Marion S. Buckwalter
Publication Details
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TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.
J Neuroinflammation. 2010: 62
TGFβ is both neuroprotective and a key immune system modulator and is likely to be an important target for future stroke therapy. The precise function of increased TGF-β1 after stroke is unknown and its pleiotropic nature means that it may convey a neuroprotective signal, orchestrate glial scarring or function as an important immune system regulator. We therefore investigated the time course and cell-specificity of TGFβ signaling after stroke, and whether its signaling pattern is altered by gender and aging.
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