{"result":[{"lastName":"Chua","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Medicine - Endocrinology, Gerontology, & Metabolism"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Medicine - Endocrinology, Gerontology, & Metabolism","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6623&type=small&showNoImage","displayName":"Katrin Chua","firstName":"Katrin","href":"http://med.stanford.edu/profiles/Katrin_Chua","researchInterest":"Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals.  We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies.  In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress.  We have now begun to characterize the molecular mechanisms b"},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Boxer","clinicalFocus":[],"appointments":[{"appointment":"Ph.D., Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Ph.D., Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20204&type=small&showNoImage","displayName":"Lisa Boxer","firstName":"Lisa","href":"http://med.stanford.edu/profiles/Lisa_Boxer","researchInterest":""},{"lastName":"Tuteja","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15677&type=small&showNoImage","displayName":"Geetu Tuteja","firstName":"Geetu","href":"http://med.stanford.edu/profiles/Geetu_Tuteja","researchInterest":""},{"lastName":"Huang","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Neurology & Neurological Sciences"}],"primaryAppointment":"Associate Professor (Research),Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3930&type=small&showNoImage","displayName":"Ting-Ting Huang","firstName":"Ting-Ting","href":"http://med.stanford.edu/profiles/Ting-Ting_Huang","researchInterest":"We study the role of oxygen free radicals in oxidative tissue damage and degeneration. Our research tools include transgenic and knockout mice and tissue culture cells for in vitro gene expression."},{"lastName":"Rakhit","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10612&type=small&showNoImage","displayName":"Rishi Rakhit","firstName":"Rishi","href":"http://med.stanford.edu/profiles/Rishi_Rakhit","researchInterest":""},{"lastName":"Benayoun","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=21212&type=small&showNoImage","displayName":"Berenice Benayoun","firstName":"Berenice","href":"http://med.stanford.edu/profiles/Berenice_Benayoun","researchInterest":""},{"lastName":"Craig","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=35223&type=small&showNoImage","displayName":"Colleen Craig","firstName":"Colleen","href":"http://med.stanford.edu/profiles/Colleen_Craig","researchInterest":""},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Tasselli","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=17200&type=small&showNoImage","displayName":"Luisa Tasselli","firstName":"Luisa","href":"http://med.stanford.edu/profiles/Luisa_Tasselli","researchInterest":""},{"lastName":"Gitler","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Genetics"}],"primaryAppointment":"Associate Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=29296&type=small&showNoImage","displayName":"Aaron D. Gitler","firstName":"Aaron","href":"http://med.stanford.edu/profiles/Aaron_Gitler","researchInterest":"We investigate the mechanisms of human neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and ALS. We don't limit ourselves to one model system or experimental approach. We start with yeast, perform genetic and chemical screens, and then move to other model systems (e.g. mammalian tissue culture, mouse, fly) and even work with human patient samples (tissue sections, patient-derived cells, including iPS cells) and next generation sequencing approaches."},{"lastName":"Chung","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Obstetrics & Gynecology"}],"primaryAppointment":"Basic Life Science Research Associate,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10387&type=small&showNoImage","displayName":"Young Min Chung","firstName":"Young Min","href":"http://med.stanford.edu/profiles/Young Min_Chung","researchInterest":""},{"lastName":"McLaughlin","clinicalFocus":[{"focus":"Endocrinology / Diabetes"},{"focus":"Endocrinology and Metabolism"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Endocrinology, Gerontology, & Metabolism"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Endocrinology, Gerontology, & Metabolism","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6107&type=small&showNoImage","displayName":"Tracey McLaughlin","firstName":"Tracey","href":"http://med.stanford.edu/profiles/Tracey_McLaughlin","researchInterest":"Dr. McLaughlin conducts a number of clinical research studies related to obesity, insulin resistance, diabetes, and cardiovascular disease. Current studies include: 1) the impact of macronutrient composition on weight loss and cardiocascular risk (diabetic and nondiabetic patients); 2) comparison of weight loss and cardiovascular risk reduction in diabetic patients treated with different classes of antihyperglycemic drugs; 3) the role of the adipocyte in modulating insulin resistance"},{"lastName":"Valdmanis","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Pediatrics"}],"primaryAppointment":"Postdoctoral Research fellow, Pediatrics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=12455&type=small&showNoImage","displayName":"Paul Valdmanis","firstName":"Paul","href":"http://med.stanford.edu/profiles/Paul_Valdmanis","researchInterest":""},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Hori","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10323&type=small&showNoImage","displayName":"Sharon Hori","firstName":"Sharon","href":"http://med.stanford.edu/profiles/Sharon_Hori","researchInterest":""},{"lastName":"Couthouis","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=29305&type=small&showNoImage","displayName":"Julien COUTHOUIS","firstName":"Julien","href":"http://med.stanford.edu/profiles/Julien_Couthouis","researchInterest":""},{"lastName":"Maloney","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Neurology & Neurological Sciences"}],"primaryAppointment":"Basic Life Science Research Associate,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9199&type=small&showNoImage","displayName":"Michael Maloney","firstName":"Michael","href":"http://med.stanford.edu/profiles/Michael_Maloney","researchInterest":""},{"lastName":"Cosgrove","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10915&type=small&showNoImage","displayName":"Ben Cosgrove, Ph.D.","firstName":"Benjamin","href":"http://med.stanford.edu/profiles/Benjamin_Cosgrove","researchInterest":""},{"lastName":"Kraemer","clinicalFocus":[{"focus":"Endocrinology / Diabetes"},{"focus":"Lipid Metabolism Disorders"},{"focus":"Endocrinology and Metabolism"}],"appointments":[{"appointment":"Professor,Medicine - Endocrinology, Gerontology, & Metabolism"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Endocrinology, Gerontology, & Metabolism","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4133&type=small&showNoImage","displayName":"Fredric Kraemer","firstName":"Fredric","href":"http://med.stanford.edu/profiles/Fredric_Kraemer","researchInterest":"Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology."},{"lastName":"Graef","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","displayName":"Isabella Graef","firstName":"Isabella","href":"http://med.stanford.edu/profiles/Isabella_Graef","researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases."},{"lastName":"Giffard","clinicalFocus":[],"appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4657&type=small&showNoImage","displayName":"Rona Giffard","firstName":"Rona","href":"http://med.stanford.edu/profiles/Rona_Giffard","researchInterest":"Astrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis for brain cell injury in stroke.  We study gene therapy with heat shock and other protective proteins, the effects of specific microRNAs, changes in mitochondrial function, oxidative stress and inflammation during ischemia. We also model cell death pathways and the effects of Hsp70."},{"lastName":"Ruiz-Lozano","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Pediatrics - Cardiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Associate Professor (Research),Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=18359&type=small&showNoImage","displayName":"Pilar Ruiz-Lozano, Ph.D.","firstName":"Pilar","href":"http://med.stanford.edu/profiles/Pilar_Ruiz-Lozano","researchInterest":"Cardiac development and repair"}]}