{"result":[{"researchInterest":"A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4316&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Lucille_Shapiro","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Senior Fellow (By courtesy),Spogli Inst for Intrntl Studies"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Lucille","primaryAppointment":"Professor,Developmental Biology","displayName":"Lucy Shapiro","lastName":"Shapiro"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6212&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Allan_Campbell","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Allan","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Allan Campbell","lastName":"Campbell"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9747&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Erin_Goley","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Erin","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Erin Goley","lastName":"Goley"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8857&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Joseph_Lesley","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Joseph","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Joseph Lesley","lastName":"Lesley"},{"researchInterest":"Physical chemistry/chemical physics: single-molecule imaging and spectroscopy in condensed phases; superresolution imaging of biomolecules in cells; fluorophores for cellular imaging; single-molecule biophysics; nanophotonics to produce enhanced optical fields; trapping single molecules in solution","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8121&type=small&showNoImage","href":"http://med.stanford.edu/profiles/W_Moerner","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"W","primaryAppointment":"Member,Bio-X","displayName":"W. E. Moerner","lastName":"Moerner"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9464&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Beat_Christen","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Beat","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Beat Christen","lastName":"Christen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10113&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Grant_Bowman","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Grant","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Grant Bowman","lastName":"Bowman"},{"researchInterest":"Our lab is interested in how bacteria monitor and coordinate cell cycle events. We are focused on identifying and characterizing signal transduction pathways used by the bacterium Bacillus subtilis to regulate cell cycle progression and development in response to chromosome status. Our goal is to understand how these pathways work mechanistically and how they contribute to normal growth, development, and genome stability.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6211&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bill_Burkholder","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Bill","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Bill Burkholder","lastName":"Burkholder"},{"researchInterest":"The aim of my research is to investigate the mechanisms, frequency, and consequences of the evolutionary shifts experienced by bacteria. Some more specific areas of research include:\r\n\r\n(1)  Quantifying shifts in the strength of purifying selection and understanding the consequences of such shifts\r\n \r\n(2)  Determining whether shifts in nucleotide content are driven by shifts in mutation or shifts in selection\r\n\r\n(3)  Establishing the mechanisms of shifts in codon usage bias","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10299&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ruth_Hershberg","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Ruth","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"Ruth Hershberg","lastName":"Hershberg"},{"researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Cohen","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Genetics","displayName":"Stanley N. Cohen, MD","lastName":"Cohen"},{"researchInterest":"Our focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7986&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Markus_Covert","appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Assistant Professor (By courtesy),Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Markus","primaryAppointment":"Assistant Professor,Bioengineering","displayName":"Markus Covert","lastName":"Covert"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6252&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Charles_Yanofsky","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Charles","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Charles Yanofsky","lastName":"Yanofsky"},{"researchInterest":"1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity; 4. Bioremediation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4329&type=small&showNoImage","href":"http://med.stanford.edu/profiles/AC_Matin","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"AC","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"AC Matin","lastName":"Matin"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"Dr. Falkow is no longer taking students or postdoctoral fellows in his laboratory.  \r\n\r\nPlease contact either Denise Monack (dmonack@stanford.edu) or Manuel Amieva (amieva@stanford.edu).","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4488&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Falkow","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Professor,Medicine"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Stanley Falkow","lastName":"Falkow"},{"researchInterest":"Single cell gene expression, cancer stem cells, biological networks, systems biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10137&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tomer_Kalisky","appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"clinicalFocus":[],"firstName":"Tomer","primaryAppointment":"Postdoctoral Research fellow, Bioengineering","displayName":"Tomer Kalisky","lastName":"Kalisky"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6209&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Steven_Block","appointments":[{"appointment":"Professor,Applied Physics"},{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Senior Fellow (By courtesy),Spogli Inst for Intrntl Studies"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Steven","primaryAppointment":"Professor,Applied Physics","displayName":"Steven M. Block","lastName":"Block"},{"researchInterest":"We study the interactions between infectious bacteria and the human host cell actin cytoskeleton. Listeria monocytogenes and Shigella flexneri are unrelated food-borne bacterial pathogens that share a common mechanism of invasion and actin-dependent intercellular spread in epithelial cells. Our studies fall into three broad areas: the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4432&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Julie_Theriot","appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Associate Professor,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Julie","primaryAppointment":"Associate Professor,Biochemistry","displayName":"Julie Theriot","lastName":"Theriot"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9443&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Elhanan_Borenstein","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Elhanan","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"Elhanan Borenstein","lastName":"Borenstein"},{"researchInterest":"My lab is developing novel vectors and strategies for gene therapy.  We are focused on creating and using plasmid DNA vectors that integrate into the genome in a site-specific manner.  We are developing innovative gene therapies for a variety of tissues and diseases, including approaches involving stem cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4100&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michele_Calos","appointments":[{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"Michele","primaryAppointment":"Professor,Genetics","displayName":"Michele Calos","lastName":"Calos"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9162&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Pride","appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Postdoctoral Medical fellow, Medicine","displayName":"David Pride","lastName":"Pride"},{"researchInterest":"The photochemistry and radiation chemistry of DNA, the genetic control and biochemical bases of the multiple pathways of DNA repair, and the roles of DNA repair processes in radiation and spontaneous mutagenesis. Over 190 papers have been published on these and related topics.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7014&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kendric_Smith","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Radiation Oncology"}],"clinicalFocus":[],"firstName":"Kendric","primaryAppointment":"Emeritus Faculty, Acad Council,Radiation Oncology","displayName":"Kendric C. Smith","lastName":"Smith"},{"researchInterest":"Translational bioinformatics has been defined as the development of analytic\r\nmethods to help transform increasingly voluminous genomic and biological data into diagnostics and therapeutics for the clinician.  The long-term research goal of the Butte Lab is to develop translational bioinformatics methods to reason over many available genome-scale measurement and experimental modalities, and apply these methods to study complex disorders in genomic medicine, especially obesity and diabetes.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6603&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Atul_Butte","appointments":[{"appointment":"Assistant Professor,Pediatrics - Cancer Biology"},{"appointment":"Assistant Professor,Medicine"},{"appointment":"Assistant Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Atul","primaryAppointment":"Assistant Professor,Pediatrics - Cancer Biology","displayName":"Atul Butte","lastName":"Butte"},{"researchInterest":"Evolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species; genome database for Candida albicans; genome database for Aspergilli; the Stanford Microarray Database; The Tuberculosis Database; bioinformatics tools for analysing expression data.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5864&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gavin_Sherlock","appointments":[{"appointment":"Assistant Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gavin","primaryAppointment":"Assistant Professor (Research),Genetics","displayName":"Gavin Sherlock","lastName":"Sherlock"},{"researchInterest":"I am interested in the genetics of autism spectrum and other developmental disorders.   In collaboration with the laboratories of Dr. Ricardo Dolmetsch and Joachim Hallmayer I am working to develop induced pluripotent stem cell (iPSC) models of genetic disorders associated with autism and developmental disability.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8523&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jonathan_Bernstein","appointments":[{"appointment":"Clinical Assistant Professor,Pediatrics - Genetics"}],"clinicalFocus":[{"focus":"Autism"},{"focus":"Developmental Disorders"},{"focus":"Craniofacial Abnormalities"},{"focus":"Craniosynostosis"},{"focus":"Cleft Lip"},{"focus":"Cleft Palate"},{"focus":"General Pediatrics"}],"firstName":"Jonathan","primaryAppointment":"Clinical Assistant Professor,Pediatrics - Genetics","displayName":"Jon Bernstein","lastName":"Bernstein"}]}