Jonathan Pollack
Publication Details
-
Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host.
Clin Cancer Res. 2010; (14): 3684-95
The most common preclinical models of pancreatic adenocarcinoma utilize human cells or tissues that are xenografted into immunodeficient hosts. Several immunocompetent, genetically engineered mouse models of pancreatic cancer exist; however, tumor latency and disease progression in these models are highly variable. We sought to develop an immunocompetent, orthotopic mouse model of pancreatic cancer with rapid and predictable growth kinetics.
Help