Sayanti Bhattacharya
Publication Details
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Immunopharmacological basis of the healing of indomethacin-induced gastric mucosal damage in rats by the constituents of Phyllanthus emblica
CURRENT SCIENCE. 2007; (1): 47-53Studies were designed to establish the individual active compound present in the ethanolic extract of the plant Phyllanthus emblica (EOE), contributing to the healing of indomethacin-induced gastric lesions in rats. The ulcerated rats received EOE, or purified fraction of EOE (which is pure gallic acid, GA). EOE and GA significantly reduced the serum levels of IL-1b and TNF-a in mice injected with endotoxin, lipopolysaccharide. The experimental groups treated with GA had significantly reduced ulcer index, serum levels of pro-inflammatory cytokines, nitric oxide synthase and interleukin-8 receptor in the gastric epithelial cells, and increased hepatic arginase activity compared to the experimental control group. The studies suggest that GA-induced modification of the inflammatory response contributed significantly in the ulcer-healing process, suggesting the role of GA, a major chemical constituent of P. emblica, in the healing of ulcers induced by indomethacin.
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