Brian Hoffman
Publication Details
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Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness.
Clin Pharmacol Ther. 1993; (4): 463-8
To determine whether the considerable interindividual variability in nitroglycerin-induced venodilation in humans is related to the polymorphic expression of the mu class of glutathione S-transferase (GST mu). Recently vascular glutathione S-transferase (EC 2.5.1.18) of the mu-class (GST mu), a polymorphic group of enzymes present in only about 60% of the population, have been identified and shown in vitro to possess high metabolic activity toward nitroglycerin. Their clinical relevance is unknown.
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