{"result":[{"researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roeland_Nusse","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Roeland","primaryAppointment":"Professor,Developmental Biology","displayName":"Roeland Nusse","lastName":"Nusse"},{"researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jeffrey","primaryAppointment":"Associate Professor,Pathology","displayName":"Jeffrey Axelrod","lastName":"Axelrod"},{"researchInterest":"Genetic and molecular basis of respiratory system  development, maintenance, and disease in Drosophila, mouse, and human","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Krasnow","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Biochemistry","displayName":"Mark Krasnow","lastName":"Krasnow"},{"researchInterest":"Our laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis.  We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3938&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Chen","appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Assistant Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Assistant Professor,Chemical and Systems Biology","displayName":"James K. Chen","lastName":"Chen"},{"researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bingwei_Lu","appointments":[{"appointment":"Assistant Professor,Pathology"}],"clinicalFocus":[],"firstName":"Bingwei","primaryAppointment":"Assistant Professor,Pathology","displayName":"Bingwei Lu","lastName":"Lu"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bruce_Baker","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Bruce","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Bruce Baker","lastName":"Baker"},{"researchInterest":"Hedgehog signaling has been implicated in the induction or maintenance of up to 25% of human tumors and a variety of birth defects.  Our lab studies Sonic hedgehog (Shh) signaling in normal hair follicle development and in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin.  We are interested in how the local stromal environment regulates hedgehog signaling and hair follicle or tumor growth and invasion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4693&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anthony_Oro","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"},{"focus":"Skin Cancer "},{"focus":"Hair disorders"}],"firstName":"Anthony","primaryAppointment":"Associate Professor,Dermatology","displayName":"Anthony Oro  MD/PhD","lastName":"Oro"},{"researchInterest":"Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4159&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Margaret_Fuller","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Margaret","primaryAppointment":"Professor,Developmental Biology","displayName":"Margaret T. Fuller","lastName":"Fuller"},{"researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Howard_Chang","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"Howard","primaryAppointment":"Associate Professor,Dermatology","displayName":"Howard Y. Chang","lastName":"Chang"},{"researchInterest":"Craniofacial development and  patterning","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9172&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samantha_Brugmann","appointments":[{"appointment":"Postdoctoral Research fellow, Surgery"}],"clinicalFocus":[],"firstName":"Samantha","primaryAppointment":"Postdoctoral Research fellow, Surgery","displayName":"Samantha Brugmann","lastName":"Brugmann"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kryn_Stankunas","appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Kryn","primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","displayName":"Kryn Stankunas","lastName":"Stankunas"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10397&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Rothenberg","appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Postdoctoral Medical fellow, Medicine","displayName":"Michael Rothenberg","lastName":"Rothenberg"},{"researchInterest":"Dr. Helms' research interests center around craniofacial development and regenerative medicine.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6152&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jill_Helms","appointments":[{"appointment":"Associate Professor,Surgery - Plastic/Recon Surgery"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Jill","primaryAppointment":"Associate Professor,Surgery - Plastic/Recon Surgery","displayName":"Jill Helms","lastName":"Helms"},{"researchInterest":"We study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as \"self\" versus \"nonself\" or \"wanted\" versus \"unwanted\".","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3989&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Andrew_Fire","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"Andrew","primaryAppointment":"Professor,Pathology","displayName":"Andrew Fire","lastName":"Fire"},{"researchInterest":"We study the function and molecular evolution of proteins and noncoding functional elements in the genome.  Please refer to our web site for more information:  http://mendel.stanford.edu/SidowLab/index.html","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4393&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Arend_Sidow","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Arend","primaryAppointment":"Associate Professor,Pathology","displayName":"Arend Sidow","lastName":"Sidow"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including:  Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, parasites and viruses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4580&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Schneider","appointments":[{"appointment":"Associate Professor,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Associate Professor,Microbiology & Immunology","displayName":"David Schneider","lastName":"Schneider"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6234&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dmitri_Petrov","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Dmitri","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Dmitri Petrov","lastName":"Petrov"},{"researchInterest":"My laboratory uses a variety of genetic, cellular, and molecular approaches to study skeletal development in humans, mice, and  fish. Many of our studies begin with naturally occuring genetic traits that alter skeletal development. By isolating the genes responsible for these traits, it has been possible to identify key pathways that control creation of skeletal tissue, repair of fractures, susceptibility to arthritis, and dramatic modifications of skeletal morphology during vertebrate evolution","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4193&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Kingsley","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Professor,Developmental Biology","displayName":"David Kingsley","lastName":"Kingsley"},{"researchInterest":"Alternative modes of Wnt-signal transduction","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9613&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Renee_van Amerongen","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Renee","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Renee van Amerongen","lastName":"van Amerongen"},{"researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Roth","appointments":[{"appointment":"Emeritus (Active) Professor,Chemical and Systems Biology"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Emeritus (Active) Professor,Chemical and Systems Biology","displayName":"Richard Roth","lastName":"Roth"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"Tobin is a Senior Research Scholar in the Program for Genomics, Ethics, and Society at the Stanford Center for Biomedical Ethics. She obtained her Ph.D. in Developmental Biology from the University of Washington and did postdoctoral research in Genetics at the University of California, Berkeley and in Biochemistry at the University of California, San Francisco. She became a faculty member at the University of Oklahoma College of Medicine in 1983, where she established her independent research l","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6945&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sara_Tobin","appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Sr Research Scholar (PI Waiver),Center for Biomedical Ethics"}],"clinicalFocus":[],"firstName":"Sara","primaryAppointment":"Member,Cancer Center","displayName":"Sara L. (Sally) Tobin","lastName":"Tobin"},{"researchInterest":"My lab addresses two distinct questions.  That is, how can precise patterns of neuronal connections be genetically programmed during development, and how, once formed, can such circuits be used to mediate complex visual behaviors?   Using the fruit fly visual system as a model, we employ genetic approaches to manipulate the functions of genes and neurons. From this, we infer specific developmental roles for particular molecules, and infer specific computational roles for individual neurons.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3885&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Clandinin","appointments":[{"appointment":"Associate Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Associate Professor,Neurobiology","displayName":"Thomas Clandinin","lastName":"Clandinin"}]}