Community Academic Profiles–

Paul Yock, MD

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Publication Details

  • Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.

    Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D. Circulation. 2003; 108 (19): 2304-7

    Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that delta-protein kinase C (deltaPKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for deltaPKC during reperfusion only, using an in vivo porcine model of AMI.

    PubMedID: 14597593

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