Matthew P. Scott
Publication Details
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Tail wags dog: primary cilia and tumorigenesis.
Cancer Cell. 2009; (4): 276-7
Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine (Han et al., 2009; Wong et al., 2009) show that mutating cilia can increase or reduce the rates of tumorigenesis depending on how the Hh pathway is disrupted.
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