Community Academic Profiles–

Ejung Moon

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Publication Details

  • Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

    Kasper AC, Moon EJ, Hu X, Park Y, Wooten CM, Kim H, Yang W, Dewhirst MW, Hong J. Bioorg Med Chem Lett. 2009; 19 (14): 3783-6

    We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

    PubMedID: 19423348

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