John Cooke, MD, PhD
Publication Details
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Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Circulation. 2001; (21): 2569-75
Hyperhomocysteinemia is a putative risk factor for cardiovascular disease, which also impairs endothelium-dependent vasodilatation. A number of other risk factors for cardiovascular disease may exert their adverse vascular effects in part by elevating plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase. Accordingly, we determined if homocysteine could increase ADMA levels.
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