","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Chris Garcia","lastName":"Garcia"},{"researchInterest":"Structure, dynamics and function of proteins involved in transport and regulatory processes; high resolution nuclear magnetic resonance studies of conformational transitions and protein folding; study of the mechanism of action of the trp-repressor, ankyrin-domain proteins and the development of programs to calculate protein solution structure","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4190&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Oleg_Jardetzky","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"clinicalFocus":[],"firstName":"Oleg","primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","displayName":"Oleg Jardetzky","lastName":"Jardetzky"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10270&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Minary","appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"clinicalFocus":[],"firstName":"Peter","primaryAppointment":"Postdoctoral Research fellow, Structural Biology","displayName":"Peter Minary","lastName":"Minary"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10008&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stephen_Kaiser","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Stephen","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"Stephen Kaiser","lastName":"Kaiser"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8953&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jennifer_Ptacek","appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Jennifer","primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","displayName":"Jennifer B. Ptacek","lastName":"Ptacek"},{"researchInterest":"The Puglisi group investigates the role of RNA in cellular processes and disease.  We investigate dynamics using single-molecule approaches.  Our goal is a unified picture of structure, dynamics and function.  We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections.  A long-term goal is to target processes involving RNA with novel therapeutic strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4431&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joseph_Puglisi","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Joseph","primaryAppointment":"Professor,Structural Biology","displayName":"Joseph (Jody) Puglisi","lastName":"Puglisi"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8081&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Edward_Solomon","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Edward","primaryAppointment":"Member,Bio-X","displayName":"Edward Solomon","lastName":"Solomon"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8050&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Steven_Boxer","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Steven","primaryAppointment":"Member,Bio-X","displayName":"Steven Boxer","lastName":"Boxer"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9027&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tianyun_Liu","appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"clinicalFocus":[],"firstName":"Tianyun","primaryAppointment":"Postdoctoral Research fellow, Genetics","displayName":"Tianyun Liu","lastName":"Liu"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9775&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Pablo_Jadzinsky","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Pablo","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Pablo Jadzinsky","lastName":"Jadzinsky"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9216&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Broering","appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Postdoctoral Research fellow, Bioengineering","displayName":"James Broering","lastName":"Broering"},{"researchInterest":"Molecular Bioengineering, Protein Biochemistry and Biotechnology, Cell and Tissue Engineering, Molecular Imaging","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6393&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jennifer_Cochran","appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jennifer","primaryAppointment":"Assistant Professor,Bioengineering","displayName":"Jennifer R. Cochran","lastName":"Cochran"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6252&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Charles_Yanofsky","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Charles","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Charles Yanofsky","lastName":"Yanofsky"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12553&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Valeria_Vasquez","appointments":[{"appointment":"Postdoctoral Research fellow, Mechanical Engineering"}],"clinicalFocus":[],"firstName":"Valeria","primaryAppointment":"Postdoctoral Research fellow, Mechanical Engineering","displayName":"Valeria Vasquez","lastName":"Vasquez"},{"researchInterest":"Developing new mass spectrometry-based experimental and computational tools that advance the field of proteomics, and applying them to a variety of important biomedical paradigms, including cancer, aging, and stem cell biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12511&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joshua_Elias","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Joshua","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"Joshua Elias","lastName":"Elias"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9132&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Erik_Miller","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Erik","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"Erik Miller","lastName":"Miller"},{"researchInterest":"The long term goal  of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether  reengineering chaperone networks can provide therapeutic strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6222&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Judith_Frydman","appointments":[{"appointment":"Associate Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Judith","primaryAppointment":"Associate Professor,Biology (School of Humanities and Sciences)","displayName":"Judith Frydman","lastName":"Frydman"},{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"}]}