Robert Sapolsky
Publication Details
-
Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release.
Stroke. 2004; (2): 572-7
We showed previously that Bcl-2 overexpression with the use of herpes simplex viral (HSV) vectors improved striatal neuron survival when delivered 1.5 hours after stroke but not when delivered 5 hours after stroke onset. Here we determine whether hypothermia prolongs the therapeutic window for gene therapy.
Help