Martin S. Angst
Publication Details
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Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision.
Mol Pain. 2008: 7
The chronic use of opioids prior to surgery leads to lowered pain thresholds and exaggerated pain levels after these procedures. Several mechanisms have been proposed to explain this heightened sensitivity commonly termed opioid-induced hyperalgesia (OIH). Most of these proposed mechanisms involve plastic events in the central or peripheral nervous systems. Alterations in the abundance of peripheral mediators of nociception have not previously been explored.
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