{"result":[{"researchInterest":"We are interested in the biologic effect of gene expression changes that occur in the solid tumor.  Many of these expression changes are due to the micro-physiology within the tumor.  Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention.  We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4577&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Nicholas_Denko","appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Nicholas","primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Biology","displayName":"Nicholas Denko","lastName":"Denko"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9968&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Denise_Chan","appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"clinicalFocus":[],"firstName":"Denise","primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","displayName":"Denise Chan","lastName":"Chan"},{"researchInterest":"The focus of my laboratory is to understand the role of hypoxia and the tumor microenvironment on malignant progression. My clinical area of interest is in the application of chemoradiotherapy and stereotactic radiosurgery for GI maligancies","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4729&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Albert_Koong","appointments":[{"appointment":"Assistant Professor,Radiation Oncology - Radiation Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Colorectal Cancer - Radiation Oncology"},{"focus":"Esophageal Cancer"},{"focus":"Esophageal Cancer - Radiation Oncology"},{"focus":"Liver Cancer"},{"focus":"Liver Cancer - Radiation Oncology"},{"focus":"Pancreatic Cancer "},{"focus":"Pancreatic Cancer - Radiation Oncology"},{"focus":"Radiation Oncology"},{"focus":"Rectal Cancer "},{"focus":"Rectal Cancer - Radiation Oncology"},{"focus":"Stomach Cancer "},{"focus":"Stomach Cancer - Radiation Oncology"}],"firstName":"Albert","primaryAppointment":"Assistant Professor,Radiation Oncology - Radiation Therapy","displayName":"Albert Koong","lastName":"Koong"},{"researchInterest":"We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to exploit tumor hypoxia with drugs activated by hypoxia and anaerobic bacteria as tumor-specific gene therapy vectors. We are also testing ways of inhibiting the bone marrow rescue of the tumor vasculature following therapy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4536&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Martin_Brown","appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Martin","primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","displayName":"Martin Brown","lastName":"Brown"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9143&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Adam_Krieg","appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"clinicalFocus":[],"firstName":"Adam","primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","displayName":"Adam Krieg","lastName":"Krieg"},{"researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Howard_Chang","appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Dermatology"}],"firstName":"Howard","primaryAppointment":"Associate Professor,Dermatology","displayName":"Howard Y. Chang","lastName":"Chang"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"We have six main areas of current interest: 1) Cranial Suture Developmental Biology, 2)Distraction Osteogenesis, 3) Cleft Palate and Lip Biology, 4)Keloid and Hypertrophic Scar Biology, 5) Scarless Fetal Wound Healing, 6) Novel Gene and Stem Cell Therapeutic Approaches.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4338&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Longaker","appointments":[{"appointment":"Professor,Surgery - Plastic/Recon Surgery"},{"appointment":"Professor (By courtesy),Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Plastic Surgery"},{"focus":"Plastic Surgery, Pediatric"}],"firstName":"Michael","primaryAppointment":"Professor,Surgery - Plastic/Recon Surgery","displayName":"Michael Longaker","lastName":"Longaker"},{"researchInterest":"My laboratory research interest focusses on the identification of serum markers for tumor hypoxia and for prognosis in patients with head and neck or lung cancers. I am also conducting a number of clinical trials specifically in patients with these tumors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4003&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Quynh-Thu_Le","appointments":[{"appointment":"Professor - Med Center Line,Radiation Oncology - Radiation Therapy"},{"appointment":"Professor - Med Center Line (By courtesy),Otolaryngology (Head and Neck Surgery)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Head and Neck Cancers"},{"focus":"Head and Neck Cancers - Radiation Oncology"},{"focus":"Larynx Cancer "},{"focus":"Larynx Cancer - Radiation Oncology"},{"focus":"Lung Cancer - Radiation Oncology"},{"focus":"Oral Cavity Cancer  "},{"focus":"Oral Cavity Cancer - Radiation Oncology"},{"focus":"Radiation Oncology"},{"focus":"Salivary Gland Tumors"},{"focus":"Salivary Gland Tumors - Radiation Oncology"},{"focus":"Sarcomas - Soft Tissue "},{"focus":"Sarcomas - Soft Tissue - Radiation Oncology"},{"focus":"Skull Base Tumors "},{"focus":"Skull Base Tumors - Radiation Oncology"}],"firstName":"Quynh-Thu","primaryAppointment":"Professor - Med Center Line,Radiation Oncology - Radiation Therapy","displayName":"Quynh-Thu Le","lastName":"Le"},{"researchInterest":"My laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the new field of molecular imaging. Methods to image gene expression in living subjects have been developed.  Newer approaches to image fundamental cellular events with optical and radiolabeled probes are under active investigation. These imaging approaches are expected to have a fundamental impact in the study of cancer biology,  as well as in molecular therapeutics including gene therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3971&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sanjiv_Gambhir","appointments":[{"appointment":"Professor,Radiology - Nuclear Medicine"},{"appointment":"Professor (By courtesy),Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Nuclear Medicine"},{"focus":"Radiology"},{"focus":"PET Scan"}],"firstName":"Sanjiv","primaryAppointment":"Professor,Radiology - Nuclear Medicine","displayName":"Sanjiv Sam Gambhir, MD, PhD","lastName":"Gambhir"},{"researchInterest":"My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5931&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dean_Felsher","appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hodgkin's Disease"},{"focus":"Hodgkin's Disease - Hematology"},{"focus":"Hodgkin's Disease - Medical Oncology"},{"focus":"Lymphoma "},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Dean","primaryAppointment":"Associate Professor,Medicine - Oncology","displayName":"Dean W. Felsher","lastName":"Felsher"},{"researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anne_Brunet","appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Anne","primaryAppointment":"Assistant Professor,Genetics","displayName":"Anne Brunet","lastName":"Brunet"},{"researchInterest":"My research interests include the influence of tumor microenvironment on generation of circulating tumor cells (CTCs), which circulate the body and metastasize to distant organs. Specific interests: 1. The role of tumor hypoxia and tumor anoxia in generation of CTCs; 2. The role of anoxia factors in determing resistance to anti-angiogensis therapy; 3. Exploiting anoxia pathways in cancer imaging and CTC imaging; 4. Exploiting anoxia induced nutritional pathways in cancer therapy and imaging.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8979&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Kurosh_Ameri","appointments":[{"appointment":"Postdoctoral Research fellow, Surgery"}],"clinicalFocus":[],"firstName":"Kurosh","primaryAppointment":"Postdoctoral Research fellow, Surgery","displayName":"Kurosh Ameri","lastName":"Ameri"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9869&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Olga_Razorenova","appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"clinicalFocus":[],"firstName":"Olga","primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","displayName":"Olga Razorenova","lastName":"Razorenova"},{"researchInterest":"Molecular and cellular mechanisms that control muscle and neuronal growth; stem cell biology, differentiation, and tumorigenicity. Regulating stem cell fate in vitro and in vivo. Stem cell therapies. Hematopoietic and muscle stem cells. Characterizing and bioengineering stem cell niches. Nuclear reprogramming. Muscle development and disease. Drug delivery. Tracking cell behavior in vitro and in vivo. Understanding tissue degeneration and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4517&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Helen_Blau","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Helen","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Helen M. Blau","lastName":"Blau"},{"researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Clarke","appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Michael","primaryAppointment":"Professor,Medicine - Oncology","displayName":"Michael F. Clarke, M.D.","lastName":"Clarke"},{"researchInterest":"Our interests in clude 1) study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2) use of radiation as an immune modulator for optimization of transplant regimens, and 3) the role of radiation in tumor vaccine strategies.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4699&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Susan_Knox","appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Radiation Oncology"},{"focus":"Radiation Therapy"}],"firstName":"Susan","primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Therapy","displayName":"Susan Knox","lastName":"Knox"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14774&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ramasamy_Paulmurugan","appointments":[{"appointment":"Acting Assistant Professor,Radiology"}],"clinicalFocus":[],"firstName":"Ramasamy","primaryAppointment":"Acting Assistant Professor,Radiology","displayName":"Ramasamy Paulmurugan","lastName":"Paulmurugan"},{"researchInterest":"My research is in applied statistics and biostatistics. I specialize in \u000bcomputer-intensive methods for regression and classification, bootstrap, cross-validation\u000band statistical inference, and signal and image analysis for medical diagnosis.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4688&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Tibshirani","appointments":[{"appointment":"Professor,Health Research & Policy - Biostatistics"},{"appointment":"Professor,Statistics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Robert","primaryAppointment":"Professor,Health Research & Policy - Biostatistics","displayName":"Robert Tibshirani","lastName":"Tibshirani"},{"researchInterest":"Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNA\u000bdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4066&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Ford","appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Associate Professor (By courtesy),Pediatrics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Cancer Genetics"},{"focus":"Gastrointestinal Cancers - Genetics"},{"focus":"Gastrointestinal Cancers - Medical Oncology"},{"focus":"Breast Cancer - Genetics"},{"focus":"Ovarian Cancer - Genetics"},{"focus":"Medical Oncology"}],"firstName":"James","primaryAppointment":"Associate Professor,Medicine - Oncology","displayName":"James Ford","lastName":"Ford"},{"researchInterest":"The cellular and molecular basis for brain cell injury in stroke is our focus.  Astrocytes and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles.  We study gene therapy with heat shock proteins, changes in mitochondrial function, oxidative stress and inflammation during ischemia. We also model cell death pathways and the effects of Hsp70.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4657&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Rona_Giffard","appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Rona","primaryAppointment":"Professor,Anesthesia","displayName":"Rona Giffard","lastName":"Giffard"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10387&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Young Min_Chung","appointments":[{"appointment":"Postdoctoral Research fellow, Obstetrics & Gynecology"}],"clinicalFocus":[],"firstName":"Young Min","primaryAppointment":"Postdoctoral Research fellow, Obstetrics & Gynecology","displayName":"Young Min Chung","lastName":"Chung"},{"researchInterest":"Geoffrey Gurtner's Lab is interested in understanding the mecahnism of new blood vessel growth following injury and how pathways of tissue regeneration and fibrosis interact in wound healing.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6890&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Geoffrey_Gurtner","appointments":[{"appointment":"Professor - Med Center Line,Surgery - Plastic/Recon Surgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Plastic Surgery"}],"firstName":"Geoffrey","primaryAppointment":"Professor - Med Center Line,Surgery - Plastic/Recon Surgery","displayName":"Geoffrey Gurtner","lastName":"Gurtner"},{"researchInterest":"chemoprevetion, HDAC inhibitors, miRNAs, tumor suppressor genes","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10537&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Emily_Noonan","appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"clinicalFocus":[],"firstName":"Emily","primaryAppointment":"Postdoctoral Research fellow, Medicine","displayName":"Emily Noonan Ph.D.","lastName":"Noonan"},{"researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Linda_Boxer","appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"firstName":"Linda","primaryAppointment":"Professor,Medicine - Hematology","displayName":"Linda Boxer","lastName":"Boxer"}]}