{"result":[{"lastName":"Negrin","clinicalFocus":[{"focus":"Blood and Marrow Transplantation"},{"focus":"Hematology"}],"appointments":[{"appointment":"Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4138&type=small&showNoImage","displayName":"Robert Negrin","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Negrin","researchInterest":"Our labaratory focuses on the study of immune recognition by T and NK cells with special emphasis on graft vs host disease and graft vs tumor reactions. We utilize both murine and human systems in an effort to enhance graft vs tumor reactions while controlling graft vs host disease. We have developed bioluminescence models in collaboration with the Contag laboratory to study the trafficking of immune effector cells with a special emphasis on NK, T and regulatory T cells."},{"lastName":"Fathman","clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","displayName":"C. Garrison Fathman","firstName":"C","href":"http://med.stanford.edu/profiles/C_Fathman","researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome.  Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D."},{"lastName":"Engleman","clinicalFocus":[{"focus":"Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4490&type=small&showNoImage","displayName":"Edgar Engleman","firstName":"Edgar","href":"http://med.stanford.edu/profiles/Edgar_Engleman","researchInterest":"Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease."},{"lastName":"Lowsky","clinicalFocus":[{"focus":"Blood and Marrow Transplantation"},{"focus":"Hematology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3811&type=small&showNoImage","displayName":"Robert Lowsky","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Lowsky","researchInterest":"Dr. Lowsky's research is focused on understanding the role of regulatory T cells in the prevention of GVHD and in promoting immune tolerance following organ transplantation."},{"lastName":"Weissman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology - Stem Cell Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","displayName":"Irving Weissman","firstName":"Irving","href":"http://med.stanford.edu/profiles/Irving_Weissman","researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","displayName":"Leonard Herzenberg","firstName":"Leonard","href":"http://med.stanford.edu/profiles/Leonard_Herzenberg","researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC)."},{"lastName":"Laport","clinicalFocus":[{"focus":"Blood and Marrow Transplantation"},{"focus":"Hematology"},{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4546&type=small&showNoImage","displayName":"Ginna G. Laport","firstName":"Ginna","href":"http://med.stanford.edu/profiles/Ginna_Laport","researchInterest":"haploidentical transplantation, follicular lymphoma, adoptive immunotherapy,supportive care"},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","displayName":"Leonore A. Herzenberg","firstName":"Leonore","href":"http://med.stanford.edu/profiles/Leonore_Herzenberg","researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays."},{"lastName":"Higgins","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4038&type=small&showNoImage","displayName":"John Higgins","firstName":"John","href":"http://med.stanford.edu/profiles/John_Higgins","researchInterest":"I work as a diagnostic surgical pathologist doing tissue and cDNA microarray-based translational research in renal neoplasia and medical renal disease. Subspecialty areas of clinical interest include diagnostic immunohistochemistry, renal, hepatic and transplant pathology."},{"lastName":"Lewis","clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","displayName":"David B. Lewis","firstName":"David","href":"http://med.stanford.edu/profiles/David_Lewis","researchInterest":"My laboratory has two major research interests.  First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.  Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines."},{"lastName":"Kambham","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Renal Pathology"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3829&type=small&showNoImage","displayName":"Neeraja Kambham","firstName":"Neeraja","href":"http://med.stanford.edu/profiles/Neeraja_Kambham","researchInterest":"Research interests primarily involve medical diseases of the native and transplant kidney. Other interests include liver transplantation pathology and gastrointestinal pathology."},{"lastName":"Wren","clinicalFocus":[{"focus":"Surgical Oncology"},{"focus":"Colorectal Surgery"},{"focus":"General Surgery"}],"appointments":[{"appointment":"Professor - Med Center Line,Surgery - General Surgery"}],"primaryAppointment":"Professor - Med Center Line,Surgery - General Surgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4440&type=small&showNoImage","displayName":"Sherry M. Wren","firstName":"Sherry","href":"http://med.stanford.edu/profiles/Sherry_Wren","researchInterest":"Our research interests are primarily in surgical oncology, especially gastrointestinal cancers. We are also developing new research studies in surgical outcomes."},{"lastName":"Sibley","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Professor,Pathology"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4113&type=small&showNoImage","displayName":"Richard Sibley","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Sibley","researchInterest":"Immunologic mechanism of rejection in humans and animal, models of organ transplantation; histological definition of clinical pathology studies of various renal disorders."},{"lastName":"Johnston","clinicalFocus":[{"focus":"BMT"},{"focus":"Blood and Marrow Transplantation"},{"focus":"Hematology"},{"focus":"Graft-Versus-Host Disease"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Division: Blood and  \r\nMarrow Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4572&type=small&showNoImage","displayName":"Laura Johnston","firstName":"Laura","href":"http://med.stanford.edu/profiles/Laura_Johnston","researchInterest":"Clinical research in allogeneic and autologous hematopoietic cell transplantation (HCT), more specifically, allogeneic transplantation and graft versus host disease. Exploring methods of improving prevention and treatment of GVHD as well as the long term follow-up and/or quality of life of affected patients."},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4282&type=small&showNoImage","displayName":"Mark M. Davis","firstName":"Mark","href":"http://med.stanford.edu/profiles/Mark_Davis","researchInterest":"Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.  Dynamics and functionality of specific T cell populations in human cancer."},{"lastName":"Butcher","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4498&type=small&showNoImage","displayName":"Eugene Butcher","firstName":"Eugene","href":"http://med.stanford.edu/profiles/Eugene_Butcher","researchInterest":"Our interests include: \r\n1) The physiology and significance of lymphocyte homing in local and systemic immunity; \r\n2) biochemical and genetic studies of molecules that direct leukocyte recruitment; \r\n3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; \r\n4) vascular differentiation in normal and pathologic inflammatory states; \r\n5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs."},{"lastName":"Stockerl-Goldstein","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4547&type=small&showNoImage","displayName":"Keith Stockerl-Goldstein, M.D.","firstName":"Keith","href":"http://med.stanford.edu/profiles/Keith_Stockerl-Goldstein","researchInterest":"Clinical investigation of bone marrow and peripheral blood progenitor cell transplantation for lymphoproliferative disease and solid tumors; immunotherapy following high-dose therapy and transplantation; supportive care following transplantation; immune system reconstitution."},{"lastName":"Robinson","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Assistant Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4730&type=small&showNoImage","displayName":"William Robinson","firstName":"William","href":"http://med.stanford.edu/profiles/William_Robinson","researchInterest":"Our lab studies the molecular mechanisms of and develops therapies to treat autoimmune and rheumatic diseases, with a focus on rheumatoid arthritis, multiple sclerosis, and osteoarthritis. \r\n\r\nThe overriding objectives of our laboratory are:\r\n\r\n1. To investigate the mechanisms underlying autoimmune diseases.\r\n\r\n2. To develop diagnostics and therapeutics for autoimmune diseases.\r\n\r\n3. To investigate the role of inflammation in osteoarthritis."},{"lastName":"Parnes","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","displayName":"Jane Parnes","firstName":"Jane","href":"http://med.stanford.edu/profiles/Jane_Parnes","researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease."},{"lastName":"Blume","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Emeritus (Active) Professor,Medicine - Division: Blood and  \r\nMarrow Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4180&type=small&showNoImage","displayName":"Karl Blume","firstName":"Karl","href":"http://med.stanford.edu/profiles/Karl_Blume","researchInterest":"Allogeneic and autologous bone marrow transplantation (experimental and clinical) as a treatment modality for leukemia, lymphoma, Hodgkin's disease, multiple myeloma, hereditary disorders, immune defects and selective solid tumors. Development of novel preparatory regimens to prevent the recurrence of the underlying malignancies. Studies for the prevention of acute and chronic graft-versus-host disease. Testing of new anti-viral agents to prevent or treat viral infections."},{"lastName":"Martinez","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Surgery - Multi-Organ Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4474&type=small&showNoImage","displayName":"Olivia Martinez","firstName":"Olivia","href":"http://med.stanford.edu/profiles/Olivia_Martinez","researchInterest":"Cell death pathways in EBV B cell lymphomas; role of cytokines and immunosuppression in growth and survival of EBV B cell lymphomas; cytokine pathways in graft rejection; identification of regulatory T cell subsets in alloreactivity; role of co-stimulation in alloreactivity; "},{"lastName":"Bonham","clinicalFocus":[{"focus":"General Surgery"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Liver Transplantation"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Surgery - Multi-Organ Transplantation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3884&type=small&showNoImage","displayName":"Clark Bonham","firstName":"Clark","href":"http://med.stanford.edu/profiles/Clark_Bonham","researchInterest":""},{"lastName":"Chien","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4121&type=small&showNoImage","displayName":"Yueh-hsiu Chien","firstName":"Yueh-Hsiu","href":"http://med.stanford.edu/profiles/Yueh-Hsiu_Chien","researchInterest":"Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses."},{"lastName":"Grumet","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Pathology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4535&type=small&showNoImage","displayName":"Frank Carl Grumet","firstName":"Frank","href":"http://med.stanford.edu/profiles/Frank_Grumet","researchInterest":"Work in our laboratory is focused on the study of the human major histocompatibility (HLA) complex. We are seeking to characterize the genes and gene products of this complex and to understand their role in determining transplantation and transfusion compatibility. Laboratory work on this topic ranges from clinical studies correlating graft rejection with HLA antigens identified by classical serology or DNA typing."},{"lastName":"George","clinicalFocus":[{"focus":"Anatomic/Clinical Pathology"},{"focus":"Pathology and Laboratory Medicine"},{"focus":"Hematopathology and Laboratory Hematology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3926&type=small&showNoImage","displayName":"Tracy George","firstName":"Tracy","href":"http://med.stanford.edu/profiles/Tracy_George","researchInterest":"Translational research in hematopathology is where my research interests concentrate, including the investigation of the molecular basis of select hematopathology malignancies using fluorescence in situ hybridization, flow cytometry and immunohistochemistry. Areas of study include post-transplant and immunodeficiency-related lymphoproliferative disorders, reactive lymphadenopathies, and the chronic myeloproliferative disorders."}]}