{"result":[{"lastName":"Chen","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Psychiatry & Behavioral Science - Center for Interdisciplinary Brain Sciences Research"}],"primaryAppointment":"Associate Professor,Psychiatry & Behavioral Science - Center for Interdisciplinary Brain Sciences Research","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20934&type=small&showNoImage","displayName":"Lu Chen","firstName":"Lu","href":"http://med.stanford.edu/profiles/Lu_Chen","researchInterest":"What distinguishes us humans from other animals is our ability to undergo complex behavior. The synapses are the structural connection between neurons that mediates the communication between neurons, which underlies our various cognitive function. My research program aims to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation."},{"lastName":"Aoto","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14864&type=small&showNoImage","displayName":"Jason Aoto","firstName":"Jason","href":"http://med.stanford.edu/profiles/Jason_Aoto","researchInterest":""},{"lastName":"Malenka","clinicalFocus":[],"appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4670&type=small&showNoImage","displayName":"Robert Malenka","firstName":"Robert","href":"http://med.stanford.edu/profiles/Robert_Malenka","researchInterest":"Long-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy."},{"lastName":"Hestrin","clinicalFocus":[],"appointments":[{"appointment":"Professor,Comparative Medicine"}],"primaryAppointment":"Professor,Comparative Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4343&type=small&showNoImage","displayName":"Shaul Hestrin","firstName":"Shaul","href":"http://med.stanford.edu/profiles/Shaul_Hestrin","researchInterest":"The main interest of my lab is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. Our approach includes recordings from multiple cells, calcium imaging, two-photon imaging and viral-based optogenetic methods to activate  cortical neurons as well as cortical afferents."},{"lastName":"Kerchner","clinicalFocus":[{"focus":"Alzheimer's Disease"},{"focus":"Mild Cognitive Impairment"},{"focus":"Dementia"},{"focus":"Behavioral Neurology"},{"focus":"Neurodegenerative Disease"},{"focus":"Neuropsychology"},{"focus":"Neurology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences"}],"primaryAppointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15338&type=small&showNoImage","displayName":"Geoffrey Kerchner","firstName":"Geoffrey","href":"http://med.stanford.edu/profiles/Geoffrey_Kerchner","researchInterest":"Dr. Kerchner is a behavioral neurologist who cares for patients with Alzheimer's disease and other age-related neurodegenerative illnesses. He studies the use of ultra-high field MRI and other advanced neuroimaging technologies to reveal how these diseases affect the microscopic structure and circuitry of the brain, with the intent of creating new strategies for early diagnosis. Dr. Kerchner also supervises the participation of patients in clinical trials for Alzheimer\u0092s disease."},{"lastName":"MacIver","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor (Research),Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4009&type=small&showNoImage","displayName":"M Bruce MacIver","firstName":"M","href":"http://med.stanford.edu/profiles/M_MacIver","researchInterest":"We study drug effects on the nervous system. Cellular, synaptic and molecular drug actions are investigated using electrophysiological and pharmacological tools in cortical/hippocampal brain slice preparations. We are also interested in mechanisms of neuronal integration and synchronization, especially related to patterns of EEG activity seen in vivo and in brain slices."},{"lastName":"Fuccillo","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8634&type=small&showNoImage","displayName":"Marc Fuccillo","firstName":"Marc","href":"http://med.stanford.edu/profiles/Marc_Fuccillo","researchInterest":""},{"lastName":"Kendig","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Anesthesia"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4161&type=small&showNoImage","displayName":"Joan Kendig","firstName":"Joan","href":"http://med.stanford.edu/profiles/Joan_Kendig","researchInterest":"My laboratory tries to find out how pharmacologic agents used in the practice of anesthesia (general anesthetic and analgesic agents) lead to therapeutically desireable endpoints including unconsciousness, immobility and absence of pain. The old idea that general anesthetics are uniformly non-specific \"membrane stabilizers\" is giving way to a new realization that these agents exert specific actions on particular ion channels and intracellular signalling systems."},{"lastName":"Chen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20866&type=small&showNoImage","displayName":"Lulu Chen","firstName":"Lulu","href":"http://med.stanford.edu/profiles/Lulu_Chen","researchInterest":""},{"lastName":"Polepalli","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12891&type=small&showNoImage","displayName":"Jai Polepalli","firstName":"Jai","href":"http://med.stanford.edu/profiles/Jai_Polepalli","researchInterest":""},{"lastName":"Ding","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurology & Neurological Sciences"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=32293&type=small&showNoImage","displayName":"Jun Ding","firstName":"Jun","href":"http://med.stanford.edu/profiles/Jun_Ding","researchInterest":"Neural circuits of movement control in health and movement disorders"},{"lastName":"Madison","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4321&type=small&showNoImage","displayName":"Daniel V. Madison","firstName":"Vernon","href":"http://med.stanford.edu/profiles/Vernon_Madison","researchInterest":"Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system."},{"lastName":"Garner","clinicalFocus":[],"appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3890&type=small&showNoImage","displayName":"Craig C. Garner","firstName":"Craig","href":"http://med.stanford.edu/profiles/Craig_Garner","researchInterest":"Our laboratory is studying synapse formation, stability and elimination at a variety of levels, e.g. from molecules to behavior.  A primary focus of the lab is to understanding the role that individual molecules play in the assembly and function of synaptic junctions.  In addition we evaluating a variety of potential treatments for cognitive impairment in Down syndrome in part by assessing the impact specific drugs on cognitive function in mouse models of Down syndrome."},{"lastName":"Lee","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=29999&type=small&showNoImage","displayName":"SUNGJIN LEE","firstName":"SUNGJIN","href":"http://med.stanford.edu/profiles/SUNGJIN_Lee","researchInterest":""},{"lastName":"Smith","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4309&type=small&showNoImage","displayName":"Stephen J Smith","firstName":"Stephen","href":"http://med.stanford.edu/profiles/Stephen_Smith","researchInterest":"Research in the Smith Laboratory addresses basic mechanisms and and disorders of brain function.  Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex."},{"lastName":"Martinelli","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15033&type=small&showNoImage","displayName":"David Martinelli","firstName":"David","href":"http://med.stanford.edu/profiles/David_Martinelli","researchInterest":""},{"lastName":"Lee","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23467&type=small&showNoImage","displayName":"Soo Yeun Lee","firstName":"Soo Yeun","href":"http://med.stanford.edu/profiles/Soo Yeun_Lee","researchInterest":""},{"lastName":"Austin","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23769&type=small&showNoImage","displayName":"Dan Austin","firstName":"Daniel","href":"http://med.stanford.edu/profiles/Daniel_Austin","researchInterest":""},{"lastName":"Huguenard","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Molecular & Cellular Physiology"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4124&type=small&showNoImage","displayName":"John Huguenard","firstName":"John","href":"http://med.stanford.edu/profiles/John_Huguenard","researchInterest":"We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks."},{"lastName":"Luoma","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=24597&type=small&showNoImage","displayName":"Jessie Luoma","firstName":"Jessie","href":"http://med.stanford.edu/profiles/Jessie_Luoma","researchInterest":""},{"lastName":"Weiler","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"Ph.D., Dean's Office","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19763&type=small&showNoImage","displayName":"Nicholas Weiler","firstName":"Nicholas","href":"http://med.stanford.edu/profiles/Nicholas_Weiler","researchInterest":"I am interested in the structure of neocortex and the relation of circuit structure to neural activity and circuit function. My work in the Smith lab focuses on the development of array tomography methods to characterize and quantify populations of cortical synapses based on the diverse proteomic \"fingerprints\" of molecules characteristically expressed by different synapse types. My primary goal is to quantify the distribution of distinct synapse classes within columns of barrel cortex"},{"lastName":"Palmer","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Neurosurgery"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5930&type=small&showNoImage","displayName":"Theo Palmer","firstName":"Theo","href":"http://med.stanford.edu/profiles/Theo_Palmer","researchInterest":"For most areas of the mammalian brain, the production of new nerve cells or neurons is restricted to fetal development. However, there are exceptions to the rule. Some areas of the brain continue to make new neurons throughout life. This neurogenesis is mediated by neural stem cells and our research goals are to understand how stem cell activity and fate are controlled. Ultimately, we hope to harness the nascent potential of stem cells to treat neurological injury and disease."}]}