Anthony G. Doufas, M.D., Ph.D.
Publication Details
-
Dexmedetomidine and meperidine additively reduce the shivering threshold in humans.
Stroke. 2003; (5): 1218-23
Hypothermia might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia provokes vigorous shivering. Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with minimal sedation. We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression.
Help