Mamoun Alhamadsheh
Publication Details
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Design, total synthesis, and evaluation of novel open-chain epothilone analogues.
Org Lett. 2006; (4): 685-8[structure: see text] The design, total synthesis, and biological evaluation of two open-chain analogues of epothilone incorporating the critical C1-C8 fragment and the aromatic side chain held together by a small molecular scaffold have been achieved. Biological evaluation revealed that further restraint between the flexible C1-C8 region and the molecular scaffold may be necessary for potent inhibition of cell proliferation.
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