Anthony G. Doufas, M.D., Ph.D.
Publication Details
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Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output.
Br J Anaesth. 2006; (6): 708-14
Tissue oxygenation is the primary determinant of wound infection risk. Mild hypercapnia markedly improves cutaneous, subcutaneous (s.c.), and muscular tissue oxygenation in volunteers and patients. However, relative contributions of increased cardiac output and peripheral vasodilation to this response remains unknown. We thus tested the hypothesis that increased cardiac output is the dominant mechanism.
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