{"result":[{"lastName":"Longo","clinicalFocus":[{"focus":"Neurology"},{"focus":"Alzheimer's Disease"},{"focus":"Huntington Disease"}],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7249&type=small&showNoImage","displayName":"Frank M. Longo, M.D., Ph.D.","firstName":"Frank","href":"http://med.stanford.edu/profiles/Frank_Longo","researchInterest":"Clinical interests include Alzheimer\u0092s disease and Huntington\u0092s disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Kim","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=16537&type=small&showNoImage","displayName":"Taeho Kim","firstName":"Taeho","href":"http://med.stanford.edu/profiles/Taeho_Kim","researchInterest":""},{"lastName":"Lee","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=29999&type=small&showNoImage","displayName":"SUNGJIN LEE","firstName":"SUNGJIN","href":"http://med.stanford.edu/profiles/SUNGJIN_Lee","researchInterest":""},{"lastName":"Essock-Burns","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=34806&type=small&showNoImage","displayName":"Emma Essock-Burns","firstName":"Emma","href":"http://med.stanford.edu/profiles/Emma_Essock-Burns","researchInterest":""},{"lastName":"Stern","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences"}],"primaryAppointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=21153&type=small&showNoImage","displayName":"Christopher Stern","firstName":"Christopher","href":"http://med.stanford.edu/profiles/Christopher_Stern","researchInterest":""},{"lastName":"Tse","clinicalFocus":[],"appointments":[{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Stanford Cancer Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4421&type=small&showNoImage","displayName":"Victor Tse, MD PhD","firstName":"Victor","href":"http://med.stanford.edu/profiles/Victor_Tse","researchInterest":"My research focus is on tumor angiogenesis.  We are working on the contributions of progenitor cells in the formation of tumor vessels. We are particularly interested in a population of cells that are derived from putative \"hemangioblast\", and their role in vasculogenesis.  We sumrise that these cells have a close association with cancer stem cells, and are essential in promoting tumor expansion."},{"lastName":"Hestrin","clinicalFocus":[],"appointments":[{"appointment":"Professor,Comparative Medicine"}],"primaryAppointment":"Professor,Comparative Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4343&type=small&showNoImage","displayName":"Shaul Hestrin","firstName":"Shaul","href":"http://med.stanford.edu/profiles/Shaul_Hestrin","researchInterest":"The main interest of my lab is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. Our approach includes recordings from multiple cells, calcium imaging, two-photon imaging and viral-based optogenetic methods to activate  cortical neurons as well as cortical afferents."},{"lastName":"Alfa","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"},{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=17761&type=small&showNoImage","displayName":"Ronald Alfa","firstName":"Ronald","href":"http://med.stanford.edu/profiles/Ronald_Alfa","researchInterest":""},{"lastName":"Ge","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=21246&type=small&showNoImage","displayName":"Xuecai Ge","firstName":"Xuecai","href":"http://med.stanford.edu/profiles/Xuecai_Ge","researchInterest":"I am interested in how the Hedgehog signaling transduction is regulated, and how the mis-regulation of Hedgehog pathway leads to human diseases such as Medulloblastoma."},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Chen","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Psychiatry & Behavioral Science - Center for Interdisciplinary Brain Sciences Research"}],"primaryAppointment":"Associate Professor,Psychiatry & Behavioral Science - Center for Interdisciplinary Brain Sciences Research","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20934&type=small&showNoImage","displayName":"Lu Chen","firstName":"Lu","href":"http://med.stanford.edu/profiles/Lu_Chen","researchInterest":"What distinguishes us humans from other animals is our ability to undergo complex behavior. The synapses are the structural connection between neurons that mediates the communication between neurons, which underlies our various cognitive function. My research program aims to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation."},{"lastName":"Bergen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=29500&type=small&showNoImage","displayName":"Jamie Bergen","firstName":"Jamie","href":"http://med.stanford.edu/profiles/Jamie_Bergen","researchInterest":"The knottin family offers a diverse array of molecular scaffolds that can be engineered to guide imaging agents and drugs to sites of disease.  My research focuses on using knottins as a platform to design targeted drug therapies, and I am studying the delivery characteristics of engineered knottin-drug conjugates in relevant disease models."},{"lastName":"Giacomini","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"},{"appointment":"Ph.D., Dean's Office"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=17885&type=small&showNoImage","displayName":"Craig Giacomini","firstName":"Craig","href":"http://med.stanford.edu/profiles/Craig_Giacomini","researchInterest":""},{"lastName":"Koegel","clinicalFocus":[],"appointments":[{"appointment":"MD Student, School of Medicine"},{"appointment":"Medical School Tutor,Dean of Educational Resources - OAE Operations"},{"appointment":"Other Tech - Graduate,Dean of Educational Resources - OAE Operations"}],"primaryAppointment":"MD Student, School of Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=17752&type=small&showNoImage","displayName":"Ashley Koegel","firstName":"Ashley","href":"http://med.stanford.edu/profiles/Ashley_Koegel","researchInterest":""},{"lastName":"Fung","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=39130&type=small&showNoImage","displayName":"Lawrence Fung","firstName":"Lawrence","href":"http://med.stanford.edu/profiles/Lawrence_Fung","researchInterest":"Dr. Fung will employ state-of-the-art multimodal neuroimaging tools to study brain development in humans with fragile X syndrome (FraX) and autism spectrum disorder (ASD).  In parallel, he plans on conducting longitudinal multimodal neuroimaging studies in novel mouse models of fragile X syndrome. His overarching goal is to establish a framework for integrated interspecies translational research, which will accelerate the advancement of understanding of the pathophysiology of FraX and ASD and p"},{"lastName":"Graef","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","displayName":"Isabella Graef","firstName":"Isabella","href":"http://med.stanford.edu/profiles/Isabella_Graef","researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases."},{"lastName":"Valta","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Urology"}],"primaryAppointment":"Postdoctoral Research fellow, Urology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23892&type=small&showNoImage","displayName":"Maija Valta","firstName":"Maija","href":"http://med.stanford.edu/profiles/Maija_Valta","researchInterest":"Preclinical studies on bone metastasis of prostate cancer"}]}