Brian Hoffman
Publication Details
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Nicotine impairs endothelium-dependent dilatation in human veins in vivo.
Clin Pharmacol Ther. 2000; (4): 391-7
Cigarette smoking is associated with impaired endothelium-dependent dilatation in human veins and arteries. An in vivo study in animals suggests that nicotine may contribute to this abnormality. We tested the hypothesis that local administration of nicotine at a dose reproducing the plasma concentration observed during smoking would impair endothelium-dependent vasodilatation in human veins in vivo.
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