Pankaj Jay Pasricha
Publication Details
-
Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed intestinal transit in burned rats.
Am J Surg. 2007; (4): 530-7
Burn injury has been shown to impair intestinal transit. p38 mitogen-activated protein kinase (MAPK) has been shown to be involved in the production of proinflammatory mediators such as interleukin (IL)-1beta, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). The aims of this study were to investigate the effects of SB203580, a specific p38 MAPK inhibitor, on intestinal transit and to elucidate its possible mechanism.
Help