Douglas L. Brutlag
Publication Details
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GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning.
Nucleic Acids Res. 1982; (1): 323-40
We have built a knowledge-based genetic engineering simulation system-- GENESIS-- capable of representing both domain-specific and general knowledge. Information is stored within a hierarchically-organized framework composed of structures called units. A series of sophisticated editors enables no-computer specialist molecular geneticists to construct a knowledge base through direct interaction with the computer. Three types of knowledge specific to the domain of molecular genetics, MAPS, sequences and RULES are discussed in detail with examples.
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