Eric Kool
Publication Details
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Sandwich probes: two simultaneous reactions for templated nucleic acid detection.
Chem Commun (Camb). 2010; (43): 8154-6
Fluorescence-quenched nucleic acid probes with reactive moieties at both the 5' and 3' ends are synthesized and tested for reaction with two adjacent nucleophile-containing DNAs. These probes improve signal to background over singly reactive probes and can discriminate single nucleotide polymorphisms in the target DNA or RNA.
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