{"result":[{"researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ricardo_Dolmetsch","appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Ricardo","primaryAppointment":"Assistant Professor,Neurobiology","displayName":"Ricardo Dolmetsch","lastName":"Dolmetsch"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6245&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stuart_Thompson","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Stuart","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Stuart Thompson","lastName":"Thompson"},{"researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Tsien","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Tsien","lastName":"Tsien"},{"researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Isabella_Graef","appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Isabella","primaryAppointment":"Assistant Professor,Pathology","displayName":"Isabella Graef","lastName":"Graef"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8576&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Franklin_Mullins","appointments":[{"appointment":"Instructor,Pathology"}],"clinicalFocus":[{"focus":"Pathology"},{"focus":"Molecular Pathology"}],"firstName":"Franklin","primaryAppointment":"Instructor,Pathology","displayName":"Franklin Mullins","lastName":"Mullins"},{"researchInterest":"Ion channels and signal transduction;  patch clamp and fluorometric analysis; cell and molecular biology; cystic fibrosis gene therapy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4500&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Phyllis_Gardner","appointments":[{"appointment":"Professor,Medicine - Clinical Pharmacology"}],"clinicalFocus":[{"focus":"Clinical Pharmacology"}],"firstName":"Phyllis","primaryAppointment":"Professor,Medicine - Clinical Pharmacology","displayName":"Phyllis Gardner","lastName":"Gardner"},{"researchInterest":"Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.  Dynamics and functionality of specific T cell populations in human cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4282&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Davis","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Mark M. Davis","lastName":"Davis"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10159&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Andrew_Yoo","appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"clinicalFocus":[],"firstName":"Andrew","primaryAppointment":"Postdoctoral Research fellow, Pathology","displayName":"Andrew Yoo","lastName":"Yoo"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3795&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Lubert_Stryer","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Neurobiology"}],"clinicalFocus":[],"firstName":"Lubert","primaryAppointment":"Emeritus Faculty, Acad Council,Neurobiology","displayName":"Lubert Stryer","lastName":"Stryer"},{"researchInterest":"Cells respond to extracellular changes by activating signal transduction pathways, many of which are highly conserved. We study Ca2+-mediated signaling in a simple eukaryote, Saccharomyces cerevisiae. Using genetic, genomic, biochemical and cell biological approaches, we are examining how the Ca2+/calmodulin-regulated phosphatase, calcineurin, regulates gene expression and other cellular processes in response to environmental stress.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6213&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martha_Cyert","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Martha","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Martha Cyert","lastName":"Cyert"},{"researchInterest":"Our research program has several active projects:\r\n1.) Pulmonary Vascular Disease \u0096 Simvastatin reversed experimental pulmonary hypertension, and is safe for treatment of patients. Blinded clinical trials of efficacy are in progress.\r\n2.) Lung inflammation and regeneration (stem cells)\r\n3.) Lung surfactant rheology and oxidative stress\r\n4.) Gene regulation by RNA binding proteins, NF45 and NF90 through transcriptional and posttranscriptional mechanisms","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5961&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Kao","appointments":[{"appointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med"}],"clinicalFocus":[{"focus":"Pulmonary Disease"},{"focus":"Pulmonology (Lung) and Critical Care "}],"firstName":"Peter","primaryAppointment":"Associate Professor,Medicine - Pulmonary & Critical Care Med","displayName":"Peter Kao","lastName":"Kao"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kryn_Stankunas","appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Kryn","primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","displayName":"Kryn Stankunas","lastName":"Stankunas"},{"researchInterest":"The auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7527&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anthony_Ricci","appointments":[{"appointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)"},{"appointment":"Associate Professor (By courtesy),Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Anthony","primaryAppointment":"Associate Professor,Otolaryngology (Head and Neck Surgery)","displayName":"Anthony Ricci","lastName":"Ricci"},{"researchInterest":"Ovarian cancer\r\nEndometriosis\r\nCell Signal transduction","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8578&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Aya_Sultan","appointments":[{"appointment":"Instructor,Medicine - Oncology"},{"appointment":"Instructor,Obstetrics & Gynecology"}],"clinicalFocus":[{"focus":"Gynecology"},{"focus":"Obstetrics and Gynecology"}],"firstName":"Aya","primaryAppointment":"Instructor,Medicine - Oncology","displayName":"Aya Sultan","lastName":"Sultan"},{"researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Howard_Chang","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"Howard","primaryAppointment":"Associate Professor,Dermatology","displayName":"Howard Y. Chang","lastName":"Chang"},{"researchInterest":"Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4121&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yueh-Hsiu_Chien","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Yueh-Hsiu","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Yueh-hsiu Chien","lastName":"Chien"},{"researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jane_Parnes","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jane","primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","displayName":"Jane Parnes","lastName":"Parnes"},{"researchInterest":"We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels.  We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3813&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Miriam_Goodman","appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Miriam","primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","displayName":"Miriam B. Goodman","lastName":"Goodman"},{"researchInterest":"My laboratory has two major research interests.  First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.  Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Lewis","appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"firstName":"David","primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","displayName":"David B. Lewis","lastName":"Lewis"},{"researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anne_Brunet","appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Anne","primaryAppointment":"Assistant Professor,Genetics","displayName":"Anne Brunet","lastName":"Brunet"},{"researchInterest":"My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9248&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Maximilian_Diehn","appointments":[{"appointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy"}],"clinicalFocus":[],"firstName":"Maximilian","primaryAppointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy","displayName":"Maximilian Diehn, M.D., Ph.D.","lastName":"Diehn"},{"researchInterest":"Cardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4502&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Clusin","appointments":[{"appointment":"Associate Professor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Disease"}],"firstName":"William","primaryAppointment":"Associate Professor,Medicine - Cardiovascular Medicine","displayName":"William Clusin, MD","lastName":"Clusin"},{"researchInterest":"Ischemic optic neuropathy\r\nStem cell transplantation\r\nVision electrophysiology\r\nEye movement disorders\r\n\r\nOptic neuropathy\r\nOptic neuritis\r\nParaneoplastic syndromes","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7703&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yaping_Liao","appointments":[{"appointment":"Assistant Professor - Med Center Line,Ophthalmology"}],"clinicalFocus":[{"focus":"Neuro-Ophthalmology "},{"focus":"Ischemic Optic Neuropathy"},{"focus":"Eye Movement Disorders"},{"focus":"Ophthalmology"},{"focus":"Pseudotumor Cerebri"},{"focus":"Diplopia"},{"focus":"Optic Neuritis and Multiple Sclerosis"},{"focus":"Nystagmus"}],"firstName":"Yaping","primaryAppointment":"Assistant Professor - Med Center Line,Ophthalmology","displayName":"Y. Joyce Liao, M.D. Ph.D.","lastName":"Liao"}]}