{"result":[{"researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matthew_Scott","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Matthew","primaryAppointment":"Professor,Developmental Biology","displayName":"Matthew Scott","lastName":"Scott"},{"researchInterest":"We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6244&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tim_Stearns","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Tim","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Tim Stearns","lastName":"Stearns"},{"researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roeland_Nusse","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Roeland","primaryAppointment":"Professor,Developmental Biology","displayName":"Roeland Nusse","lastName":"Nusse"},{"researchInterest":"The Reijo Pera Laboratory is focused on understanding key cell fates in the embryo, including the generation of pluripotent stem cells, somatic and germ cell lineages","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8036&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Renee_Reijo-Pera","appointments":[{"appointment":"Professor,Obstetrics & Gynecology - OB GYN Institutes"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Renee","primaryAppointment":"Professor,Obstetrics & Gynecology - OB GYN Institutes","displayName":"Renee A. Reijo Pera, Ph.D.","lastName":"Reijo-Pera"},{"researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Aaron_Straight","appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Aaron","primaryAppointment":"Assistant Professor,Biochemistry","displayName":"Aaron Straight","lastName":"Straight"},{"researchInterest":"Genetic and molecular basis of respiratory system  development, maintenance, and disease in Drosophila, mouse, and human","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Krasnow","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Biochemistry","displayName":"Mark Krasnow","lastName":"Krasnow"},{"researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bingwei_Lu","appointments":[{"appointment":"Assistant Professor,Pathology"}],"clinicalFocus":[],"firstName":"Bingwei","primaryAppointment":"Assistant Professor,Pathology","displayName":"Bingwei Lu","lastName":"Lu"},{"researchInterest":"Genetic and cell biological analyses of signals controlling cell polarity and cell proliferation and differentiation.  Frizzled signaling and cytoskeletal organization.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4410&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Jeffrey_Axelrod","appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jeffrey","primaryAppointment":"Associate Professor,Pathology","displayName":"Jeffrey Axelrod","lastName":"Axelrod"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6234&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dmitri_Petrov","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Dmitri","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Dmitri Petrov","lastName":"Petrov"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6206&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bruce_Baker","appointments":[{"appointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Bruce","primaryAppointment":"Emeritus (Active) Professor,Biology (School of Humanities and Sciences)","displayName":"Bruce Baker","lastName":"Baker"},{"researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","href":"http://med.stanford.edu/profiles/John_Pringle","appointments":[{"appointment":"Professor,Genetics"}],"clinicalFocus":[],"firstName":"John","primaryAppointment":"Professor,Genetics","displayName":"John R. Pringle","lastName":"Pringle"},{"researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Maxence_Nachury","appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Maxence","primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","displayName":"Maxence Nachury","lastName":"Nachury"},{"researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Patrick_Brown","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Patrick","primaryAppointment":"Professor,Biochemistry","displayName":"Patrick O. Brown","lastName":"Brown"},{"researchInterest":"We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including:  Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, parasites and viruses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4580&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Schneider","appointments":[{"appointment":"Associate Professor,Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Associate Professor,Microbiology & Immunology","displayName":"David Schneider","lastName":"Schneider"},{"researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Ferrell","appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Professor,Chemical and Systems Biology","displayName":"James Ferrell","lastName":"Ferrell"},{"researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ronald_Davis","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ronald","primaryAppointment":"Professor,Biochemistry","displayName":"Ronald Davis","lastName":"Davis"},{"researchInterest":"Tobin is a Senior Research Scholar in the Program for Genomics, Ethics, and Society at the Stanford Center for Biomedical Ethics. She obtained her Ph.D. in Developmental Biology from the University of Washington and did postdoctoral research in Genetics at the University of California, Berkeley and in Biochemistry at the University of California, San Francisco. She became a faculty member at the University of Oklahoma College of Medicine in 1983, where she established her independent research l","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6945&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sara_Tobin","appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Sr Research Scholar (PI Waiver),Center for Biomedical Ethics"}],"clinicalFocus":[],"firstName":"Sara","primaryAppointment":"Member,Cancer Center","displayName":"Sara L. (Sally) Tobin","lastName":"Tobin"},{"researchInterest":"Cell cycle and cyclin control of DNA replication .","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4463&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Peter_Jackson","appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Peter","primaryAppointment":"Member,Cancer Center","displayName":"Peter Jackson","lastName":"Jackson"},{"researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ashby_Morrison","appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Ashby","primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","displayName":"Ashby Morrison","lastName":"Morrison"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10397&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Rothenberg","appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Postdoctoral Medical fellow, Medicine","displayName":"Michael Rothenberg","lastName":"Rothenberg"},{"researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Weis","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"William","primaryAppointment":"Professor,Structural Biology","displayName":"William Weis","lastName":"Weis"},{"researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Howard_Chang","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"Howard","primaryAppointment":"Associate Professor,Dermatology","displayName":"Howard Y. Chang","lastName":"Chang"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6209&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Steven_Block","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Applied Physics"},{"appointment":"Senior Fellow (By courtesy),Spogli Inst for Intrntl Studies"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Steven","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Steven M. Block","lastName":"Block"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9649&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_Tran","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"David Tran","lastName":"Tran"}]}