{"result":[{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yahli_Lorch","appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"clinicalFocus":[],"firstName":"Yahli","primaryAppointment":"Associate Professor (Research),Structural Biology","displayName":"Yahli Lorch","lastName":"Lorch"},{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9775&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Pablo_Jadzinsky","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Pablo","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Pablo Jadzinsky","lastName":"Jadzinsky"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9607&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Karl-Magnus_Larsson","appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"clinicalFocus":[],"firstName":"Karl-Magnus","primaryAppointment":"Postdoctoral Research fellow, Structural Biology","displayName":"Karl-Magnus Larsson","lastName":"Larsson"},{"researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_McKay","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","displayName":"David B. McKay","lastName":"McKay"},{"researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","href":"http://med.stanford.edu/profiles/John_Pringle","appointments":[{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"John","primaryAppointment":"Professor,Genetics","displayName":"John R. Pringle","lastName":"Pringle"},{"researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Berg","appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Emeritus (Active) Professor,Biochemistry","displayName":"Paul Berg","lastName":"Berg"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9664&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Chih_Liu","appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"clinicalFocus":[],"firstName":"Chih","primaryAppointment":"Postdoctoral Research fellow, Medicine","displayName":"Chih Long Liu","lastName":"Liu"},{"researchInterest":"Hanawalt has been a productive researcher in the field of DNA repair since his pioneering discovery of repair replication in E. coli in 1963. He also first demonstrated repair replication in mycoplasmata and in a eukaryote and he has developed a number of important experimental approaches for studying repair, beginning with the BrdUrd density labeling method for resolving semiconservatively replicated DNA from parental DNA containing repair patches. Hanawalt\u0092s approach was used to validate the ","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5957&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Philip_Hanawalt","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Philip","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Philip Hanawalt","lastName":"Hanawalt"},{"researchInterest":"We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease.  Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes.  We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6423&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Or_Gozani","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Or","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Or Gozani","lastName":"Gozani"},{"researchInterest":"Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Levitt","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Professor,Structural Biology","displayName":"Michael Levitt","lastName":"Levitt"},{"researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gilbert_Chu","appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Oncology"}],"firstName":"Gilbert","primaryAppointment":"Professor,Medicine - Oncology","displayName":"Gilbert Chu","lastName":"Chu"},{"researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ashby_Morrison","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ashby","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Ashby Morrison","lastName":"Morrison"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10605&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sean_Collins","appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"clinicalFocus":[],"firstName":"Sean","primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","displayName":"Sean Collins","lastName":"Collins"},{"researchInterest":"Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4433&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Pehr_Harbury","appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Pehr","primaryAppointment":"Associate Professor,Biochemistry","displayName":"Pehr Harbury","lastName":"Harbury"},{"researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Karlene_Cimprich","appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Karlene","primaryAppointment":"Associate Professor,Chemical and Systems Biology","displayName":"Karlene Cimprich","lastName":"Cimprich"},{"researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Weis","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"William","primaryAppointment":"Professor,Structural Biology","displayName":"William Weis","lastName":"Weis"},{"researchInterest":"We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses.  A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4481&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stanley_Cohen","appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Stanley","primaryAppointment":"Professor,Genetics","displayName":"Stanley N. Cohen, MD","lastName":"Cohen"},{"researchInterest":"Rhiju Das strives to predict how sequence codes for structure in proteins, nucleic acids, and heteropolymers whose folds have yet to be explored. The Das group uses new computational and experimental tools to tackle the de novo modeling of protein and RNA folds, the high-throughput structure mapping of riboswitches and random RNAs, and the design of self-knotting and self-crystallizing nucleic acids.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10421&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Rhiju_Das","appointments":[{"appointment":"Assistant Professor,Biochemistry"}],"clinicalFocus":[],"firstName":"Rhiju","primaryAppointment":"Assistant Professor,Biochemistry","displayName":"Rhiju Das","lastName":"Das"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8562&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Phuoc_Tran","appointments":[{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Phuoc","primaryAppointment":"Member,Cancer Center","displayName":"Phuoc T. Tran","lastName":"Tran"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6213&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martha_Cyert","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Martha","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Martha Cyert","lastName":"Cyert"},{"researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Aaron_Straight","appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Aaron","primaryAppointment":"Assistant Professor,Biochemistry","displayName":"Aaron Straight","lastName":"Straight"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9946&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jayanth_Velandy Chodaparambil","appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"clinicalFocus":[],"firstName":"Jayanth","primaryAppointment":"Postdoctoral Research fellow, Structural Biology","displayName":"Jay Chodaparambil","lastName":"Velandy Chodaparambil"}]}