{"result":[{"researchInterest":"We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function.  Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4176&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Lewis","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Lewis","lastName":"Lewis"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6245&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stuart_Thompson","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"Stuart","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Stuart Thompson","lastName":"Thompson"},{"researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","href":"http://med.stanford.edu/profiles/David_McKay","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","displayName":"David B. McKay","lastName":"McKay"},{"researchInterest":"Research in Dr. Deisseroth's laboratory focuses on developing optical, molecular and cellular tools to observe, perturb, and re-engineer brain circuits. His laboratory is based in the James H. Clark Center at Stanford and has developed optogenetic and tissue engineering methods, employing techniques spanning electrophysiology, molecular biology, optics, neural activity imaging, animal behavior, and computational neural network modeling.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6080&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Karl_Deisseroth","appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Associate Professor,Psychiatry & Behavioral Science"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[{"focus":"Psychiatry"}],"firstName":"Karl","primaryAppointment":"Assistant Professor,Bioengineering","displayName":"Karl Deisseroth","lastName":"Deisseroth"},{"researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Weis","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"William","primaryAppointment":"Professor,Structural Biology","displayName":"William Weis","lastName":"Weis"},{"researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ricardo_Dolmetsch","appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Ricardo","primaryAppointment":"Assistant Professor,Neurobiology","displayName":"Ricardo Dolmetsch","lastName":"Dolmetsch"},{"researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Richard_Tsien","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Tsien","lastName":"Tsien"},{"researchInterest":"Ion channels and signal transduction;  patch clamp and fluorometric analysis; cell and molecular biology; cystic fibrosis gene therapy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4500&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Phyllis_Gardner","appointments":[{"appointment":"Professor,Medicine - Clinical Pharmacology"}],"clinicalFocus":[{"focus":"Clinical Pharmacology"}],"firstName":"Phyllis","primaryAppointment":"Professor,Medicine - Clinical Pharmacology","displayName":"Phyllis Gardner","lastName":"Gardner"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9569&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Antony_Boucard","appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"clinicalFocus":[],"firstName":"Antony","primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","displayName":"Antony Boucard","lastName":"Boucard"},{"researchInterest":"Dr. Dodd is involved in clinical trials using endovascular coils that have a fiber coating that help heal aneurysms of the neck and can prevent an aneurysm from reforming. He uses minimally invasive endoscopic techniques to treat brain tumors.\r\n\r\nDodd's research interests are in cerebral blood vessel reactivity and stroke.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6790&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Robert_Dodd","appointments":[{"appointment":"Assistant Professor - Med Center Line,Neurosurgery"},{"appointment":"Assistant Professor - Med Center Line,Radiology"}],"clinicalFocus":[{"focus":"Interventional Neuroradiology"},{"focus":"Neurosurgery"}],"firstName":"Robert","primaryAppointment":"Assistant Professor - Med Center Line,Neurosurgery","displayName":"Robert Dodd","lastName":"Dodd"},{"researchInterest":"Molecular theories of anesthesia. My emphasis is on the molecular interactions of inhalational anesthetics and alcohol. I perform computational chemistry simulations on how these molecules bind to putative receptor sites. I am also interested in modeling receptor proteins in which chimeras cause loss or enhancement of anesthetic sensitivity.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4617&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Trudell","appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Professor,Anesthesia","displayName":"James Trudell","lastName":"Trudell"},{"researchInterest":"Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology.  We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4370&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Chris_Garcia","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Chris","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Chris Garcia","lastName":"Garcia"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9820&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Masayuki_Yazawa","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Masayuki","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Masayuki Yazawa","lastName":"Yazawa"},{"researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Ferrell","appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Professor,Chemical and Systems Biology","displayName":"James Ferrell","lastName":"Ferrell"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12553&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Valeria_Vasquez","appointments":[{"appointment":"Postdoctoral Research fellow, Mechanical Engineering"}],"clinicalFocus":[],"firstName":"Valeria","primaryAppointment":"Postdoctoral Research fellow, Mechanical Engineering","displayName":"Valeria Vasquez","lastName":"Vasquez"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Yahli_Lorch","appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"clinicalFocus":[],"firstName":"Yahli","primaryAppointment":"Associate Professor (Research),Structural Biology","displayName":"Yahli Lorch","lastName":"Lorch"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9452&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ofer_Yizhar","appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"clinicalFocus":[],"firstName":"Ofer","primaryAppointment":"Postdoctoral Research fellow, Bioengineering","displayName":"Ofer Yizhar","lastName":"Yizhar"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9040&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Avraham_Samson","appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"clinicalFocus":[],"firstName":"Avraham","primaryAppointment":"Postdoctoral Research fellow, Structural Biology","displayName":"Avraham Samson","lastName":"Samson"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9464&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Beat_Christen","appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"clinicalFocus":[],"firstName":"Beat","primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","displayName":"Beat Christen","lastName":"Christen"},{"researchInterest":"Structure, dynamics and function of proteins involved in transport and regulatory processes; high resolution nuclear magnetic resonance studies of conformational transitions and protein folding; study of the mechanism of action of the trp-repressor, ankyrin-domain proteins and the development of programs to calculate protein solution structure","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4190&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Oleg_Jardetzky","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"clinicalFocus":[],"firstName":"Oleg","primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","displayName":"Oleg Jardetzky","lastName":"Jardetzky"},{"researchInterest":"Cardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4502&type=small&showNoImage","href":"http://med.stanford.edu/profiles/William_Clusin","appointments":[{"appointment":"Associate Professor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Disease"}],"firstName":"William","primaryAppointment":"Associate Professor,Medicine - Cardiovascular Medicine","displayName":"William Clusin, MD","lastName":"Clusin"},{"researchInterest":"Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Levitt","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Professor,Structural Biology","displayName":"Michael Levitt","lastName":"Levitt"},{"researchInterest":"Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8533&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Thomas_Sudhof","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Psychiatry & Behavioral Science"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Thomas Sudhof","lastName":"Sudhof"},{"researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Anne_Brunet","appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Anne","primaryAppointment":"Assistant Professor,Genetics","displayName":"Anne Brunet","lastName":"Brunet"},{"researchInterest":"Our research is concerned with elucidating the basic cellular molecular mechanisms that underly the recognition and destruction of misfolded or mis-assembled proteins in eukaryotic cells.  We study dominatly inherited human neurodegenerative disorders like Alzheimer's, Huntington's or Parkinson's diseases that are caused by the failure of this system to effectively recognize and destroy such proteins.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6227&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Ron_Kopito","appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Ron","primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","displayName":"Ron Kopito","lastName":"Kopito"}]}