{"result":[{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Yan","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Hematology"}],"primaryAppointment":"Instructor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13412&type=small&showNoImage","displayName":"Kelley Yan","firstName":"Kelley","href":"http://med.stanford.edu/profiles/Kelley_Yan","researchInterest":""},{"lastName":"Barron","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8312&type=small&showNoImage","displayName":"Annelise E. Barron","firstName":"Annelise","href":"http://med.stanford.edu/profiles/Annelise_Barron","researchInterest":"Biophysical mechanisms of host defense peptides and their mimics"},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Cartwright","clinicalFocus":[{"focus":"Gastroenterology"},{"focus":"Inflammatory Bowel Diseases"}],"appointments":[{"appointment":"Professor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4183&type=small&showNoImage","displayName":"Chris Cartwright, MD","firstName":"Christine","href":"http://med.stanford.edu/profiles/Christine_Cartwright","researchInterest":"Molecular mechanisms of intestinal cell growth control; function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells."},{"lastName":"Frimannsson","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=19052&type=small&showNoImage","displayName":"Daniel Omar Frimannsson","firstName":"Daniel","href":"http://med.stanford.edu/profiles/Daniel_Frimannsson","researchInterest":"My main research projects are focused on the investigation of the therapeutic effect of a novel prodrug-enzyme anticancer therapy and the development of a magnetic resonance imaging system that would enable the assessment of tumor metastasis in vivo, starting from a single cell. I have gained valuable experience in molecular cloning, protein manufacture and protein purification. My previous research included the pre-clinical testing of various different fluorescent reporters, anticancer agents "},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor (Research),Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4307&type=small&showNoImage","displayName":"Shoshana Levy","firstName":"Shoshana","href":"http://med.stanford.edu/profiles/Shoshana_Levy","researchInterest":"Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria."},{"lastName":"Rabkin","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Nephrology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6052&type=small&showNoImage","displayName":"Ralph Rabkin","firstName":"Ralph","href":"http://med.stanford.edu/profiles/Ralph_Rabkin","researchInterest":"Dr Rabkin is examining the mechanism of the acquired resistance to hormones that develops in kidney failure.In particular he is studying the impact of kidney failure on the action of growth hormone and the role of impaired signal transduction as a cause of growth hormone resistance. He is also engaged in the study of growth factors in diabetic kidney disease."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Sathiyamoorthy","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=21151&type=small&showNoImage","displayName":"Karthik Sathiyamoorthy","firstName":"Karthik","href":"http://med.stanford.edu/profiles/Karthik_Sathiyamoorthy","researchInterest":""},{"lastName":"Samos","clinicalFocus":[],"appointments":[{"appointment":"Science Writer/Editor,Neurosurgery"},{"appointment":"Information Editor,Neurosurgery"}],"primaryAppointment":"Science Writer/Editor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=28093&type=small&showNoImage","displayName":"Cynthia Samos","firstName":"Cynthia","href":"http://med.stanford.edu/profiles/Cynthia_Samos","researchInterest":""},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.  Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits."},{"lastName":"Leung","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Instructor,Dermatology"}],"primaryAppointment":"Instructor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23406&type=small&showNoImage","displayName":"Thomas Leung","firstName":"Thomas","href":"http://med.stanford.edu/profiles/Thomas_Leung","researchInterest":""},{"lastName":"Liu","clinicalFocus":[],"appointments":[{"appointment":"Engr Res Assoc,Genetics"}],"primaryAppointment":"Engr Res Assoc,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9027&type=small&showNoImage","displayName":"Tianyun Liu","firstName":"Tianyun","href":"http://med.stanford.edu/profiles/Tianyun_Liu","researchInterest":""},{"lastName":"McKay","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","displayName":"David B. McKay","firstName":"David","href":"http://med.stanford.edu/profiles/David_McKay","researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules."},{"lastName":"Gotlib","clinicalFocus":[{"focus":"Hematology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Hematology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4046&type=small&showNoImage","displayName":"Jason Gotlib","firstName":"Jason","href":"http://med.stanford.edu/profiles/Jason_Gotlib","researchInterest":"My research interests include phase I/II clinical trial evaluation of novel therapies for the following diseases:\r\n--Myelodysplastic syndromes (MDS)\r\n--Chronic myelogenous leukemia (CML)\r\n--Acute myelogenous leukemia (AML)\r\n--Myeloproliferative disorders (MPDs) including:\r\n    Hypereosinophilic syndrome\r\n    Systemic mastocytosis\r\n    BCR-ABL-negative MPDs"},{"lastName":"Kornberg","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4308&type=small&showNoImage","displayName":"Roger Kornberg","firstName":"Roger","href":"http://med.stanford.edu/profiles/Roger_Kornberg","researchInterest":"We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells"},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Vinayak","clinicalFocus":[{"focus":"Oncology"},{"focus":"Triple-negative breast cancer"},{"focus":"BRCA-associated breast cancer"},{"focus":"Locally advanced breast cancer"}],"appointments":[{"appointment":"Instructor,Medicine - Oncology"}],"primaryAppointment":"Instructor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10883&type=small&showNoImage","displayName":"Shaveta Vinayak","firstName":"Shaveta","href":"http://med.stanford.edu/profiles/Shaveta_Vinayak","researchInterest":"My research focuses on studying triple-negative breast cancer biology and identifying targeted treatment strategies.  I am interested in designing breast cancer clinical trials with strong translational endpoints so that we can identify a subset of patients who benefit the most from the targeted treatment.  Other interests include, prevention strategies for hormone receptor-negative breast cancer and survivorship issues."},{"lastName":"Teng","clinicalFocus":[{"focus":"Pediatric Dermatology"},{"focus":"Birthmarks"},{"focus":"Genetic Skin Disease"},{"focus":"Cell-based Therapy"},{"focus":"Cutaneous Surgery"},{"focus":"General skin conditions including atopic dermatitis, acne, viral exanthem, hair and nail disorders etc"}],"appointments":[{"appointment":"Clinical Associate Professor,Dermatology"},{"appointment":"Clinical Associate Professor,Pediatrics"}],"primaryAppointment":"Clinical Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=36149&type=small&showNoImage","displayName":"Joyce Teng","firstName":"Joyce","href":"http://med.stanford.edu/profiles/Joyce_Teng","researchInterest":""}]}