Pankaj Jay Pasricha
Publication Details
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P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity.
Gut. 2008; (9): 1230-7
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and the underlying molecular mechanisms of visceral hyperalgesia remain elusive. Recent studies of somatic and other visceral pain models suggest a role for purinergic signalling mediated by the P2X receptor (P2XR) family.
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